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Glimepiride

Glimepiride Struktur
93479-97-1
CAS-Nr.
93479-97-1
Englisch Name:
Glimepiride
Synonyma:
AMARYL;Glimpiride;GliMipride;N-(4-ethyl-3-methyl-5-oxo-2H-pyrrol-1-yl)-3-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]propanamide;amary;hoe490;Grimepride;glimepirid;GliMperide;Glenn urea
CBNumber:
CB8318552
Summenformel:
C24H34N4O5S
Molgewicht:
490.62
MOL-Datei:
93479-97-1.mol

Glimepiride Eigenschaften

Schmelzpunkt:
212.2-214.5 °C
Dichte
1.29±0.1 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO: >10 mg/mL
pka
5.10±0.10(Predicted)
Aggregatzustand
solid
Farbe
white
Merck 
14,4440
BCS Class
2
CAS Datenbank
93479-97-1(CAS DataBase Reference)
EPA chemische Informationen
1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans- 4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo- (93479-97-1)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 21-36/38-46-62-63
S-S?tze: 25-26-36/37-53
WGK Germany  3
RTECS-Nr. UX9363950
HS Code  2935904000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Glimepiride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R21:Gesundheitssch?dlich bei Berührung mit der Haut.
R36/38:Reizt die Augen und die Haut.
R46:Kann vererbbare Sch?den verursachen.
R62:Kann m?glicherweise die Fortpflanzungsf?higkeit beeintr?chtigen.
R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.

S-S?tze Betriebsanweisung:

S25:Berührung mit den Augen vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.

Beschreibung

Glimepiride, the first of a new generation of sulfonylurea drugs, was introduced in Sweden in 1995 as a first-line therapy to lower blood glucose in patients with type II diabetes. Sulfonylureas exert their hypoglycemic function primarily by direct stimulation of insulin secretion in glucose-insensitive pancreatic β-cells and GLUT translocation in insulin-resistant fat and muscle cells. Once-daily, orally administered glimepiride in diabetes patients showed a more rapid and longer lasting glucose-lowering effect than the commonly used agent glibenclamide. Glimepiride can be used either as a monotherapy or in combination with insulin.

Chemische Eigenschaften

White Cyrstalline Solid

Verwenden

Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Allgemeine Beschreibung

Glimepiride is 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]-carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide; thiscompound can also be named as the urea—see precedingdiscussion (Amaryl, generic). Combinations are availablewith rosiglitazone in the United States (Avandaryl tablets;mg glimepiride/mg rosiglitazone as maleate salt: 1/4,2/4, 4/4, 2/8, 4/8); and with pioglitazone (Duetact tablets;mg glimepiride/ mg pioglitazone as hydrochloride salt:2/30, 4/30).

Biologische Aktivit?t

Potent K ATP channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K ATP channels with an IC 50 of 6.8 nM.

Glimepiride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Glimepiride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 654)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 3009 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55

93479-97-1()Verwandte Suche:


  • 3-ETHYL-2,5-DIHYDRO-4-METHYL-N-[2-[4-[[[[(TRANS-4-METHYLCYCLOHEXYL)AMINO]CARBONYL]AMINO]SULFONYL]PHENYL]ETHYL]-2-OXO-1H-PYRROLE-1-CARBOXAMIDE
  • 3-ETHYL-2,5-DIHYDRO-4-METHYL-N-[2-[4-[[[[(TRANS-4-METHYLCYCLOHEXYL)AMINO]CARBONYL]AMINO]SULFONYL]PHENYL]ETHYL]-2-OXO-1H-PYRROLE-1-CARBOXYAMIDE
  • Gliclazide(diamicron)
  • CLIMEPIRIDE
  • trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(4-methyleyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide
  • 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide
  • 1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-2-4-(trans-4-methylcyclohexyl)aminocarbonylaminosulfonylphenylethyl-2-oxo-
  • 1H-Pyrrole-1-carboxamide, 2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino) carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans
  • 1-[[4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-ylcarbonyl)amino]ethyl]phenyl]sulfonyl]-3-(4α-methylcyclohexan-1β-yl)urea
  • 1-[[p-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-ylcarbonylamino)ethyl]phenyl]sulfonyl]-3-[(1β)-4α-methylcyclohexyl]urea
  • Grimepride
  • GliMepiride(AMaryl)
  • 1h-pyrrole-1-carboxamide,2,5-dihydro-3-ethyl-4-methyl-n-(2-(4-(((((4-methylcyc
  • glimepirid
  • hoe490
  • trans-lohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo
  • GLIMEPIRIDE
  • amary
  • Glimepiride (200 mg)
  • 3-ethyl-4-Methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-Methylcyclohexyl]carbaMoyl}aMino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxaMide
  • GliMperide
  • trans-3-Ethyl-2,5-dihydro-4-Methyl-N-[2-[4-[[[[trans-4-Methylcyclohexyl)aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyaMide
  • GliMepiride COS
  • 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea
  • 1-(4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenylsulfonyl)-3-((1r,4r)-4-methylcyclohexyl)urea
  • Glimepiride Solution, 100ppm
  • Glimepiride 93479-97-1
  • Customization Available
  • High Quality With Factory Price
  • Professional Manufacturer
  • Glimepiride RS
  • Glimepiride CRS
  • Glimepiride>
  • Glimepiride for system suitability CRS
  • Glimepiride solution in Acetonitrile/Methanol, 1000ug/ml
  • Glenn urea
  • Glimepiride USP/EP/BP
  • Glimepiride (Glimperide
  • GlimepirideQ: What is Glimepiride Q: What is the CAS Number of Glimepiride Q: What is the storage condition of Glimepiride Q: What are the applications of Glimepiride
  • Glimepiride (Y0000515)
  • Glimepiride for system suitability (Y0000516)
  • Glimepiride (1292303)
  • 3-Ethyl-4-methyl-N-(4-(N-((rel-(1r,4r)-4-methylcyclohexyl)carbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
  • AMARYL
  • Glimpiride
  • GliMipride
  • N-(4-ethyl-3-methyl-5-oxo-2H-pyrrol-1-yl)-3-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]propanamide
  • 7,8-Dihydroxyflavone 38183-03-8
  • Glimepiride IP/EP/USP
  • Glimepiride 1-[[p-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea
  • Glimepiride Reference Standard
  • GLIMEPIRIDE IP
  • Glimepiride in methanol
  • 3-Ethyl-4-methyl-N-(4-(N-(((1r,4r)-4-methylcyclohexyl)carbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide (Glimepiride Impurity)
  • 93479-97-1
  • 93479-91-1
  • C24H30D4N4O5S
  • C24H34N4O5S
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