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42-(Dimethylphosphinate)rapamycin

42-(Dimethylphosphinate)rapamycin Struktur
572924-54-0
CAS-Nr.
572924-54-0
Englisch Name:
42-(Dimethylphosphinate)rapamycin
Synonyma:
Ridaforolimus;Deforolimus;DeforoliMus API;Ridaforolimus, >RidaforoliMus, >80%;DeforoliMus(MK-8669);Deforolimus (AP23573);deforolimus 572924-54-0;Ridaforolimus (MK-8669);Deforolimus (AP23573)42-
CBNumber:
CB72462148
Summenformel:
C53H84NO14P
Molgewicht:
990.21
MOL-Datei:
572924-54-0.mol

42-(Dimethylphosphinate)rapamycin Eigenschaften

Schmelzpunkt:
95-98°C
Siedepunkt:
996.2±75.0 °C(Predicted)
Dichte
1.18±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
10.40±0.70(Predicted)
Farbe
Off-White to Pale Yellow
Stabilit?t:
Hygroscopic
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P273 Freisetzung in die Umwelt vermeiden.
P314 Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.
P391 Verschüttete Mengen aufnehmen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

42-(Dimethylphosphinate)rapamycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MK-8669 is a rapamycin analog that selectively inhibits mTOR (IC50 = 0.2 nM). Like rapamycin, MK-8669 binds FKBP12 to form a complex that associates with the FKBP-rapamycin binding domain on mTOR and allosterically inhibits mTORC1 kinase activity. MK-8669 is more water soluble than rapamycin and is amenable to oral or intravenous administration. Formulations containing rapalogs, including MK-8669, have promise against a subset of cancers, including advanced kidney cancer. MK-8669 is also being examined for effectiveness against cancers when used in combination with other chemotherapeutic compounds.

Chemische Eigenschaften

Off-White Solid

Definition

ChEBI: A semisynthetic derivative that is sirolimus in which hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding dimethylphosphinate.

42-(Dimethylphosphinate)rapamycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

42-(Dimethylphosphinate)rapamycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 136)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9220 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293
 sales@sdzschem.com China 2930 58
NanJing Spring & Autumn Biological Engineering CO., LTD. 		+8613815430202
 sale02@cqherb.com CHINA 376 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018
ramyan@ex-biotech.com CHINA 954 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD 		+8615377521700
 wangwendy93@gmail.com China 868 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040
 sales@myuchem.com China 7388 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626
 eric@witopchemical.com China 23541 58

572924-54-0()Verwandte Suche:

  • RidaforoliMus, >80%
  • DeforoliMus(AP 23573,MK-8669,RidaforoliMus)
  • DeforoliMus (RidaforoliMus)
  • RidaforoliMus (DeforoliMus, MK-8669)
  • DeforoliMus API
  • DeforoliMus(MK-8669)
  • RapaMycin 42-(DiMethylphosphinate)
  • AP 23573, MK 8669, 42-DiMethylphosphinate-rapaMycin
  • RapaMycin,42-(diMethylphosphinate) (9CI)
  • Deforolimus (AP23573)42-
  • 42-(Dimethylphosphinate)rapamycin
  • Deforolimus
  • Deforolimus (AP23573, MK-8669)
  • Deforolimus (AP23573)
  • AP23573; MK-8669; RIDAFOROLIMUS; AP 23573; MK 8669; AP-23573; MK8669
  • deforolimus 572924-54-0
  • Deforolimus, 98%, a potent and selective mTOR inhibitor
  • Ridaforolimus Deforolimus
  • Ridaforolimus, >
  • 42-(Dimethylphosphinate)rapamycin USP/EP/BP
  • Ridaforolimus (Deforolimus, MK8669, AP23573)
  • Ridaforolimus (MK-8669)
  • Ridaforolimus
  • Deforolimus/MK-8669/AP23573
  • (1R,2R,4S)-4-((R)-2-((3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-Dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontin-3-yl)propyl)-2-methoxycyclohexyl dimethylphosphinate
  • 572924-54-0
  • C53H84NO14P
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API
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