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Sapropterin Hydrochloride

Sapropterin Hydrochloride Struktur
69056-38-8
CAS-Nr.
69056-38-8
Englisch Name:
Sapropterin Hydrochloride
Synonyma:
Sapropterin Dihydrochloride;Sapropterin HCl;Sapropterin DiHCl;Kuvan;Tetrahydro-L-Biopterin (hydrochloride);(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE;6R-BH4;sun0588;Biopten;THB, 2HCL
CBNumber:
CB9206285
Summenformel:
C9H17Cl2N5O3
Molgewicht:
314.17
MOL-Datei:
69056-38-8.mol

Sapropterin Hydrochloride Eigenschaften

Schmelzpunkt:
245-246° (dec)
alpha 
D25 -6.81° (c = 0.665 in 0.1 M HCl)
storage temp. 
-20°C
L?slichkeit
water, oxygen free: soluble19.60 - 20.40mg/mL, clear to slightly hazy, colorless to faintly yellow
Aggregatzustand
White to off-white powder.
Farbe
White to off-white
Stabilit?t:
Hygroscopic
CAS Datenbank
69056-38-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
WGK Germany  3
RTECS-Nr. UO3516500
Toxizit?t LD50 oral in rat: 1gm/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Sapropterin Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

Beschreibung

Sapropterin hydrochloride is a monoamine biosynthesis enhancer introduced for the treatment of hyperphenylalaninemia.Animal studies indicate that sapropterin hydrochloride increases brain levels of serotonin and enhances the release of acetylcholine from nerve terminals. The compound is also being investigated as a potential cognitive enhancer.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

A natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthase. An essential cofactor for the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Increasing

Definition

ChEBI: The dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydrox lase, tryptophan hydroxylase, and nitric oxide synthetase.

Allgemeine Beschreibung

Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.

l?uterung methode

Recrystallisation of BH4.2HCl from HCl enriches BH4 in the natural 6R isomer. Dissolve the salt (~6g) in conc HCl (15mL) under gentle warming, then add EtOH (30mL) dropwise, chill and collect the colourless needles (67%, up to 99% if the mother liquors are concentrated), and dry it in vacuo immediately over P2O5 and KOH. It is stable indefinitely at -20o in a dry atmosphere. Better store it in sealed ampoules under dry N2. It can be recrystallised from 6N aqueous HCl. It has UV max (in 2N HCl) at 264nm ( 16,770; pH 3.5 phosphate buffer) 265nm ( 13,900); (in pH 7.6) at 297nm ( 9,500) and 260nm sh ( 4,690). It has been separated from the 6S-isomer by HPLC on a Partisil-10SCX column using 30mM ammonium phosphate buffer (pH 3.0) containing 3mM NaHSO3 (2mL/minute flow rate; 275nm detector) with retention times of 5.87minutes (6R) and 8.45minutes (6S). It is stable in acidic solutions and can be stored for extended periods at -20o in 0.04M HCl. Above pH 7 the neutral species are obtained, and these are readily oxidised by the oxygen in the solvent to the quinonoid species, and then further oxidation and degradation occurs at room temperature. These changes are slower at 0o. The sulfate salt can be obtained by recrystallisation from 2M H2SO4 and is less soluble in water than the hydrochloride salt. The 6R-2,5,1',2'-tetraacetylbiopterin derivative has m 292o(dec) after recrystallisation from MeOH (100 parts) and [] 20 -144o (c 0.5, CHCl3), [] 589 +12.8o (c 0.39, Me2SO). [NMR, UV: Matsuura et al. Heterocycles 23 3115 1985, Viscontini et al. Helv Chim Acta 62 2577 1979, Armarego et al. Aust J Chem 37 355 1984, Beilstein 26 III/IV 4032.]

Sapropterin Hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sapropterin Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 200)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12829 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9220 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8816 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58

69056-38-8()Verwandte Suche:


  • (6r-(6r*(1r*,2s*)))-chlorid
  • (6r)-tetrahydrobiopterinhydrochloride
  • 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinondihydro
  • 2-AMINO-6R-(1R,2S-DIHYDROXYPROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE, DIHYDROCHLORIDE
  • BH4 DIHYDROCHLORIDE
  • TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE
  • sapropterinhydrochloride
  • sun0588
  • 6R-BH4
  • (6R)-BH4 2HCL
  • [6R-[6R*(1R*,2S*)]]-2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE DIHYDROCHLORIDE
  • (6R)-5,6,7,8-TETRAHYDRO-BIOPTERIN DIHYDROCHLORIDE
  • 6-BETA-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
  • THB, 2HCL
  • (6R)-5,6,7,8-Tetrahydro-biopterin,2HCl,6R-BH4
  • (6R)-Tetrahydro-L-biopterindihydrochloride
  • (6R)-5,6,7,8-Tetrahydro-biopterin, Dihydrochloride, 6R-BH4
  • Tetrahydro-L-biopterin2HCl
  • 4(3H)-Pteridinone,2-aMino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, hydrochloride(1:2), (6R)-
  • (6b)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
  • 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, dihydrochloride, [6R-[6R*(1R*,2S*)]]-
  • 4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, dihydrochloride, (6R)- (9CI)
  • Biopten
  • BioMarin T 1401
  • Shiratori SN 0588
  • Sapropterin(Tetrahydrobiopterin)
  • (R)-2-AMino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride
  • Tetrahydrobiopterin (THB) dihydrochloride, >=99%
  • Tetrahydrobiopterin (THB) dihydrochloride
  • [6R-[6R*(1R*,2S*)]]-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone . 2HCl
  • Tetrahydrobiopterin, Dihydrochloride
  • (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochlori
  • 6R-BH4 dihydrochloride
  • Tetrahydrobiopterin Dihydrochloride, R-THBP Dihydrochloride
  • Sapropterin dihydrochloride, >98%
  • Tetrahydrobiopterin/BH4
  • Tetrahydro -L- biopterin
  • Sapropterin DiHCl (Dehydro Sepiapterin DiHCl)
  • (6R)-5,6,7,8-Tetrahydro-l-biopterin diHCl
  • (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
  • Tetrahydro-L-Biopterin (dihydrochloride)s
  • (6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
  • Kuvan
  • Sapropterin Dihydrochloride
  • Tetrahydro-L-Biopterin (hydrochloride)
  • Sapropterin DiHCl
  • Sapropterin HCl
  • (6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride)
  • (R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one hydrochloride
  • (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one
  • 69056-38-8
  • C9H17Cl2N5O3
  • C9H15N5O32HCl
  • C9H15N5O32ClH
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