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Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat

Metamizole sodium Struktur
68-89-3
CAS-Nr.
68-89-3
Bezeichnung:
Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat
Englisch Name:
Metamizole sodium
Synonyma:
METAMIZOLE;DIPYRONE;METAMIZOL SODIUM;SODIUM DIPYRONE;DIPYRONE SODIUM;novaminsulfon;novaminsulfone;sulpyrin;metamizolum;METAMIZOL SODIUM MONOHYDRATE
CBNumber:
CB7741339
Summenformel:
C13H16N3NaO4S
Molgewicht:
333.34
MOL-Datei:
68-89-3.mol

Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Eigenschaften

Schmelzpunkt:
227 °C
Dichte
1.388 g/cm3
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
Farbe
Minute crystals
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
CAS Datenbank
68-89-3(CAS DataBase Reference)
NIST chemische Informationen
Dipyrone(68-89-3)
EPA chemische Informationen
Methanesulfonic acid, 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-, sodium salt (1:1) (68-89-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 42/43
S-S?tze: 36
WGK Germany  2
RTECS-Nr. PB1300000
HS Code  29331920
Toxizit?t LD50 orl-rat: 3 g/kg ARZNAD 21,719,71
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

solid

Verwenden

A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.

Definition

ChEBI: An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.

Weltgesundheitsorganisation (WHO)

Metamizole sodium, a pyrazolone derivative with analgesic, antipyretic and antinflammatory activity, was introduced in 1921 and has since been widely available in over-the-counter products. By the early 1970s its use had been associated, as with some other pyrazolones, with serious and sometimes fatal adverse reactions, notably cases of blood dyscrasias including agranulocytosis, which led to its withdrawal by some regulatory authorities. Although preparations of metamirole sodium are prohibited in certain countries, they remain widely available in others and, in some cases, in over-the-counter products.

Sicherheitsprofil

Poison by subcutaneous route. Moderately toxic by several other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. See also SULFONATES. When heated to decomposition it emits very toxic fumes of NOx,, Na2O, and SOx,.

Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 303)Lieferanten
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68-89-3(Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat)Verwandte Suche:


  • nevralgina
  • noramidopyrinemethanesulfonatesodium
  • noramidopyrinium-methanesulphatenatrium
  • noraminopyrinemethanesulfonatesodium
  • optalgin
  • paralgin
  • phenyldimethylpyrazolonmethylaminomethanesodiumsulfonate
  • pyralgin
  • pyretin
  • pyrojec
  • sodium1-phenyl-2,3-dimethyl-4-methylaminopyrazolon-n-methanesulfonate
  • sodium1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate
  • sodium4-methylamino-1,5-dimethyl-2-phenyl-3-pyrazolone4-methanesulfonate
  • sodiummethylaminoantipyrinemethanesulfonate
  • sodiumnoramidopyrinemethanesulfonate
  • sodiumphenyldimethylpyrazolon-methylamino-methanesulfonate
  • sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1h-pyrazol-4-yl)methylamino]methanesulfonate
  • Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonate
  • Alangin
  • Analgin(metamizole)
  • Analgin/MetamizoleSodium
  • Dipyrone(MetamizoleSodium
  • BENZALAGEN
  • LABOTEST-BB LT00771955
  • metamizole sodium
  • Methanesulfonic acid, (2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino-, sodium salt
  • [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylamino] methanesulphonate
  • Dipyrone Hcl / Analgin
  • NoramidopyrineMethanesulfonatSodium
  • N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-N-methylamino methanesulfoxylote sodium salt
  • Analgin sodium
  • N-Methyl-N-(2,3-dihydro-1,5-dimethyl-2-phenyl-3-oxo-1H-pyrazol-4-yl)aminomethanesulfonic acid sodium
  • NSC-73205
  • 1-[(2,3-Dihydro-1,5-diMethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)MethylaMino]Methanesulfonic Acid SodiuM Salt
  • Algopyrin
  • Anador
  • Andolor
  • ARPF
  • Gifaril
  • Lisador
  • MethaMizole SodiuM
  • Metilon
  • Sulpin
  • analgin API
  • METAMIZOLE SODIUM MONOHYDRATE PH EUR
  • 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolon-n-methanesulfonsaeurennatriu
  • 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonatesodium
  • 1-phenyl-2,3-dimethylpyrazolone-(5)-4-methylaminomethanesulfonicacidsodium
  • 4-methylamino-1,5-dimethyl-2-phenyl-3-pyrazolonesodiummethanesulfonate
  • 4-sodiummethanesulfonatemethylamine-antipyrine
  • alginodia
  • algocalmin
  • methylaminoantipyrinesodiummethanesulfonate
  • methylaminophenyldimethylpyrazolonemethanesulfonatesodium
  • methylmelubrin
  • methylmelubrine
  • narone
  • neomelurbrin
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