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Teduglutide

Teduglutide Struktur
197922-42-2
CAS-Nr.
197922-42-2
Englisch Name:
Teduglutide
Synonyma:
Gattex;TAK 633;ALX 0600;Revestive;Teduglutide;Teduglutide GLP-2;ALX 0600 USP/EP/BP;Teduglutide(ALX-0600);TIANFU 197922-42-2 Teduglutide;Glucagon-like peptide II [2-glycine] (human)
CBNumber:
CB72514601
Summenformel:
C164H252N44O55S
Molgewicht:
3752.08248
MOL-Datei:
197922-42-2.mol

Teduglutide Eigenschaften

L?slichkeit
Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
Stabilit?t:
Hygroscopic
InChIKey
CILIXQOJUNDIDU-ASQIGDHWSA-N

Sicherheit

Giftige Stoffe Daten 197922-42-2(Hazardous Substances Data)

Teduglutide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Teduglutide was approved in August 2012 by the European Commission and in December 2012 by the US FDA for the treatment of adults with short bowel syndrome (SBS) who are dependent on parenteral nutrition (PN). Teduglutide (also known as ALX-0600) is a GLP-2 analogue in which glycine has been substituted for alanine at position 2 from the N-terminus, thereby conferring resistance to degradation by DPP-4. Teduglutide has similar binding affinity, agonist potency, and agonist efficacy as GLP-2 in assays with the rat GLP-2 receptor. Administration of teduglutide to rats gave a significant increase in small intestine weight and an increase in the height of intestinal villi. Teduglutide was prepared by solid-phase peptide synthesis.

Verwenden

Treatment of intestinal diseases characterized by chemical or surgical damage of the intestinal epithelium such as Short Bowel Syndrome (SBS) or damage to the intestinal epithelium due to disease (glucagon-like peptide-2 (GLP- 2) analog).

Definition

ChEBI: A 33-membered polypeptide consisting of His, Gly, Asp, Gly, Ser, Phe, Ser, Asp, Glu, Met, Asn, Thr, Ile, Leu, Asp, Asn, Leu, Ala, Ala, Arg, Asp, Phe, Ile, Asn, Trp, Leu, Ile, Gln, Thr, Lys, Ile, Thr and Asp residues joined in sequence. A glucagon-like pep ide-2 receptor agonist used for the treatment of short-bowel syndrome.

Application

Teduglutide is a peptide hormone that is used to treat pediatric patients with long-term efficacy. It has been shown to be effective in the treatment of autoimmune diseases and bowel disease. It is a long-acting analogue of glucagon-like peptide 1 (GLP-1). The drug has been shown to have high chemical stability, which means it does not break down easily. Teduglutide is injected into the body and taken up by cells, where it activates receptors on the surface of cells. This activation leads to increased glucose production by the liver and improved insulin sensitivity in peripheral tissues such as muscle, fat, and liver. It also increases heart rate and blood pressure.

Mechanism of action

Gattex (teduglutide) is an analog of naturally occurring human glucagon-like peptide 2 (GLP-2), a peptide secreted primarily in the distal intestine and involved in the regeneration and repair of the intestinal epithelium. GLP-2 is known to increase intestinal and portal blood flow, and inhibit gastric acid secretion.Teduglutide binds to the GLP-2 receptors located in intestinal subpopulations of enteroendocrine cells, subepithelial myofibroblasts and enteric neurons of the submucosal and myenteric plexus. Activation of these receptors results in the local release of multiple mediators including insulin-like growth factor (IGF)-1, nitric oxide and keratinocyte growth factor (KGF).

Nebenwirkungen

Side effects that you should report to your care team as soon as possible:
Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting
Gallbladder problems—severe stomach pain, nausea, vomiting, fever
Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting

Teduglutide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Teduglutide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 149)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Jiafan Trading Company Limited
+8615354498258
sales01@jiafan88.com China 61 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Shanghai Likang New Materials Co., Limited
+86-16631818819 +86-17736933208
3684455296@qq.com China 9300 58
Shandong Huizhihan Supply Chain Co., Ltd
+8613363081709
3957328362@qq.com China 300 58
Shanghai Yunao International Trade Co., Ltd
+8617621705551
asdf@shanghaihg.cn China 264 58
Hebei Lingding Biotechnology Co., Ltd.
+86-18031140164 +86-19933155420
erin@hbldbiotech.com China 61 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Shandong Hanjiang Chemical Co., Ltd
+86-0533-2066820 +8618369939125
hanson@sdhanjiang.com China 997 58

197922-42-2()Verwandte Suche:


  • ALX 0600
  • Gattex
  • Glucagon-like peptide II [2-glycine] (human)
  • Teduglutide
  • ALX 0600 USP/EP/BP
  • TIANFU 197922-42-2 Teduglutide
  • Teduglutide(ALX-0600)
  • Revestive
  • TAK 633
  • Teduglutide GLP-2
  • 197922-42-2
  • C164H252N44O55S
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