Mivacurium chloride
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- CAS-Nr.
- 106861-44-3
- Englisch Name:
- Mivacurium chloride
- Synonyma:
- (S)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline;Mivacron;BW-B1090U;rac-Mivacron;rac-BW-B 1090;rac-BW-B 1090U;Lomiwa Reservoir;BMS-512148 (2S)-1;MIVACURIUM CHLORIDE;Mivacarium Chloride
- CBNumber:
- CB7218031
- Summenformel:
- C58H80ClN2O14+
- Molgewicht:
- 1064.73
- MOL-Datei:
- 106861-44-3.mol
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Mivacurium chloride Eigenschaften
- alpha
- 20D -62.7° (c = 1.9 in water)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- L?slichkeit
- DMSO: Soluble; Water: Soluble
- Aggregatzustand
- A solid
- Farbe
- White to off-white
- Stabilit?t:
- Hygroscopic
- InChIKey
- KFWHZSUNFAPZPW-NVIAPQDINA-M
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Mivacurium chloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Mivacurium chloride,a mixture of three stereoisomers, is an intravenously
administered, short-acting skeletal muscle relaxant introduced as an adjunct to general
anesthesia. Structurally mivacurium chloride is closely related to doxacurium chloride
introduced in 1991 by Wellcome as a muscle relaxant. It is a nondepolarizing
neuromuscular blocking agent reportedly with a shorter duration of action and a more
rapid rate of spontaneous recovery than other nondepolarizing agents. In extensive
clinical trials mivacurium chloride was well tolerated with few side effects.
Chemische Eigenschaften
Off-White Solid
Verwenden
Non-depolarizing neuromuscular blocking agent. Muscle relaxant (skeletal)
Biologische Funktion
Mivacurium chloride (Mivacron) is a newer agent
that is chemically related to atracurium. The primary
mechanism of inactivation is hydrolysis by plasma
cholinesterase. Although it is useful for patients with
renal or hepatic disease, some caution is warranted,
since these individuals may have reduced plasma
cholinesterase as a result of the disease.Mivacurium has
an onset of action (1.8 minutes) and duration of effect
(20 minutes) only twice that of succinylcholine, and in
this respect, it is the most similar to succinylcholine of
all of the nondepolarizing agents.
Allgemeine Beschreibung
Mivacurium chloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, (E)-4-octandioate (Mivacron), is a mixture of three stereoisomers,the trans-trans, cis-trans, and cis-cis diesters, each ofwhich has neuromuscular blocking properties. The cis-cisisomer is about one tenth as potent as the other isomers.Mivacurium chloride is a short-acting nondepolarizing drugused as an adjunct to anesthesia to relax skeletal muscle.The drug is hydrolyzed by plasma esterases, and it is likelythat anticholinesterase agents used as antidotes could prolongrather than reverse the effects of the drug.
Mivacurium chloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Mivacurium chloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 125)Lieferanten
106861-44-3()Verwandte Suche:
- MIVACURIUM CHLORIDE
- rac Mivacurium Chloride
- rac-BW-B 1090
- rac-Mivacron
- rel-(1R,1'R)-2,2'-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]- isoquinolinium Chloride
- [R-[R*,R*-(E)]]2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinolinium] dichloride
- rac-BW-B 1090U
- -1，2，3，4-Te．trahydro-2-(3-hydroxypropyl)-6，7-dimethoxy-2-methyl-1-(3，4，5-trimethoxy-benzyl)isoquinolinium chloride，(E)-4-octenedioate(2：1)
- BW-B1090U
- Mivacron
- (1R,1'R)-2,2'-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-[(3,4,5-triMethoxyphenyl)Methyl]-isoquinoliniuM Chloride
- Mivacurium Chloride (mixture of isomers)
- Mivacurium Chloride (Mixture of Diastereomers)
- (R)-3-(6,7-dimethoxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-ol
- (R)-3-(2-chloro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydro-2l5-isoquinolin-2-yl)propyl acetate
- (R,E)-9-(3-(2-chloro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydro-2l5-isoquinolin-2-yl)propoxy)-9-oxonon-5-enoic acid
- Micuronium Chloride isomers
- Z-Micuronium Chloride
- Mivacurium Chloride Impurity 6
- Mivacurium Chloride Impurity 7
- Micuronium Chloride impurity
- Mivacurium dichloride
- Mivacurium chloride USP/EP/BP
- Mivacarium Chloride
- Mivacurium Chloride ( isomers)
- BMS-512148 (2S)-1
- Dapagliflozin ((2S)-1
- (S)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
- Micuronium chloride
- Lomiwa Reservoir
- (1R,1'R)-2,2'-((((E)-Oct-4-enedioyl)bis(oxy))bis(propane-3,1-diyl))bis(6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-ium) chloride
- Mivacurium chloride, nicotinic acetylcholine antagonist
- 106861-44-3
- 10686-44-3
- C58H80Cl2N2O14
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
- API
