PF-06873600
- CAS No.
- 2185857-97-8
- Chemical Name:
- PF-06873600
- Synonyms
- Ebvaciclib;PF-06873600;PF06873600,PF 06873600;Ebvaciclib (PF-06873600);PF-06873600, 10 mM in DMSO;6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）
- CBNumber:
- CB84918288
- Molecular Formula:
- C20H27F2N5O4S
- Molecular Weight:
- 471.52
- MDL Number:
- MFCD31807623
- MOL File:
- 2185857-97-8.mol
| Boiling point | 634.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:15.0(Max Conc. mg/mL);31.81(Max Conc. mM) |
| form | A solid |
| pka | 14.69±0.40(Predicted) |
| InChIKey | QIEKHLDZKRQLLN-FOIQADDNSA-N |
| SMILES | C1(NC2CCN(S(C)(=O)=O)CC2)=NC=C2C=C(C(F)F)C(=O)N([C@@H]3CCC[C@]3(O)C)C2=N1 |
| FDA UNII | 3B512HJD65 |
PF-06873600 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0078633 | PF-06873600 99.98% | 2185857-97-8 | 5mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0078633 | PF-06873600 99.98% | 2185857-97-8 | 10mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0078633 | PF-06873600 99.98% | 2185857-97-8 | 25mg | $1750 | 2021-12-16 | Buy |
| ChemScene | CS-0078633 | PF-06873600 99.98% | 2185857-97-8 | 50mg | $2750 | 2021-12-16 | Buy |
| ChemScene | CS-0078633 | PF-06873600 99.98% | 2185857-97-8 | 100mg | $3950 | 2021-12-16 | Buy |
PF-06873600 Chemical Properties,Uses,Production
Description
PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively. It also blocks the phosphorylation of retinoblastoma protein (RB1) and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.
Mechanism of action
PF-06873600 is taken as a tablet by mouth. PF-06873600 is a cancer growth blocker targeting specific proteins called Cyclin-Dependent Kinase 2, 4, and 6 (CDK2/4/6). It works by stopping or preventing the action of these proteins, which stimulate cancer cells to grow and divide. PF-06873600 selectively targets, binds to, and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are essential regulators of cell cycle progression and cellular proliferation are frequently overexpressed in tumour cells.
PF-06873600 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06873600 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10417 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| NINGBOBENKANGJS PHARMTECHCO., LTD | +8615990591583 15990591583 | CHINA | 2029 | 58 | |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Jiangsu Nata Opto-electronic Material Co.,Ltd. | +86-0512-62520998 +86-15030927757 | gaoym@natachem.com | China | 229 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39004 | 58 |
View Lastest Price from PF-06873600 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | PF-06873600
2185857-97-8
|
US $52.00-198.00 / mg | 99.36% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-05-26 | PF-06873600
2185857-97-8
|
US $0.00-0.00 / mg | 100mg | 95% | 1kg | Jiangsu Nata Opto-electronic Material Co.,Ltd. |
-
- PF-06873600
2185857-97-8
- US $52.00-198.00 / mg
- 99.36%
- TargetMol Chemicals Inc.
-
- PF-06873600
2185857-97-8
- US $0.00-0.00 / mg
- 95%
- Jiangsu Nata Opto-electronic Material Co.,Ltd.