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Liothyronin

3,3',5-Triiodo-L-thyronine Struktur
6893-02-3
CAS-Nr.
6893-02-3
Bezeichnung:
Liothyronin
Englisch Name:
3,3',5-Triiodo-L-thyronine
Synonyma:
Liothyronine;cytomel;L-T3;O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine;l-triiodothyronine;triiodo-l-thyronine;Thyro3;l-liothyr;NSC 80203;tresitope
CBNumber:
CB8221269
Summenformel:
C15H12I3NO4
Molgewicht:
650.97
MOL-Datei:
6893-02-3.mol

Liothyronin Eigenschaften

Schmelzpunkt:
234-238 °C(lit.)
alpha 
23 º (c=2 in ethanol)
Siedepunkt:
232°C (rough estimate)
Dichte
2.2155 (estimate)
Flammpunkt:
9°C
storage temp. 
-20°C
L?slichkeit
DMSO (Slightly), Methanol (Very Slightly)
Aggregatzustand
powder
pka
pKa 8.5 (Uncertain);8.4 (Uncertain);8.45 (Uncertain)
Farbe
Off-white to pale yellow
Optische Aktivit?t
[α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
Wasserl?slichkeit
Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.
Sensitive 
Light Sensitive
Merck 
14,5510
BRN 
2710227
Stabilit?t:
Light Sensitive
CAS Datenbank
6893-02-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi,T,F
R-S?tze: 20/21/22-36/37/38-39/23/24/25-23/24/25-11
S-S?tze: 36-26-36/37/39-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS-Nr. AY6750000
8
HS Code  29225090
Giftige Stoffe Daten 6893-02-3(Hazardous Substances Data)
Toxizit?t LDLo oral in rat: 7500mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Liothyronin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Crystalline T3 (liothyronine sodium, Cytomel) has a rapid onset and short duration of action. It is the therapy of choice when it is desirable to have rapid onset or cessation of activity, such as in patients with heart disease.

Chemische Eigenschaften

Off-White Solid

Verwenden

T3 or 3,3',5-Triiodo-L-thyronine is a thyroid hormone involved with many physiological processes in the human body including growth and development, metabolism, body temperature and heart rate. Free and total T3 serum levels are measured by LC-MS/MS for determination of hyperthyroidism caused by excess T3. This Certified Spiking Solution? is suitable for use as a starting material in preparation of linearity standards, calibrators, and controls for thyroid hormone testing methods by LC-MS/MS.

Definition

ChEBI: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxi e in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Application

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.
3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Biologische Aktivit?t

3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

l?uterung methode

Likely impurities are as in thyroxine. Purify it by dissolving in dilute NH3 at ~20o, then crystallise it by addition of dilute acetic acid to pH 6. Alternatively 35g are purified by dissolving it in a mixture of EtOH (250mL) and 2N NaOH (100mL), then hot 2N HCl is added to the boiling solution until the pH is 4-5. After cooling for a few hours, the solid is filtered off and dried in a vacuum [m 233-235o(dec)]. [Chambers et al. J Chem Soc 2433 1949, Beilstein 14 III 1566, 14 IV 2373.]

Liothyronin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Liothyronin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 281)Lieferanten
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Suzhou Ryan Pharmachem Technology Co.,Ltd.
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Wuhan Fortuna Chemical Co., Ltd
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+86-0371-86658258 +8613203830695
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6893-02-3(Liothyronin)Verwandte Suche:


  • L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- (9CI)
  • NSC 80203
  • Thyronine, 3,3',5-triiodo-, L- (6CI)
  • IODOTHYRONINE
  • 3,3,5-TRIIODO-L -THYRONINE 95-98% FREE ACID CRYSTALLINE
  • 3,3μ,5 Triiodothyronine (T3)
  • 3,3μ,5-Triiodo-L-thyronine, Liothyronine, T3, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
  • Liothyronine, T3, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
  • Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L
  • l-liothyr
  • 3,3′,5-Triiodo-L-thyronine,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3
  • Liothyronine (250 mg)
  • Liothyronine (250 mg)M0D3380.993mg/mg(dr)
  • 3,5,3′-Triiodo-L-thyronine 3,5,3′-Triiodo-L-thyronine
  • 3,3',5-triiodo-L-thyronine 2
  • (S)-2-Amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid
  • L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo
  • Three triiodothyronine
  • 3,3′,5-Triiodo-L-thyronine, >=99%
  • 3,3',5-Triiodo-L-thyronine
  • 3,3,5-Triiodo-L-thyronine≥ 99% (HPLC: Anhydrous basis)
  • 3,3’,5-triiodothyronine
  • 3,5,3’-triiodothyronine
  • 3’,5-triiodo-l-thyronin
  • 4-(3-iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine
  • 5-diiodophenyl)-3-(4-(4-hydroxy-3-iodophenoxy)-l-alanin
  • l-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine
  • l-liothyronine
  • lyothyronine
  • o-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosin
  • t3(aminoacid)
  • t3(hormone)
  • tresitope
  • 3,3',5'-TRIIODO-L-THYRONINE
  • L-3,3,5-Triiodothyronine, Free Acid
  • 2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid
  • Alanine, 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, L- (8CI)
  • triothyrone
  • β-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine
  • L-3,3',5'-TRIIODOTHYRONINE
  • LiothyronineSodiumB.P.
  • 5-Triiodothyronine
  • 3,3′,5-Triiodo-L-thyronine (T3) solution
  • Levothyroxine Impurity 1(Levothyroxine EP Impurity A)
  • Triiodo-thyroninum (3,3,5-triiodo-L-thyrnine)
  • T3) (Solution)
  • Triiodothyronine (T3) (solution)
  • 3,3',5-Triiodo-L-thyronine >
  • O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine USP/EP/BP
  • order fat burners cytomel raw T3 powder
  • l-liothyronine(T3)
  • Thyro3
  • 3,3,5 - TRIIODO - L - FREEACIDCRYSTALLINE THYRONINE95-98%
  • L-3-iodothyronine
  • Thyronine, 3, 3 ', 5 - triiodo -, L - (ci)
  • 3,3,5-TRIIODOChemicalbook-L-THYRONINE95-98%FREEACIDCRYSTALLINE
  • TIANFU CHEM 6893-02-3 O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
  • 3,3,5-Triiodo-L-Thyronine extrapure, 95%
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