gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1)
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gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Eigenschaften
- Schmelzpunkt:
- 130-135 °C (lit.)
- alpha
- -1~+1°(D/20℃)(c=5,DMF)
- Dichte
- 1.1984 (rough estimate)
- Brechungsindex
- 1.6800 (estimate)
- Flammpunkt:
- 9℃
- storage temp.
- 2-8°C
- L?slichkeit
- Freely soluble in water, soluble in ethanol (96 per cent)
- Aggregatzustand
- Solid
- Farbe
- White to Almost white
- Geruch (Odor)
- odorless
- PH
- 4.0~5.5 (10g/l, 25℃)
- Wasserl?slichkeit
- 1-5 g/100 mL at 21 ºC
- Merck
- 14,2180
- BCS Class
- 3/1
- InChIKey
- DBAKFASWICGISY-BTJKTKAUSA-N
- LogP
- 3.389 (est)
- EPA chemische Informationen
- Chlorpheniramine maleate (113-92-8)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T,F | ||
---|---|---|---|
R-S?tze: | 25-39/23/24/25-23/24/25-11 | ||
S-S?tze: | 36/37/39-45-36/37-16 | ||
RIDADR | UN 2811 6.1/PG 3 | ||
WGK Germany | 3 | ||
RTECS-Nr. | US6504000 | ||
TSCA | Yes | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29333990 | ||
Toxizit?t | LD50 orally in mice: 162 mg/kg (Smith) |
Bildanzeige (GHS) |
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gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.S-S?tze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.Chemische Eigenschaften
White SolidVerwenden
(±)-Chlorpheniramine maleate salt has been used:- as H1 receptor antagonist to determine the receptor function
- to block the effect of compound 48/80 on plasma IGF-I
- as a standard for fast sensing and determination by sequential injector coupled with potentiometer
Allgemeine Beschreibung
Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.Air & Water Reaktionen
Water soluble.Reaktivit?t anzeigen
A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.Brandgefahr
Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.Sicherheitsprofil
Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 768)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085; +8615531157085 |
abby@chuanghaibio.com | China | 8808 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5979 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 +86-18829239519 |
sales06@tgybio.com | China | 898 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5862 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 |
sales@sdperfect.com | China | 294 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 |
nickzhang@hangyubiotech.com | China | 10983 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20232 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
admin@oudaxin.com | China | 114 | 58 |
airuikechemical co., ltd. | +86-18353166132 +86-18353166132 |
sales02@airuikechemical.com | China | 983 | 58 |
113-92-8(gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1))Verwandte Suche:
N,N-Dimethyl-1,3-diaminopropan
Dipikrylamin
Maleins?ureanhydrid
Schwefelwasserstoff
Wasserstoff
Chlordimethylphenylsilan
[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]ammoniumhydrogenmaleat
Dinatriumfumarat
POLY(1-BUTENE)
[1-Ethyl-1-phenyl-2-(3,4,5-trimethoxybenzoyloxy)ethyl]dimethylammoniumhydrogenmaleat
1-(2-Oxo-2-pyrrolidin-1-ylethyl)-4-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperazinmonomaleat
Rosiglitazone maleate
Isopropylamin
2,6-Dimethylpyridin
Maleins?ure
Propane
CHLORPHENIRAMINE
Amphetamin
- 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate
- 1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
- 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
- Chlorophenamine
- Chlorprophenpyridamine maleate
- Cloropiril
- Histaspan
- Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, maleate (1:1) (8CI)
- (+-)-Chloropheniramine
- 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
- 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
- 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-
- 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
- 4-Chloropheniramine
- 9: PN: US20030109453 SEQID: 8 claimed sequence
- Allergican
- Chlorophenylpyridamine
- Chloroprophenpyridamine
- Chlorprophenpyridamine
- dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propane
- Haynon
- RS-Chlorpheniramine
- γ-(4-Chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
- 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin maleate
- 1-(p-chlorophenyl)-1-(2-pyridyl)-3-n,n-dimethylpropylamine
- 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin
- 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
- 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine
- gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin
- CHLOROPHENIRAMINE BASE
- Chlorpheniramine (base and/or unspecified salts)
- 1-(N,N-Dimethylamino)-3-(p-chlorophenyl)-3-(alpha-pyridyl)propane maleate
- 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
- Chlorphenamine hydrogen maleate
- 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat
- 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
- allerclor
- allergin
- alunex
- carbinoxamidemaleate
- chlormene
- chloroprophenpyridaminemaleate
- chlor-tripolon
- c-meton
- dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridinemaleate
- gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioa
- gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate
- histadurdura-tabs
- ibioton
- lorphen
- m.p.chlorcapst.d.
- nci-c55265
- neorestamin
- piriex
- polaronil
- pyridamal-100
- synistamin
- LABOTEST-BB LT00134667