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PF-06873600

PF-06873600 Struktur
2185857-97-8
CAS-Nr.
2185857-97-8
Englisch Name:
PF-06873600
Synonyma:
Ebvaciclib;PF-06873600;PF06873600,PF 06873600;Ebvaciclib (PF-06873600);6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）
CBNumber:
CB84918288
Summenformel:
C20H27F2N5O4S
Molgewicht:
471.52
MOL-Datei:
2185857-97-8.mol

PF-06873600 Eigenschaften

Siedepunkt:
634.0±65.0 °C(Predicted)
Dichte
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO:15.0(Max Conc. mg/mL);31.81(Max Conc. mM)
Aggregatzustand
A solid
pka
14.69±0.40(Predicted)
InChIKey
QIEKHLDZKRQLLN-FOIQADDNSA-N
SMILES
C1(NC2CCN(S(C)(=O)=O)CC2)=NC=C2C=C(C(F)F)C(=O)N([C@@H]3CCC[C@]3(O)C)C2=N1

Sicherheit

PF-06873600 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively. It also blocks the phosphorylation of retinoblastoma protein (RB1) and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.

PF-06873600 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PF-06873600 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 79)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10311 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
NINGBOBENKANGJS PHARMTECHCO., LTD 		+8615990591583 15990591583
 CHINA 2029 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Jiangsu Nata Opto-electronic Material Co.,Ltd. 		+86-0512-62520998 +86-15030927757
 gaoym@natachem.com China 229 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658
 sales1@artkmedchem.com China 39004 58
  • PF-06873600
  • Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-
  • Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）
  • 6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
  • Ebvaciclib (PF-06873600)
  • Ebvaciclib
  • PF06873600,PF 06873600
  • 2185857-97-8
  • C20H27F2N5O4S
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