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Duract was launched in the US as a potent, orally-active, long lasting peripheral
analgesic with antiinflammatory properties. It is structurally similar to ketoprofen and
diclofenac and can be prepared in three steps from 2-amino-4’-bromophenone using
Gassman’s oxindole synthesis. Duract’s biological effects are a result of its ability to
reduce prostaglandin production through inhibition of cyclooxygenase. As a 4-bromo
derivative of Amfenac, this modification increased the duration of analgesic activity
and antiinflammatory potency. It was also free of any CNS, cardiovascular or
autonomic effects. In comparison, 5 mg of Duract was equipotent to 650 mg of ASA
and 25 mg was slightly more potent than 400 mg of Ibuprofen.
Chemische Eigenschaften
Yellow Solid
Verwenden
Bromfenac is a non-steroidal anti-inflammatory agent.
Definition
ChEBI: The sesquihydrate of the sodium salt of bromfenac. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction.
Bromfenac Sodium Upstream-Materialien And Downstream Produkte