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Zolpidem tartrate

Zolpidem tartrate Struktur
99294-93-6
CAS-Nr.
99294-93-6
Englisch Name:
Zolpidem tartrate
Synonyma:
ambien;Myslee;Stilnox;ZOLPIDEM TARTRATE;L-(+)-Hemitartrate;ZOLPIDEM HEMITARTRATE;ZolMitriptan Tartrate;Zolpidem Tartrate Tablet;ZOLPIDEM TARTRATE EP C IV;AMBIEN(Zolpidem Tartrate)
CBNumber:
CB7451799
Summenformel:
C23H27N3O7
Molgewicht:
457.48
MOL-Datei:
99294-93-6.mol

Zolpidem tartrate Eigenschaften

Schmelzpunkt:
196 °C
storage temp. 
2-8°C
L?slichkeit
Slightly soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
Aggregatzustand
Solid
Farbe
White to Off-White
BCS Class
1
CAS Datenbank
99294-93-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,T,F
R-S?tze: 36/37/38-39/23/24/25-23/24/25-11
S-S?tze: 26-36-45-36/37-16-7
HS Code  2933996500
Giftige Stoffe Daten 99294-93-6(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 2
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Zolpidem tartrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White or almost white, hygroscopic, crystalline powder.

Verwenden

Sedativehypnotic.

Definition

ChEBI: The hemitartrate salt of zolpidem.

Pharmakokinetik

Zolpidem exhibits a high selectivity for the α1 subunit. Its good bioavailability of 72% and rapid onset of action of approximately 1.4 hours following oral absorption can be attributed to its weak base (pKa = 6.2) and high lipophilicity (mlog P = 3.85). Its pharmacokinetic profile is characterized by rapid absorption from the gastrointestinal tract and a short elimination half-life because of rapid oxidative metabolism to inactive carboxylic acid metabolites. Zolpidem undergoes CYP3A4 (major), CYP2DG, and CYP2D6 hydroxylation of the aryl methyl groups, followed by further oxidation by aldehyde dehydrogenase to the ionic carboxylic acids, which are readily eliminated in the urine.
Zolpidem demonstrates linear (dose-proportional) kinetics in the dose range of 5 to 20 mg. Although protein binding was 90%, no drug accumulation was observed following nightly dosing with 20-mg zolpidem tartrate tablets for 2 weeks. Food can prolong the time to peak concentration from 1.4 to 2.2 hours without affecting the half-life. These results suggest that for faster sleep onset, zolpidem should not be administered with or immediately after a meal. In the elderly, the dose should be 5 mg, because the elimination half-life is increased by 50% (from ~2 to ~3 hours). No accumulation was observed in elderly subjects following nightly oral dosing of 10 mg for 1 week. In patients with hepatic insufficiency, the plasma concentration doubled with an increase in the elimination half-life from approximately 2 to approximately 10 hours (range, 4–25 hours). Therefore, dosing should be modified in patients with hepatic insufficiency. No dosage adjustment should be necessary in patients with compromised renal function. Zolpidem is not hemodialyzable, but it does cross the placenta and into breast milk. Because of its longer elimination half-life (when compared to zaleplon), it may be preferred when sleep maintenance is a primary concern.

Zolpidem tartrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

99294-93-6()Verwandte Suche:


  • N,N-Dimethyl-2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetamide 2,3-dihydroxysuccinate
  • L-(+)-Hemitartrate
  • ,r*))-2,3-dihydroxybutanedioate(2:1)
  • 2-a)pyridine-3-acetamide,n,n,6-trimethyl-2-(4-methylphenyl)-imidazo((r-(r*
  • ambien
  • n,n,6-trimethyl-2-p-tolyl-imidazo(1,2-a)pyridine-3-acetamide l-(+)-tartrate (2:1)
  • ZOLPIDEM HEMITARTRATE
  • ZOLPIDEM TARTRATE
  • Zolpidem tartrate solution
  • Zolpidem Tartrate Tablet
  • ZOLPIDEM TARTRATE EP C IV
  • N,,6-Trimethyl-2-P-Tolyl-Imidazo(1,2-A)Pyridine-3-AcetamideL-(+)-Tartrate
  • Imidazo1,2-apyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)
  • Myslee
  • Zolpidem Tartrate CIV (200 mg) (COLD SHIPMENT REQUIRED)
  • ZolMitriptan Tartrate
  • NYVVVBWEVRSKIU-UHFFFAOYSA-N
  • AMBIEN(Zolpidem Tartrate)
  • N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)-3-imidazo[1,2-a]pyridinyl]acetamide
  • Zolpidem L-(+)-Hemitartrate zolpidem tartrate
  • N,N-dimethyl-2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetamide hemi((2R,3R)-2,3-dihydroxysuccinate)
  • Zolpidem tartrate USP/EP/BP
  • Stilnox
  • ZolpidemTartarateQ: What is ZolpidemTartarate Q: What is the CAS Number of ZolpidemTartarate Q: What is the storage condition of ZolpidemTartarate Q: What are the applications of ZolpidemTartarate
  • Zolpidem Tartrate(Z2500000)
  • Zolpidem Tartrate CIV (COLD SHIPMENT REQUIRED) (1724907)
  • Zolpidem L-(+)-hemitartrate
  • 99294-93-6
  • 2C19H21N3OC4H6O6
  • C19H21N3OC4H6O6
  • C19H21N3O12C4H6O6
  • C4H6O62C19H21N3O
  • C21H24N3O4
  • Hypnotic
  • Zolpidem
  • Active Pharmaceutical Ingredients
  • API
  • 11
  • 99294-93-6
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