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DMT-dC(bz) Phosphoramidite

DMT-dC(bz) Phosphoramidite Struktur
102212-98-6
CAS-Nr.
102212-98-6
Englisch Name:
DMT-dC(bz) Phosphoramidite
Synonyma:
DMT-dC(Bz)-CE;DMT-dC(bz) amidite;DNAC-PHOSPHORAMIDITE;Bz-dC Phosphoramidite;DMT-dC(Bz)-CE Amidites;DMT-dC-CEPhosphoramidite;2'-dC(Bz)Phosphoramidite;dC(Bz) CE Phosphoramidite;DMT-dC(bz) Phosphoramidite;dC (N-Bz) Phosphoramidite
CBNumber:
CB9226852
Summenformel:
C46H52N5O8P
Molgewicht:
833.91
MOL-Datei:
102212-98-6.mol

DMT-dC(bz) Phosphoramidite Eigenschaften

Schmelzpunkt:
>84°C (dec.)
Dichte
1.23 at 20℃
Dampfdruck
0-0Pa at 20-50℃
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
Chloroform, DMSO, Methanol (Slightly)
Aggregatzustand
powder or granules
pka
8.65±0.20(Predicted)
Farbe
white to off-white
InChIKey
PGTNFMKLGRFZDX-SALLYJDFSA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(=O)C3=CC=CC=C3)=NC2=O)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,45,r|
LogP
6.5 at 20℃
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 24/25
WGK Germany  3
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

DMT-dC(bz) Phosphoramidite Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

DMT-dC(bz) Phosphoramidite, also known as 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite or (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (IUPAC Name), is a novel nucleoside amidite analog, which can be subjected in the synthesis of DNA.
DMT-dC(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:
Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides.

Verwenden

5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Synthese

Synthesis_102212-98-6
These Examples illustrate the phosphitylation of several protected nucleoside reagents with 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite in the presence of several activators according to the present invention. Eleven phosphitylation reactions (1-11) comprising reacting a protected nucleoside reagent with 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite in the presence of an acid-base activator according to the present invention were conducted, and the product yields of each calculated, as described in the General Procedure, below. The various combinations of protected nucleoside, activator base, activator acid, solvent, and yield for each of the 11 reactions are listed in Table 1. General Procedure: The activator base (1.1 to 1.2 equivalents) is added to the solvent and 0.95 to 1.1 equivalents of activator acid is subsequently added thereto at ambient temperature to form the activator solution. About 1 equivalent of the protected nucleoside is dissolved in about 10 equivalents of the solvent in a separate vessel and about 3 equivalents of the solvent is then distilled off under reduced pressure. About 1 to 1.2 equivalents of 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite is added to the nucleoside mixture at ambient temperature, and the activator solution prepared previously is then added to the nucleoside mixture at ambient temperature with vigorous stirring. After 12 hours, the reaction mixture is diluted with toluene and washed with water. The organic layer is separated, dried over sodium sulfate if necessary, and concentrated under reduced pressure. The yield of the desired amidite is then calculated using HPLC techniques, that is, the resulting product mixture is run through an HPLC column using an appropriate eluent, and the area under the HPLC peaks used to determine the %yield of product in the mixture.

DMT-dC(bz) Phosphoramidite Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DMT-dC(bz) Phosphoramidite Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 186)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zhejiang Hengkang Pharmaceutical Co., Ltd.
+86-576-83372028 +86-18868723926
bd1@hengkangpharm.cn China 119 58
Chemtour Biotech Co., Ltd
+8617327281506
market@chemtour.com China 1460 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830
figo.gao@foxmail.com China 8497 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Yunbio Tech Co.,Ltd.
+86-010-60605551 +86-18046518538
yunbiochem@126.com China 321 58
Nanjing Baifuli Technology Co., Ltd.
+86-15335185688
sales@unisyn.cn CHINA 332 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58

102212-98-6()Verwandte Suche:


  • REF DUPL: DMT-dC(bz) Phosphoramidite
  • Bz-dC Phosphoramidite
  • N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite ,98%
  • N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite
  • 2'-DEOXYCYTIDINE PHOSPHORAMIDITE
  • DNAC-PHOSPHORAMIDITE
  • dC (N-Bz) Phosphoramidite
  • N-blocked-5'-O-DMT 3'-CED deoxycytidine phosphoramidite
  • (2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
  • DMT-dC(bz) Phosphoramidite
  • DMT-DC(BZ) AMIDITE 2G AB 12 PACK
  • 3'-O-P-5'-O-DMT-N-BZ-2'-DEOXY-CYTIDINE [DC(BZ) PHOSPHORAMIDITE]
  • 5'-Dimethoxytrityl-N-benzoyl-3'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • DMT-dC-CEPhosphoramidite
  • N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoraMidite
  • DMT-dC(bz) Amidite 1g, 89, 12 Pack
  • DMT-dC(bz) Amidite 20g, 6 Pack
  • DMT-DC(BZ) AMIDITE 5G 6 PACK
  • DMT-dC(bz) Amidite 4g, 60ml vial, 12 Pac
  • DMT-dC(bz) Amidite 2g, 60ml vial, 12 Pac
  • DMT-DC(BZ) AMIDITE 10G 6 PACK
  • DMT-DC(BZ) AMIDITE 10G SINGLE
  • DMT-DC(BZ) AMIDITE 1G AB 12 PACK
  • DMT-dC(bz) Amidite 1g, 60ml vial, 12 Pac
  • DMT-dC(bz) Amidite 7.65g, 6 Pack
  • DMT-DC(BZ) AMIDITE 5G SINGLE
  • DMT-DC(BZ) AMIDITE 2G 89 12 PACK
  • N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
  • N6-Benzoyl-5'-O-DMT-2'-deoxycytidine-3'-CE Phosphoramidite
  • DMT-dC(Bz)-CE Phosphoramidite
  • N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-cyanoethyl Phosphoramidite
  • DMT-dC(bz) amidite
  • n-benzoyl-5'-o-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • N4-BENZOYL-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-2'-DEOXYCYTIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
  • 5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite
  • N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite, 99%, R and S mixture
  • dC(bz) β-Cyanoethylphosphoramidite (mixture of isomers)isomers)
  • Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • N4-Benzoyl-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite
  • DMT-dC(bz) Phosphoramidite USP/EP/BP
  • 5'-DMT-Bz-dC phosphoramidite
  • 5'-Dimethoxytrityl-N-benzoyl-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • N4-Benzoyl-5'-O-(4,4'-DMT)-2’-dC-3'-CE Phosphoramidite
  • 5-O-(4,4-Dimethoxytrityl)-N4-benzoyl-2-deoxycytidine-3-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite
  • DMT-dC(Bz)-CE
  • N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
  • dC(Bz) CE Phosphoramidite
  • 5'-O-DMT-N4-Benzoyl-2'-Deoxy Cytidine-3’-Cyanoethyl Phosphoramidite
  • deoxy N-Bz Cytidine Amidite
  • DMT-dC(Bz)-CE Amidites
  • N -Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-cyanoethyl-N,N-diisopropylphosphoramidite(DMT-dC(bz)phosphoramidite)(Ac-dC phosphoramidite)
  • DMTr-dC(Bz)-3'-CE-Phosphoramidite
  • Bz dC Beta-Cyanoethyl Phosphoramidite (500 mg) (5'-O-Dimethoxytrityl-N4-benzoyl-2'-deoxycytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite)
  • N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]benzamide
  • 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite
  • 5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite
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