Theobromin
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Theobromin Eigenschaften
- Schmelzpunkt:
- 345-350 °C
- Siedepunkt:
- 312.97°C (rough estimate)
- Dichte
- 1.50
- Brechungsindex
- 1.6700 (estimate)
- FEMA
- 3591 | THEOBROMINE
- Flammpunkt:
- 290-295°C
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- H2O: slightly soluble
- Aggregatzustand
- solid
- pka
- 7.89(at 18℃)
- Farbe
- white
- Geruch (Odor)
- odorless
- Wasserl?slichkeit
- slightly soluble, <0.1 g/100 mL at 18 ºC
- Sublimation
- 290-295 ºC
- Merck
- 14,9282
- BRN
- 16464
- InChIKey
- YAPQBXQYLJRXSA-UHFFFAOYSA-N
- LogP
- -0.78
- CAS Datenbank
- 83-67-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 51) 1991
- NIST chemische Informationen
- 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-(83-67-0)
- EPA chemische Informationen
- Theobromine (83-67-0)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn,Xi,T,F | ||
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R-S?tze: | 22-36/37/38-39/23/24/25-23/24/25-11 | ||
S-S?tze: | 22-24/25-36-26-45-36/37-16-7 | ||
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | ||
WGK Germany | 1 | ||
RTECS-Nr. | XH2275000 | ||
F | 10-23 | ||
TSCA | Yes | ||
HS Code | 29399990 | ||
Giftige Stoffe Daten | 83-67-0(Hazardous Substances Data) |
Bildanzeige (GHS) |
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Sicherheit |
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Theobromin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist (IC50s = 200-280 μM in radioligand binding assays using rat brain membranes). Theobromine (150 μg/ml) increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium. It inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent reactive oxygen species (ROS) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day. Theobromine is toxic to dogs with an LD50 value of 250 to 500 mg/kg.Chemische Eigenschaften
A methyl xanthine similar to caffeine. Theobromine has a bitter taste.Occurrence
Reported found in cocoa bean, cocoa powder, cola nut and tea.Definition
ChEBI: A dimethylxanthine having the two methyl groups located at positions 3 and 7. It is a purine alkaloid derived from cocoa tree.Allgemeine Beschreibung
Odorless white crystalline powder. Bitter taste. pH (saturated solution in water): 5.5-7.Air & Water Reaktionen
Insoluble in water.Reaktivit?t anzeigen
Theobromine may be sensitive to prolonged exposure to light. Theobromine has weakly acidic properties, combining with bases to forms salts. Theobromine also has even weaker basic properties, combining with acids to form salts which are decomposed in aqueous solution. .Hazard
Toxic by ingestion. Questionable carcinogen.Brandgefahr
Flash point data for Theobromine are not available; however, Theobromine is probably combustible.Sicherheitsprofil
Poison by ingestion. Moderately toxic by subcutaneous route. An experimental teratogen. Human systemic effects by ingestion: central nervous system and gastrointestinal changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Used as a diuretic, smooth muscle relaxant, cardiac stimulant, and vasoddator.l?uterung methode
It crystallises from H2O. Its solubility in H2O is 0.06% at 15o and 1.25% at 100o, and it is poorly soluble in organic solvents. It forms salts with heavy metals and is a diuretic, vasodilator and a cardiac stimulant. [Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp254-225 1971, ISBN 0-471-38205-1, Beilstein 26 H 457, 26 I 135, 26 II 264, 26 III/IV 2336.]Einzelnachweise
Biltz, Max., Annalen, 423,320 (1921)Dubosc., Chem. Zentr., IV, 956 (1932)
Gepner, Kreps., Chem. Abstr., 41,96 (1947)
Bohinc, Korber-Smid, J agodic., Farm. Vestn., (Ljubljana), 23, 143 (1972)
Theobromin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Theobromin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 529)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hengshui Haoye Co.,Ltd. | +86-0318-2102300 +8618632882519 |
hy@haoyecom.cn | China | 307 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 |
allison@yan-xi.com | China | 5855 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 3007 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 146 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10986 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20244 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29730 | 60 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29863 | 58 |
83-67-0(Theobromin)Verwandte Suche:
Dimethyl ether
Dimethylsulfoxid
Dimethyl sebacate
Acetonoxim
2,6-Dimethyloct-7-en-2-ol
Purin-2(3H),6(1H)-dion
1,2,3,4-Tetrahydronaphthalin-2-on
N,N-Dimethylformamid
Spartein
Epiandrosterone acetate
Tetrahydro-4H-pyran-4-on
Purin
Dimethylfumarat
Prasteron
Dimethylphthalat
Dimethylcarbonat
Ethan
Pentoxifyllin
- 3,7-dihydro-3,7-dimethyl-1h-purine-6-dione
- 3,7-dimethyl-xanthin
- 6-dione,3,7-dihydro-3,7-dimethyl-1H-Purine-2
- Diurobromine
- Santheose
- SC 15090
- sc15090
- Teobromin
- Theosalvose
- Theostene
- Thesal
- Theobromine solution
- Cocoa Extract/Theobromine
- 3,7-dihydro-3,7-dimethyl-1h-purine-2,6-dione
- Theobromide
- THEOBROMINE CRYSTALLINE
- 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-
- 3,7-dimethylpurine-2,6-dione
- THEOBROMINE(SH)
- THEOBROMINE[2,6-DIHYDROXY-3,7-DIMETHYL-PURINE]
- 3,7-DIMETHYLXANTHINE NF
- NSC 5039
- Thesodate
- Xanthine, 3,7-dimethyl-
- LABOTEST-BB LT00000138
- FEMA 3591
- AKOS 91967
- 3,7-Dimethylxanthine-[13C4,15N3] (Theobromine)
- TheobroMine, EP
- TheobroMine (3,7-DiMethylxanthine)
- 2,6-Dihydroxy-3,7-dimethylpurine, 3,7-Dimethylxanthine
- THEOBROMINE,100/MLINMETHANOL
- Theobromine,99%
- Theobromine
- Theobromine,2,6-Dihydroxy-3,7-dimethylpurine, 3,7-Dimethylxanthine
- Methanol(Test:Theobromine,100 ug/mL)
- Theophylline-ethylenediamine EP Impurity G
- Caffeine Impurity D
- Theophylline-ethylenediamine Impurity 7(Theophylline-ethylenediamine EP Impurity G)
- Theobromine Solution, 100ppm
- Theobromine, 98%, bronchodilator and vasodilator
- High Purity Theobromine manufacturer CAS NO.83-67-0
- Caffeine Impurity 4(Caffeine EP Impurity D)
- Pentoxifylline Impurity 1(Pentoxifylline EP Impurity A)
- Theobromine CRS
- Theobromine (Theophylline-ethylenediamine EP Impurity G, Caffeine EP Impurity D)
- Theobromine USP/EP/BP
- 3,7-dihydro-3
- 3,7-Dihydro-3,7-Dimethyl-lH-purine-2,6-Dione or Theobromine
- Pentoxifylline EP Impurity A (Theobromine)
- Theobromine cacao extract
- Theobromin
- 2,6-DIHYDROXY-3,7-DIMETHYL-PURINE
- 3,7-dimethyl-1H-purine-2,6(3H,7H)-dione
- 3,7-DIMETHYLXANTHINE
- 3,7-Dimethyl-3,7-dihydro-1H-purine-2,6-dione
- g . 3,7-d i me th yl-3,7-d i h yd ro-1h -puri ne -2,6-d i one (th e ob romi ne ).
- 13C,2H3]-Theobromine