Arformoterol tartrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sepracor’s Brovana®, a nebulized long acting bronchodilator, was launched in the U.S. in April 2007. The β2- adrenoceptor agonist is indicated for the twice-daily, longtermmaintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema. It is the first long-acting nebulized bronchodilator approved by the FDA for this indication.

Verwenden

Anti-asthmatic and bronchodilator.

Synthese

There are several reports on the synthesis of arformoterol. A large-scale synthesis of enantio/diastereomerically pure (R,R)-formoterol is cited here. Bromoalcohol 22 was synthesized in 84% yield with 94% e.e. through the catalytic enantioselective reduction of bromo ketone 21. The nitro functional group in 22 was reduced in quantitative yield by hydrogena-tion in the presence of Adams catalyst and the resulting aniline was isolated by filtration of the catalyst and removal of the solvent. In order to avoid auto-oxidation, the aniline was treated with a mixture of formic acid and acetic anhydride immediately after the removal of the platinum catalyst. Upon concentrating the reaction mixture, bromohydrin 23 crystallized and could be isolated in 75% yield with 98.6% e.e. It was further enriched to >99.5% e.e. by a single re-crystallization from ethylacetate. Next, a mixture of bromohydrin 23 and amine salt (R)-26-(S)-mandelic acid was treated with K2CO3 resulting in generation of the corresponding epoxide of 23 and liberation of the free base of (R)-26. After an aqueous work up to remove salts and mandelic acid, the reaction mixture was heated to 120??C to affect epoxide opening with the amine of 26. Removal of the benzyl protecting groups of the resulting crude product via catalytic hydrogenation followed by salt formation with tartaric acid afforded arformoterol tartrate (III) in 70% yield upon crystallization.

Arformoterol tartrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Arformoterol tartrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29815	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32002	58

200815-49-2()Verwandte Suche:

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• Arformoterol tartrate
• Afromoterol tartrate
• (R,R)-Formoterol tartrate
• N-(2-Hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide (2R,3R)-2,3-dihydroxybutanedioate (1:1)
• (-)-ForMoterol-d6 L-Tartrate , ArforMoterol-d6 L-Tartrate
• (R,R)-(-)-ForMoterol-d6 Tartrate
• (R,R)-ForMoterol-L-(+)-Tartrate API
• (R,R)-ForMoterol-L-(+)-Tartrate
• R,R-Form L-tartrate
• N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide L-tartrate
• (2R,3R)-2,3-dihydroxybutanedioic acid,N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide
• R-[4-(benzyloxy)-3-(formanmino)phenyl]oxirane
• Arformoterol tartrate Solution in Methanol, 100μg/mL
• (R,R)-(-)-Formoterol tartrate salt
• 200-589-5
• Aphmote tartrate
• (R,R)-Formoterol tartrate (Arformoterol tartrate)
• Formoterol Impurity 23 Tartrate
• Aforterol tartrate
• Formoterol Impurity 28 Tartrate
• (R,R)-Formoterol L-Tartrate (Arformoterol L-Tartrate)
• 200815-49-2
• 00815-49-2
• C19H24N2O4C4H6O6
• C23H30N2O10
• APIs