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Iguratimod

Iguratimod Struktur
123663-49-0
CAS-Nr.
123663-49-0
Englisch Name:
Iguratimod
Synonyma:
N-(7-(MethylsulfonaMido)-4-oxo-6-phenoxy-4H-chroMen-3-yl)forMaMide;T 614;ALM-3;CS-1961;IGURATIMOD;Iguratimod >iguratimod( R&D);IguratiMod (T 614);Iguratimod USP/EP/BP;Iguratimod (intermediates I4,I6)
CBNumber:
CB91011295
Summenformel:
C17H14N2O6S
Molgewicht:
374.37
MOL-Datei:
123663-49-0.mol

Iguratimod Eigenschaften

Schmelzpunkt:
238.0 to 242.0 °C
Siedepunkt:
580.6±60.0 °C(Predicted)
Dichte
1.52±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
L?slichkeit
DMSO (Slightly)
Aggregatzustand
Solid
pka
5.58±0.20(Predicted)
Farbe
White to Off-White
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2935.90.9500
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Iguratimod Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In August 2011, China’s State FDA approved Simcere Pharmaceutical Group’s new drug application for iguratimod (T-614), a disease modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Preclinical in vivo studies indicated that iguratimod was effective in an established adjuvant-induced arthritis model (ED40=3.6 mg/kg) in rats and also efficacious in a type II collagen-induced arthritis model in DBA/1J mice at 30 mg and 100 mg/kg.

Verwenden

Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.

Clinical Use

Iguratimod, which was discovered by Toyama Pharmaceuticals and jointly co-developed with Eisai in Japan, was approved by the PMDA (Pharmaceuticals and Medical Devices Agency) of Japan on June 29, 2012 for the treatment of rheumatoid arthritis. This drug was also independently developed by Simcere Pharmaceutical Group and is marked as Iremod® in China. The drug exhibited inhibitory effects on granuloma inflammation, and was shown to be efficacious for the prevention of joint destruction in adjuvant arthritis.

Iguratimod Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Iguratimod Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 300)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
Hebei Ganmiao New material Technology Co., LTD
+86-17332992504 +86-17332992504
sales8@hbganmiao.com China 300 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338
stella@zetchem.com China 2136 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58

123663-49-0()Verwandte Suche:


  • iguratimod( R&D)
  • T 614
  • N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide
  • 3-(Formylamino)-7-(methylsulfonylamino)-6-phenoxy-4H-1-benzopyran-4-one
  • N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide
  • IguratiMod (T 614)
  • IGURATIMOD
  • CS-1961
  • N-[7-(methanesulfonamido)-4-oxo-6-phenoxy-1-benzopyran-3-yl]formamide
  • Iguratimod >
  • Methanesulfonamide, N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-
  • N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide
  • N-[7-(Methanesulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl]formamide
  • Iguratimod USP/EP/BP
  • IguratimodQ: What is Iguratimod Q: What is the CAS Number of Iguratimod Q: What is the storage condition of Iguratimod Q: What are the applications of Iguratimod
  • N-(7-(MethylsulfonaMido)-4-oxo-6-phenoxy-4H-chroMen-3-yl)forMaMide
  • Iguratimod (intermediates I4,I6)
  • N-(7-(Methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide (Iguratimod Impurity)
  • 3-Formylamino-7-methylsulfonamido-6-phenoxy-4h-1-benzopyran-4-one
  • ALM-3
  • 123663-49-0
  • Pharmaceutical intermediate
  • Pharmaceuticals
  • API
  • 123663-49-0
  • 1
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