6631-94-3
6631-94-3 結(jié)構(gòu)式
基本信息
LABOTEST-BB LT00012652
methyl phenothiazin-2-yl ketone
2-Acetyl-10H-phenothiazine
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-12805 | 2-乙?；脏玎?BR>ML171 | 6631-94-3 | 100mg | 200元 |
| 2024/11/08 | HY-12805 | 2-乙?；脏玎?BR>ML171 | 6631-94-3 | 10mM * 1mLin DMSO | 220元 |
| 2024/11/08 | A2815 | 2-乙?；脏玎?BR>2-Acetylphenothiazine | 6631-94-3 | 5g | 390元 |
常見問題列表
| Target | Value |
|
NOX1
(HEK293) | 0.25 μM |
|
NOX3
(HEK293) | 3 μM |
|
NOX2
(HEK293) | 5 μM |
|
NOX4
(HEK293) | 5 μM |
|
xanthine oxidase
(HEK293) | 5.5 μM |
Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC 50 =0.129 μM) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation caused by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is tested in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound.