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2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on

Hyperoside Struktur
482-36-0
CAS-Nr.
482-36-0
Bezeichnung:
2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on
Englisch Name:
Hyperoside
Synonyma:
HYPERIN;QUERCETIN-3-O-GALACTOSIDE;quercetin 3-O-β-D-galactopyranoside;QUERCETIN-3-GALACTOSIDE;QUERCETIN-3-D-GALACTOSIDE;HYPEROSID;actoside;hyperasid;HYPEROSIDE;hyperozide
CBNumber:
CB9240043
Summenformel:
C21H20O12
Molgewicht:
464.38
MOL-Datei:
482-36-0.mol

2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Eigenschaften

Schmelzpunkt:
225-226°C
Siedepunkt:
872.6±65.0 °C(Predicted)
Dichte
1.87±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand
Solid
pka
6.17±0.40(Predicted)
Farbe
Light Yellow to Yellow
BRN 
5784795
LogP
-0.111 (est)
CAS Datenbank
482-36-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-40
S-S?tze: 22-45-36-24/25
WGK Germany  3
RTECS-Nr. DJ3009200
10-23
HS Code  29389090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Hypericin, which is widely found in various plants, such as Hypericum, Rosaceae, Campanulaceae, Labiatae, Rhododendron, Asteraceae Kwai, Garciniaceae, Leguminosae, Euonymus, and other fruits and whole grass, is a flavonoid compound.

Chemische Eigenschaften

Yellow Solid

Physikalische Eigenschaften

Appearance: yellowish needlelike crystals. Melting point: 227–229 °C. Specific optical rotation: ?83° (c = 0.2, pyridine). Solubility: soluble in ethanol, methanol, acetone, and pyridine. Hydrochloric acid–magnesium powder reaction yielded formation of cherry red; ferric chloride reaction was green; α-naphthol reaction was positive.

History

In 1960, Nair et al. isolated hyperin from redosier dogwood, in which its content is 0.075%. Flavonoids in the treatment of cardiovascular and cerebrovascular diseases play a pivotal role, among which rutin is a typical representative. Isoquetin mainly presents in the leaves of kumquat flowers and the oleander plant kenaf, and it can also be obtained by chemical synthesis. It shows an anti-inflammatory effect through the capillary permeability test and other animal experiments. It also has a toxic effect on the larvae of Chilohabala larvae. It is one of the active ingredients of Hypericum japonicum, which is used in the treatment of hepatitis because of its inhibition of the activities of hepatic enzyme.

Verwenden

Hyperoside is used as a primary reference standard in the analysis of herbal medicinal products. It may be used as a calibration standard in method validation of polyphenols from leaf extracts using HPLC method.

Definition

ChEBI: A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.

Indications

This product is available in the British Pharmacopoeia (2017) and the European Pharmacopoeia (9.0th ed.).
Monomeric compounds are currently used clinically. In clinical practice, hypericin is the main active ingredient of proprietary Chinese medicines, such as Acanthopanax capsules, of which Acanthopanax stem and leaf extract are the raw materials for the preparation. Xin’an capsules, prepared with hawthorn leaf extract, are rich in flavonoids, in which hyperoside, a kind of flavonoid, is one of the main components. Qi yue lipid-lowering tablets are prepared from the effective parts of Chinese medicinal herbs such as hawthorn (Nucleation) and Astragalus membranaceus. Flavonoid is one of the main active ingredients in hawthorn, in which hyperoside content is higher. Xinxuening tablets, containing ursolic acid, vitexin rhamnoside, hyperoside, citric acid, and others, is a preparation made from hawthorn and pueraria and other traditional Chinese medicines, in which hawthorn enhances the actions of the medicine. Clinical indications of Xinxuening tablets are coronary heart disease, angina pectoris, chest tightness, palpitations, high blood pressure, arrhythmia, hyperlipidemia, and mental depression.

Allgemeine Beschreibung

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 362)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
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025-85710122 17714198479
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18017610038
zheyansh@163.com CHINA 3619 58
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+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8816 58

482-36-0(2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on)Verwandte Suche:


  • hyperasid
  • hyperozide
  • HYPEROSIDE
  • QUERCETIN-3B-D-GALACTOSIDE
  • HYPEROSIDE hplc
  • HYPEROSIDE 98.0% BY HPLC
  • QUERCETIN-3-O-BETA-GALACTOSIDE
  • HYPEROSIDE WITH HPLC
  • 2-(3,4-dihydroxyphenyl)-3-(beta-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(.beta.-D-galactopyranosyloxy)-5,7-dihydroxy-
  • HYPEROSIDE(P)
  • 3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-
  • Hyperin, Hyperoside
  • Hyperoside,Hyperin,Quercetin 3-D-galactoside
  • 2-(3,4-dihydroxyphenyl)-3-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-chromene-4,5,7-triol
  • 3,3′,4′,5,7-Pentahydroxyflavone 3-D-galactoside, Hyperin, Hyperoside
  • quercetin 3-O-beta-D-galactopyranoside
  • Hyperoside (50 mg)
  • 2-(3,4-Dihydroxyphenyl)-3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • Hyperoside, Hyperin
  • Hyperin,Quercetin3-galactoside,Quercetin-3-O-galactoside
  • 4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-3-(beta-d-galactopyranosyloxy)-5
  • Hyperoside, froM AbelMoschus Manihot (L.) Medic.
  • Hyperoside Quercetin 3-D-galactoside
  • Hyperoside [Quercetin 3-galactoside]
  • 3,3′,4′,5,7-Pentahydroxyflavone 3-D-galactoside
  • Quercetin 3-D-gaL
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
  • QUERCETIN-3-O-GALACTO
  • Hyperoside, 98%, from Abelmoschus manihot (L.) Medic.
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1-benzopyran-4-one
  • Hyperoside 482-36-0
  • actoside
  • Quercetin 3-D-g
  • HYPERIN
  • QUERCETIN-3-D-GALACTOSIDE
  • QUERCETIN-3-O-GALACTOSIDE
  • QUERCETIN-3-GALACTOSIDE
  • quercetin 3-O-β-D-galactopyranoside
  • HYPEROSID
  • quercetin3-O-β-D-galactopyranoside
  • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
  • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-
  • Quercetin 3-β-galactoside
  • Hypericum Perforatum Extract/ Hyperoside
  • Hyperoside(AS)
  • Hyperoside-RM
  • 482-36-0
  • Natural Dyes
  • Biochemicals and Reagents
  • BioChemical
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Intermediates & Fine Chemicals
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