1-Methylpyrrolidin-3-ol
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- CAS-Nr.
- 13220-33-2
- Bezeichnung:
- 1-Methylpyrrolidin-3-ol
- Englisch Name:
- 1-Methyl-3-pyrrolidinol
- Synonyma:
- 1-METHYL-PYRROLIDIN-3-OL;3-HYDROXY-1-METHYLPYRROLIDINE;NSC 89279;3-Hydroxy-1-methyL;N-Methyl-3-hydroxy-;1-Methyl-3-pyrrolidi;N-methyl-3-pyrrolitol;N-Methyl-3-pyrrolidinol;1-METHYL-3-PYRROLIDINOL;N-Methyl-pyrrolidin-3-ol
- CBNumber:
- CB9296691
- Summenformel:
- C5H11NO
- Molgewicht:
- 101.15
- MOL-Datei:
- 13220-33-2.mol
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1-Methylpyrrolidin-3-ol Eigenschaften
- Siedepunkt:
- 50-52 °C1 mm Hg(lit.)
- Dichte
- 0.921 g/mL at 25 °C(lit.)
- Brechungsindex
- n20/D 1.464(lit.)
- Flammpunkt:
- 159 °F
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Oil
- pka
- 14.95±0.20(Predicted)
- Farbe
- Colourless
- InChI
- InChI=1S/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3
- InChIKey
- FLVFPAIGVBQGET-UHFFFAOYSA-N
- SMILES
- N1(C)CCC(O)C1
- CAS Datenbank
- 13220-33-2(CAS DataBase Reference)
- NIST chemische Informationen
- 1-Methyl-3-pyrrolidinol(13220-33-2)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H227 |
Combustible liquid |
Flammable liquids |
Category 4 |
Warnung |
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P210, P280, P370+P378, P403+P235,P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P405 |
Unter Verschluss aufbewahren. |
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1-Methylpyrrolidin-3-ol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Clear colorless to pale yellow liquid
Verwenden
1-Methyl-3-pyrrolidinol (cas# 13220-33-2) is a compound useful in organic synthesis.
Synthese
A 500 mL four-necked flask was charged with a 40 wt% aqueous solution of monomethylamine and cooled to 10 ° C in an ice-water bath. Then, while stirring, 1,4-dichloro-2-butanol was added dropwise, and the temperature was controlled at 15 ° C. Then pour the system into an Autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1MPa, while heated to 120 ℃, the reaction was stirred for about 10h. After the reaction was over and cooled to room temperature, the material was discharged, batch-wise added sodium hydroxide was released, and a large amount of methylamine gas, controlling the temperature below 50 ℃, precipitated a lot of white solid, stirred for 1h; filtration, the filtrate layered, the upper organic phase Ethanol And anhydrous magnesium sulfate, stirring 2 ~ 3h; and then filtered, the filtrate was concentrated in vacuo to give a yellow transparent oily liquid, and then vacuum distillation to give colorless and t1-Methyl-3-pyrrolidinol, Yield 64.8%, purity 99.3%.
1-Methylpyrrolidin-3-ol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Methylpyrrolidin-3-ol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 342)Lieferanten
13220-33-2(1-Methylpyrrolidin-3-ol)Verwandte Suche:
- N-Methyl-pyrrolidin-3-ol
- 1-Methyl-3-hydroxypyrrolidine
- NSC 89279
- N-Methyl-pyrrolidinyl alcohol
- 1-Methyl-3-pyrrolidinol,97%
- 1-Methyl-3-pyrrolidi
- 3-Hydroxy-1-methylpyrroli...
- N-Methyl-3-hydroxy-
- 1- Methyl-3-pyrrolidonealcohol
- 3-Hydroxy-1-Methylpyrrolidine, 95+%
- 3-Hydroxy-1-methylpyrrolidine,97%
- 1-Methyl-3-pyrrolidinol 95%
- 1-methyl-3-hydroxy-terthydropyrrolo
- 3-Pyrrolidinol, 1-methyl-
- N-Methyl-3-pyrrolidinol
- N-METHYL-3-HYDROXY PYRROLIDINE
- N-Methyl-3-Pyrrolidionol
- 3-Hydroxy-1-methylpyrrplidine
- 1-METHYL-3-PYRROLIDINOL
- 3-HYDROXY-N-METHYLPYRROLIDINE
- 3-Hydroxy-1-methyL
- 3-HYDROXY-1-METHYLPYRROLIDINE
- 1-METHYL-PYRROLIDIN-3-OL
- N-methyl-3-pyrrolitol
- 3-hydroxy-1-methyltetrahydropyrrole
- 3-Hydroxy-N -methyl pyrrolidine(Racemate)
- Molnupiravir Impurity 32
- Glycopyrrolate Impurity(1 methyl-3-pyrrolidinol)
- Glycopyrrolate Impurity 50
- 13220-33-2
- 13320-33-2
- Pyrrolidines
- Heterocyclic Building Blocks
- Building Blocks
- Heterocyclic Compounds
- Heterocycles
- Building Blocks
- Heterocyclic Building Blocks
- Pyrrolidines
