6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat
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- CAS-Nr.
- 427-51-0
- Bezeichnung:
- 6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat
- Englisch Name:
- Cyproterone acetate
- Synonyma:
- ANDROCUR;CYPROSTAT;CIPROTERONE ACETATE;SH-714;nsc-81430;Cyproviron;cyprosteroneacetate;CYPROTERONE ACETATE;CYPROFERONE ACETATE;cyproteron-racetate
- CBNumber:
- CB7338955
- Summenformel:
- C24H29ClO4
- Molgewicht:
- 416.94
- MOL-Datei:
- 427-51-0.mol
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6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Eigenschaften
- Schmelzpunkt:
- 200-201°C
- Siedepunkt:
- 528.8°C (rough estimate)
- Dichte
- 1.0677 (rough estimate)
- Brechungsindex
- 1.4429 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol.
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- maximale Wellenl?nge (λmax)
- 281nm(MeOH)(lit.)
- Merck
- 14,2774
- InChIKey
- UWFYSQMTEOIJJG-KIXORDEXNA-N
- SMILES
- C[C@@]12C(=CC(=O)[C@@H]3C[C@H]13)C(Cl)=C[C@@]1([H])[C@]3([H])CC[C@@](C(=O)C)(OC(=O)C)[C@@]3(C)CC[C@]21[H] |&1:1,6,8,12,14,18,26,30,r|
- EPA chemische Informationen
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Cyproterone acetate (CPA) is an androgen receptor antagonist. It binds to human androgen receptors (K
i = 14 nM) and inhibits dihydrotestosterone-induced androgen receptor activation in CV-1 cells (IC
50 = 26 nM). CPA (30 mg/kg) decreases ventral prostate weight in castrated immature rats. It also suppresses accessory sexual glands and fertility in adult male rats when administered at a dose of 10 mg/kg. CPA (0.3 μM) also induces apoptosis in primary adult female rat hepatocytes. Formulations containing cyproterone acetate have been used in the treatment of androgenization in females.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Cyproterone acetate (CPA) has been shown to exert gestagenic and glucocorticoid effects. Because it inhibits the negative diencephalic pituitary testicular feedback system, it lowers luteinizing hormone (LH) and testosterone production and plasma levels. cyproterone acetate is both an anti-androgen and a progestogen. CPA is used in combined birth control pills, in the treatment of androgen-dependent skin and hair conditions such as acne (Combined with estrogen), seborrhea, excessive hair growth, and scalp hair loss, high androgen levels, in transgender hormone therapy, to treat prostate cancer, to reduce sex drive in sex offenders or men with paraphilias or hypersexuality, to treat early puberty, and for other uses. It is used both at low doses and at higher doses.
Indications
Cyproterone acetate is a progestational antiandrogen
that blocks androgen receptor binding and suppresses
androgen-sensitive tissues. It is available in a
topical form in Europe for the treatment of hirsutism.
6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 425)Lieferanten
427-51-0(6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat)Verwandte Suche:
2-Methoxy-1-methylethylacetat
Methylacetat
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ylacetat
Leuprorelin acetate
2-Ethoxy-ethylacetat
Vinylacetat
Glatiramer acetate
POLY(VINYL ACETATE)
2-Butoxy-ethylacetat
Isopropylacetat
Natriumacetat
Ethylacetat
n-Butylacetat
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Chlormadinonacetat
ACETATE
Cyproterone
(7E,9Z)-Dodecadienyl acetat
- cyprosteroneacetate
- 1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio
- 1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat
- 1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate
- 17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio
- 20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3
- 6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4
- 6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
- 6-chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup6)-progesteroneaceta
- 6-chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesteroneacetate
- 6-chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dioneacet
- 6-chloro-delta(sup6)-1,2-alpha-methylene-17-alpha-hydroxyprogesteroneacetat
- CYPROTERONE ACETATE
- CYPROFERONE ACETATE
- 6-CHLORO-1BETA,2BETA-DIHYDRO-17-HYDROXY-3'H-CYCLOPROPA[1,2]-PREGNA-1,4,6-TRIENE-3,20-DIONE ACETATE
- 6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
- 4,6-PREGNADIEN-6-CHLORO-1-ALPHA, 2-ALPHA-METHYLENE-17-OL-3,20-DIONE ACETATE
- cyproterone17-alpha-acetate
- cyproteron-racetate
- nsc-81430
- Cyproterone Acetate BP2000,EP2000
- 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
- Androcur, Cyprostat
- 3H-Cyclopropa1,2pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)-
- 6-Chloro-1α,2α-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate
- CyproteroneAcetateedmfep5
- CyproteroneAcetateEdmf
- 6-Chloro-1β,2β-dihydro-17-hydroxy-3μH-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
- Androcurone acetate
- SH-714
- Cyproterone acetate(Androcur)
- Cyproviron
- (1β,2β)-17-(acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
- Cyproterone acetate for peak identification
- * Color Pronk (cyproterone)
- Cyproterone D3 Acetate
- Cyproterone acetate, 98%, an androgen receptor (AR) antagonist
- Cyproterone acetate CRS
- Cyproterone acetate for peak identification CRS
- Cyproterone Acetate >
- Cyproterone 17-O-acetate
- 6-Chloro-3,20-dioxo-1β,2β-dihydro-3′H-cyclopropa-[1,2]pregna-1,4,6-trien-17-yl acetate
- (1aR,5aR,5bS,8R,8aS,9aS,9bS,9cS)-8-Acetyl-4-chloro-8a,9b-dimethyl-2-oxo-1a,2,5a,5b,6,7,8,8a,9,9a,9b,9c-dodecahydro-1H-cyclopropa[a]pentaleno[1,2-h]naphthalen-8-yl acetate
- Cyproterone acetate USP/EP/BP
- Cyproterone Acetate-13C,d3
- Cyproterone acetateQ: What is
Cyproterone acetate Q: What is the CAS Number of
Cyproterone acetate Q: What is the storage condition of
Cyproterone acetate Q: What are the applications of
Cyproterone acetate
- Cyproterone acetate (C3283000)
- Cyproterone Acetate D3Q: What is
Cyproterone Acetate D3 Q: What is the CAS Number of
Cyproterone Acetate D3 Q: What is the storage condition of
Cyproterone Acetate D3 Q: What are the applications of
Cyproterone Acetate D3
- CIPROTERONE ACETATE
- ANDROCUR
- CYPROSTAT
- Cyproterone acetate API
- Cyproterone acetate chloride
- Cyproterone (+)-bitartrate salt
- 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1β,2β)-
- 4, 6-PREGNADIEN-6-CHLORO-1α, 2α-METHYLENE-17-OL-3, 20-DIONE ACETATE
- (2aR,3aS,3bS,3cS,5aS,6R,8aS,8bR)-6-acetyl-10-chloro-3b,5a-dimethyl-2-oxo-2,2a,3,3a,3b,3c,4,5,5a,6,7,8,8a,8b-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-6-yl acetate
- 427-51-0
