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2'-Desoxyadenosin

2'-Deoxyadenosine  Struktur
958-09-8
CAS-Nr.
958-09-8
Bezeichnung:
2'-Desoxyadenosin
Englisch Name:
2'-Deoxyadenosine
Synonyma:
DA;DEOXYADENOSINE;IFN-α;(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol;2'-dA;-dA CEP;2'-dA·H2O;DESOXYADENOSINE;8-Bromo-2’8-Amino-2&rsquo
CBNumber:
CB7162318
Summenformel:
C10H13N5O3
Molgewicht:
251.24
MOL-Datei:
958-09-8.mol

2'-Desoxyadenosin Eigenschaften

Schmelzpunkt:
187-189 °C
Siedepunkt:
394.4°C (rough estimate)
Dichte
1.2938 (rough estimate)
Brechungsindex
1.7610 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand
powder
pka
pK1:3.8(+1) (25°C,μ=0.1)
Farbe
White
PH
3.8
Wasserl?slichkeit
Soluble in water and caustic soda.
maximale Wellenl?nge (λmax)
258 (pH 2);260 (pH 7)
Stabilit?t:
Hygroscopic
InChI
InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
InChIKey
OLXZPDWKRNYJJZ-RRKCRQDMSA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)C[C@@H]1O
CAS Datenbank
958-09-8(CAS DataBase Reference)
NIST chemische Informationen
Deoxyadenosine(958-09-8)
EPA chemische Informationen
Adenosine, 2'-deoxy- (958-09-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  2811
WGK Germany  3
RTECS-Nr. AU7358600
10-23
TSCA  Yes
HazardClass  6.1
PackingGroup 
HS Code  2934999090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

2'-Desoxyadenosin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

2'-Deoxyadenosine is a natural deoxyribonucleoside, which is a structural fragment of deoxyribonucleic acid DNA. It is a purine nucleoside component of DNA comprised of adenosine linked by its N9 nitrogen to the C1 carbon of deoxyribose. Like other natural nucleosides, it is involved in the transmission of genetic information in almost all biological cells, affecting protein synthesis and polysaccharide. It plays a very important role in regulating the growth, proliferation, differentiation and inhibition of cells in vivo.

Verwenden

2'-Deoxyadenosine is used in paradoxical stimulation study of human sperm motility. It plays an essential role as sperm motility stimulants used in sperm micro-injection on mouse and human embryo development. It finds an application in some cells as an energy source under energy stress conditions. It is involved in various biological processes to compare the functions of adenosine analogues.

Definition

ChEBI: 2'-deoxyadenosine is a purine 2'-deoxyribonucleoside having adenine as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside.

synthetische

2'-deoxyadenosine synthesis: esterification of adenosine, acylation of an acylating agent and an acid binding agent to obtain an acylate; the obtained acylate is then subjected to reduction and purification to obtain 2'-deoxyadenosine. The esterification agent used in the esterification process is dialkyl tin oxide, 2'-O-p-toluenesulfonyladenosine is synthesized from adenosine, and 2'-deoxyadenosine is synthesized from 2'-O-p-toluenesulfonyladenosine glycosides.

Biologische Aktivit?t

2'-Deoxyadenosine is a deoxyribonucleoside and an intermediate in the purine nucleotide degradation pathway. It is transported into cells via facilitated diffusion or formed within cells by degradation of S-adenosylhomocysteine or AMP and is removed from cells by purine metabolism or is converted into adenine nucleotides. 2'-Deoxyadenosine has been used in the characterization of DNA conformations and the synthesis of nucleoside analogs as antiviral agents.

Source

2'-Deoxyadenosine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). 2'-Deoxyadenosine is a natural product found in Streptomyces jiujiangensis, Fritillaria przewalskii, and other organisms with data available.

2'-Desoxyadenosin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2'-Desoxyadenosin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 415)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhu Nuowei chemistry Co., Ltd.
+86-0553-2911116-802 +undefined17756524438
sales1@nuowei-chem.com China 1638 58
Yunbio Tech Co.,Ltd.
+86-010-60605551 +86-18046518538
yunbiochem@126.com China 321 58
SHANGHAI NOVRIBO BIOTECH
17821030819
June.Liu@Desano.com China 73 58
Hangzhou Measure Life Technology Co., LTD
+8613343730176
2924244016@qq.com China 83 58
Allbiosyn Biotechnology Co.,Ltd.
+8618666985712
info@allbiosyn.com China 286 58
Xinxiang Aurora Biotechnology Co.,Ltd.
+86-0086-0373-3088722 +8618637352520
info@aurora-biotech.com China 93 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
HangZhou RunYan Pharma Technology Co.,LTD.
+8618882027439
sales2@runyanpharma.com China 302 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55

958-09-8(2'-Desoxyadenosin)Verwandte Suche:


  • (2R,3S,5R)-5-(6-AMINO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL
  • 2'-DEOXYADENOSINE
  • 2'-DEOXY-D-ADENOSINE
  • 2'-Deoxyadenosineanhydrous
  • 2'-dA·H2O
  • 2'-Deoxy-a-adenosine
  • 2’-deoxy-adenosin
  • 9-(2-Deoxy-beta-D-erythro-pentofuranosyl)adenine
  • 9H-Purin-6-amine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-
  • 9H-Purin-6-amine, 9-(2-deoxy-beta-D-ribofuranosyl)-
  • Adenine deoxy nucleoside
  • Adenine deoxyribonucleoside
  • 2''-DEOXYADENOSINE (isolated from DNA)
  • adeninedeoxyribonucleoside
  • adeninedeoxyribose
  • Adenosine, 2'-deoxy-
  • Adenyldeoxyriboside
  • beta-D-Erythro-Pentofuranoside, adenine-9 2-deoxy-
  • beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-
  • ADENINE DESOXYRIBOSIDE
  • DEOXYADENOSINE-2'
  • DESOXYADENOSINE
  • 9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)ADENINE
  • 2-Methoxy 2&rsquo
  • N6-Benzoyl-8-benzyloxy-2&rsquo
  • 3-Deaza-3-methyl-2&rsquo
  • -dA CEP
  • 2'-Deoxyadenosine(Da)
  • N6-(6-Aminohexyl)-2&rsquo
  • -deoxyadenosine-13C2,15N
  • 6-N-Acyl-6-N-methyl-2&rsquo
  • 8-Bromo-2&rsquo
  • N6-Benzoyl-8-oxo-2&rsquo
  • 8-Amino-2&rsquo
  • 2-Amino-N2-isobutyryl-2&rsquo
  • 2-Amino-5&rsquo
  • -O-(dimethoxytrityl)-N6-(dimethylaminomethylidene)-N2-isobutyryl-2&rsquo
  • 8-Bromo-N6-(dimethylaminomethylidene)-2&rsquo
  • N6-Benzoyl-5&rsquo
  • -O-(dimethoxytrityl)-8-oxo-2&rsquo
  • 2-Fluoro-2&rsquo
  • 8-Azido-2&rsquo
  • 7-(3-Nitrophenyl)-7-deaza-2&rsquo
  • 2'-Deoxyadenosine anhydrate
  • 2'-DeoxyadenosineAnhydrous>
  • 2'-Deoxyadenosine USP/EP/BP
  • 2'-Deoxyadenosine-WIDELY
  • (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
  • DA
  • DEOXYADENOSINE
  • IFN-α
  • 2'-Deoxyadenosine(2'-dA)
  • Rabbit Interferon Alpha (IFNa)ELISA Kit
  • Monkey Interferon Alpha (IFNa)ELISA Kit
  • 2'-Deoxyadenosine Anhydrous, ≥ 98.0%
  • 2'-Deoxyadenosine
  • 2'-Deoxyadenosine(2'-dA)
  • 2'-Deoxyadenosine Anhydrous
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