Methylphenothiazin-2-ylketon
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- CAS-Nr.
- 6631-94-3
- Bezeichnung:
- Methylphenothiazin-2-ylketon
- Englisch Name:
- 2-Acetylphenothiazine
- Synonyma:
- 2-APT;ML 171;2-Acetylphenothiazin;2-ACETYLPHENOTHIAZINE;NOX1 Inhibitor, ML171;LABOTEST-BB LT00012652;2-Acetyl-10H-phenothiazine;2-Acetylphenothiazine(ML171);methyl phenothiazin-2-yl ketone;Ethanone, 1-(10H-phenothiazin-2-yl)-
- CBNumber:
- CB7368424
- Summenformel:
- C14H11NOS
- Molgewicht:
- 241.31
- MOL-Datei:
- 6631-94-3.mol
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Methylphenothiazin-2-ylketon Eigenschaften
- Schmelzpunkt:
- 180-185 °C (lit.)
- Siedepunkt:
- 455.7±34.0 °C(Predicted)
- Dichte
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- -2.45±0.20(Predicted)
- Aggregatzustand
- Dark yellow-orange powder
- Farbe
- Yellow to Dark Orange
- maximale Wellenl?nge (λmax)
- 244nm(MeOH)(lit.)
- CAS Datenbank
- 6631-94-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22-52/53 |
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| S-S?tze: |
60-61 |
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| WGK Germany |
3 |
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| HS Code |
2934309090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H412 |
Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Methylphenothiazin-2-ylketon Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC
50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC
50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.
Chemische Eigenschaften
Yellow white or green crystalline powder
Verwenden
2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
Methylphenothiazin-2-ylketon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methylphenothiazin-2-ylketon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 175)Lieferanten
6631-94-3(Methylphenothiazin-2-ylketon)Verwandte Suche:
- 2-ACETYLPHENOTHIAZINE
- methyl phenothiazin-2-yl ketone
- 2-Acetyl-10H-phenothiazine
- 2-Acetylphenothiazin
- 1-(10H-Phenothiazin-2-yl)ethan-1- one, 2-Ethanoyl-10H-phenothiazine
- ML 171
- LABOTEST-BB LT00012652
- NOX1 Inhibitor, ML171
- 2-Acetylphenothiazine(ML171)
- NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem
- 2-APT
- Ethanone, 1-(10H-phenothiazin-2-yl)-
- 6631-94-3
- C14H11NOS
- Thiazines
- Heterocyclic Building Blocks
- Building Blocks
- Building Blocks
- Heterocyclic Building Blocks
- Thiazines
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
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