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4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide

化學(xué)構(gòu)造式
1884640-99-6
CAS番號.
1884640-99-6
化學(xué)名:
別名:
英語名:
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
英語別名:
NI-42 >=98% (HPLC);BRPF1 inhibitor NI-42;NI-42,Inhibitor,inhibit,NI 42,Epigenetic Reader Domain,NI42;4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide;4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide;Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-
CBNumber:
CB74902796
化學(xué)式:
C18H15N3O3S
分子量:
353.39
MOL File:
1884640-99-6.mol

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide 物理性質(zhì)

沸點(diǎn) :
554.6±60.0 °C(Predicted)
比重(密度) :
1.43±0.1 g/cm3(Predicted)
貯蔵溫度 :
Store at -20°C
溶解性:
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
外見 :
A crystalline solid
酸解離定數(shù)(Pka):
8.05±0.20(Predicted)

安全性情報

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide 価格

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide 化學(xué)特性,用途語,生産方法

説明

NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid leukemia (AML) cells (GI50s = 1.3, 4.6, 5.7, 7, and 9.9 μM, respectively) and a variety of non-AML cells (GI50s = 1-10 μM). It also inhibits the growth of DMS114 lung, HRA-19 colon, and RERF-LC-Sq1 lung cancer cells (GI50s = 16.6, 15.6, and 17.1 μM, respectively) but not NCI H1703 lung cancer cells (GI50 = >30 μM).

使用

NI-42 is a new chemical probe for the BRPFs (bromodomain and PHD finger-containing) suitable for cellular and invivo studies to explore the fundamental biology of these proteins.

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide 上流と下流の製品情報

原材料

準(zhǔn)備製品

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide 生産企業(yè)

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  • 1884640-99-6
  • 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
  • BRPF1 inhibitor NI-42
  • NI-42 >=98% (HPLC)
  • NI-42,Inhibitor,inhibit,NI 42,Epigenetic Reader Domain,NI42
  • Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-
  • 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide
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