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4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Struktur
1884640-99-6
CAS-Nr.
1884640-99-6
Englisch Name:
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
Synonyma:
NI-42 >=98% (HPLC);BRPF1 inhibitor NI-42;NI-42,Inhibitor,inhibit,NI 42,Epigenetic Reader Domain,NI42;4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide;4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide;Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-
CBNumber:
CB74902796
Summenformel:
C18H15N3O3S
Molgewicht:
353.39
MOL-Datei:
1884640-99-6.mol

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Eigenschaften

Siedepunkt:
554.6±60.0 °C(Predicted)
Dichte
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
Aggregatzustand
A crystalline solid
pka
8.05±0.20(Predicted)

Sicherheit

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid leukemia (AML) cells (GI50s = 1.3, 4.6, 5.7, 7, and 9.9 μM, respectively) and a variety of non-AML cells (GI50s = 1-10 μM). It also inhibits the growth of DMS114 lung, HRA-19 colon, and RERF-LC-Sq1 lung cancer cells (GI50s = 16.6, 15.6, and 17.1 μM, respectively) but not NCI H1703 lung cancer cells (GI50 = >30 μM).

Verwenden

NI-42 is a new chemical probe for the BRPFs (bromodomain and PHD finger-containing) suitable for cellular and invivo studies to explore the fundamental biology of these proteins.

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 40)Lieferanten
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Anqing YanZhi Pharma Discovery Co.,Ltd. 18055651951
 2272561977@qq.com China 418 58
  • 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
  • BRPF1 inhibitor NI-42
  • NI-42 >=98% (HPLC)
  • NI-42,Inhibitor,inhibit,NI 42,Epigenetic Reader Domain,NI42
  • Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-
  • 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide
  • 1884640-99-6
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