Mycophenolins?ure
|
|
Mycophenolins?ure Eigenschaften
- Schmelzpunkt:
- 141°C
- Siedepunkt:
- 419.24°C (rough estimate)
- Dichte
- 1.2300 (rough estimate)
- Dampfdruck
- 0Pa at 22℃
- Brechungsindex
- 1.5200 (estimate)
- Flammpunkt:
- 2℃
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- methanol: 50 mg/mL, clear, colorless to faintly yellow
- Aggregatzustand
- powder
- pka
- 4.5(at 25℃)
- Farbe
- white to white with yellow cast
- Wasserl?slichkeit
- 13mg/L(25 ºC)
- Merck
- 14,6327
- BRN
- 1295848
- BCS Class
- 2?
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- LogP
- -1.83-2.28 at 25℃ and pH5-9
- Dissoziationskonstante
- 4.58-8.05 at 22.5-25℃
- CAS Datenbank
- 24280-93-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn,N,T,F | ||
---|---|---|---|
R-S?tze: | 22-61-40-68-50/53-48/25-52/53-36-20/21/22-11 | ||
S-S?tze: | 53-45-36/37-61-22-26-16 | ||
RIDADR | 2811 | ||
WGK Germany | 3 | ||
RTECS-Nr. | MP8050000 | ||
F | 10 | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29419090 | ||
Toxizit?t | LD50 in mice (mg/kg): >1250 orally; 972.9±77 i.p. (Williams) |
Bildanzeige (GHS) |
![]() ![]() ![]() |
|||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alarmwort | Achtung | |||||||||||||||||||||||||||||||||||
Gefahrenhinweise |
|
|||||||||||||||||||||||||||||||||||
Sicherheit |
|
Mycophenolins?ure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R61:Kann das Kind im Mutterleib sch?digen.
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Mycophenolic acid is an immunosuppresive microbial metabolite that has been found in P. brevicompactum. It is also an active metabolite of mycophenolate mofetil that is formed via carboxylesterase 1 (CES1) and CES2. Mycophenolic acid is an inhibitor of IMP dehydrogenase (IMPDH) type I and type II (IC50s = 32 and 11 nM, respectively, in cell-free assays) and inhibits DNA synthesis in L strain mouse fibroblasts when used at concentrations ranging from 0.1 to 10 μg/ml. It is active against several strains of C. albicans, C. parakrusei, C. tropicalis, and C. neoformans (MICs = 3.9-31.25 μg/ml), as well as various strains of S. aureus (MICs = 31.25-125 μg/ml). Mycophenolic acid (150 mg/kg) reduces splenomegaly in a mouse model of Friend virus-induced leukemia. It decreases the number of hemolytic plaque forming cells isolated from the spleen of mice immunized with sheep red blood cells (RBCs) when administered at doses ranging from 60 to 240 mg/kg. Formulations containing mycophenolic acid have been used as immunosuppressive agents in the prevention of organ transplant rejection.Chemische Eigenschaften
White to Off-White PowderVerwenden
Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation showed mycophenolic acid to display broad antitumour, antiviral, antifungal and antiprotozoan activities. Its potent immunosuppressant activity led to its commercial development to prevent kidney transplant rejection. Mycophenolic acid acts by inhibiting inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in proliferating B and T lymphocytes.Definition
ChEBI: A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mo etil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.Allgemeine Beschreibung
Assayed in therapeutic drug monitoring to ensure patients remain within the drug′s therapeutic range, mycophenolic acid is an immunosuppressant drug and the active metabolite of the prodrug mycophenolate mofetil. This analytical standard is suitable for LC-MS/MS applications including therapeutic drug monitoring and other clinical or diagnostic applications.Biologische Aktivit?t
Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo . Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.Mechanism of action
Mycophenolic acid (MPA) is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH) that prevents the ab initio biosynthesis of purine nucleotides. It predominantly affects lymphocytes, leading to inhibition of DNA synthesis in T cells and B cells, thereby suppressing cell-mediated immune responses and antibody formation.MPA also inhibits glycosylation and expression of adhesion molecules, as well as the recruitment of lymphocytes and monocytes to sites of inflammation.MPA depletes tetrahydrobiopterin and reduces nitric oxide production via inducible NO synthase without affecting the activity of constitutive NO synthase[1].l?uterung methode
Purify the acid by dissolving it in the minimum volume of EtOAc, applying onto a silica gel column (0.05-0.2 mesh) and eluting with a mixture of EtOAc/CHCl3/AcOH (45:55:1) followed by recrystallisation from heptane/EtOAc, from aqueous EtOH or from hot H2O and drying in vacuo. It is a weak dibasic acid, moderately soluble in Et2O, CHCl3 and hot H2O but weakly soluble in *C6H6 and toluene. [Birch & Wright Aust J Chem 22 2635 1969, Canonica et al. J Chem Soc, Perkin Trans 1 2639 1972, Birkinshaw et al. Biochem J 50 630 1952, Beilstein 18 II 393, 18 III/IV 6513.]Mycophenolins?ure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Mycophenolins?ure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 528)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Biopole Pharmatech Co., Ltd. | +8615151475053 |
biopole@163.com | China | 37 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
abby@chuanghaibio.com | China | 8808 | 58 |
Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12827 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5879 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33025 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29867 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2930 | 58 |
24280-93-1(Mycophenolins?ure)Verwandte Suche:
Zitronensure
ACETIC ACID
Salvianolic acid B
Anisol
Folsure
Stearinsure
(Trifluormethoxy)benzol
Methyl-4-hydroxybenzoat
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Bensulfuron methyl
Salvianolic acid
Anisaldehyd
Methylacrylat
4-Methoxy-anilin
Gibberellins?ure
Kresoxim-methyl
Thiophanat-methyl
ASCORBICACID
- 6-[4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-PHTHALANYL]-4-METHYL-4-HEXENOIC ACID
- 4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide
- 6-(5-carboxy-3-methyl-2-pentenyl)-7-hydroxy-5-methoxy-4-methyl-phthalid
- lilly-68618
- (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
- 68618
- Micophenolic acid
- Mycophenolic acid,6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
- 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid, 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid
- Mycophenolic acid/(E)-6-(4-hydroxy-6-Methoxy-7-Methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-Methylhex-4-enoic acid
- (4Z)-6-(4-hydroxy-6-Methoxy-7-Methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-Methylhex-4-enoic acid
- Mycophenolic acid(Mycophenolate)
- (E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid
- 6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-4-HEXENOIC ACID
- 6-(1,3-DIHYDRO-7-HYDROXY-5-METHOXY-4-METHYL-1-OXOISOBENZOFURAN-6-YL)-4-METHYL-4-HEXANOIC ACID
- MYCOPHENOLIC ACID
- mycophenolic acid from penicillium brevi-compactum
- mycophenolic acid from penicillium*brevi-compactu
- MYCOPHENOLIC ACID 98%
- 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (4E)-
- Mycophenolinsure
- Mycophenolic acid solution
- Mycophenolate Mofetil Impurity F(Mycophenolic Acid)
- Mycophenolic acid, >=98%
- SILVER NITRATE PROTEOMICS GRADE
- 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
- Mycophenolic acid (MPA)
- Melbex, Lilly 68618, NSC 129185
- Mycophenolic acid SynonyMs 6-(1,3-Dihydro-7-hydroxy-5-Methoxy-4-Methyl-1-oxoisobenzofuran-6-yl)-4-Methyl-4-hexanoic acid
- Mycophenolic acid 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid
- micofenolicoacido
- (4E)-6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-4-HEXENOIC ACID
- 6-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-PHTHALANYL)-4-METHYL-4-HEXANOIC ACID
- (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-4-hexenoate
- Mycophenolate Mofetil EP Impurity F/Mycophenolic Acid/(4E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
- Mycophenolate Mofetil Impurit F:Mycophenolic Acid((E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methy)
- Mycophenolic Acid - CAS 24280-93-1 - Calbiochem
- 5-Dimethyl-1-adamantanol
- Mycophenolate Mofetil EP Impurity F (Mycophenolic Acid)
- Mycophenol mofetile
- Mycophenolic Acid (10mM in DMSO)
- Mycophenolic acid USP/EP/BP
- Mycophenolic Acid Solution (100μg/ml Acetonitrile Solution)
- MycophenolicAcid>
- Mycophenolate Mofetil Impurity 6(Mycophenolate Mofetil EP Impurity F)
- MPA, mycophenolic acid
- (4E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
- (E)-6-(4-hydroxy-6-Methoxy-7-Methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-Methylhex-4-enoic acid
- Mycophenolic
- melbex
- nsc-129185
- MycophenoL
- Mycophenolate Mofetil EP Impurity F
- Mycophenolate Mofetil EP Impurity F(Mycophenolic acid (E) - isomer)
- Mycophenolate Impurity 19
- Mycophenolic Acid, ≥ 98.0%
- Mycophenolic acid in acetonitrile
- Mycophenolate Mofetil EP Impurity F pr Mycophenolic acid (E) - isomer