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Cobamamid

Coenzyme B12 Struktur
13870-90-1
CAS-Nr.
13870-90-1
Bezeichnung:
Cobamamid
Englisch Name:
Coenzyme B12
Synonyma:
COBAMAMIDE;adenosylcobalamin;dibencozide;COENZYME B12;lm176;AdoCbl;COBAMIDE;calomide;funacomide;enzyme B12
CBNumber:
CB8433734
Summenformel:
C72H99CoN18O17P
Molgewicht:
1578.6
MOL-Datei:
13870-90-1.mol

Cobamamid Eigenschaften

storage temp. 
-20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Aggregatzustand
Solid
pka
3.5(at 25℃)
Farbe
Red to Very Dark Red
Wasserl?slichkeit
26g/L(24 ºC)
Merck 
13,2476
BRN 
4122932
Stabilit?t:
Hygroscopic
InChIKey
WAJLPPDUWGAMTH-NGQUPMDYNA-L
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 22-24/25-36-26
WGK Germany  3
RTECS-Nr. GG3800000
8
HS Code  2936260000
Toxizit?t LD50 oral in guinea pig: 5gm/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Cobamamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Coenzyme B12 (adenosylcobalamin; AdoCbl; 5'-Deoxyadenosylcobalamin) is a form of vitamin B12. It belongs to the corrinoid group of compounds containing a corrin macrocycle and are produced only by certain bacteria and archaea. It is a cofactor for various enzymes, including mutases, eliminases, aminomutases, and reductases. These enzymes catalyze reactions that generate free radicals through the release of the adenosyl group, allowing usually unreactive molecules to become reactive. Genetic mutations in enzymes synthesizing Coenzyme B12 lead to Coenzyme B12 deficiency and methylmalonic aciduria.

Verwenden

emulsifying agent

Definition

ChEBI: A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.

Allgemeine Beschreibung

Vitamin B12 cobalamin refers to a group of chemically-related cobalt containing molecules. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms.

Landwirtschaftliche Anwendung

Cobamide enzyme is the cobalt complex formed between the cobalt-porphyrin ring structure and the nucleotide in vitamin B12 co-enzyme.

Einzelnachweise

[1] Thuan Phu Nguyen-Vo. “Analysis and characterization of coenzyme B12 biosynthetic gene clusters and improvement of B12 biosynthesis in Pseudomonas denitrificans ATCC 13867.” Fems Microbiology Letters 365 21 (2018).
[2] I. I. Merkelbach, Hm Henk Buck. “Mechanism of action of coenzyme B12. Quantum-chemical considerations.” Recueil des Travaux Chimiques des Pays-Bas 28 1 (2010): 166–169.
[3] Prof. Dr. Karl Gruber, Prof. Dr. Bernhard Krutler. “Coenzyme B12 Repurposed for Photoregulation of Gene Expression.” Angewandte Chemie International Edition 55 19 (2016): 5638–5640.

Cobamamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cobamamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 264)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Leading Chemical and Trading Co.,Ltd
+8615669938129
sales@leadingchemical.com China 130 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953
info@konochemical.com China 1169 58

13870-90-1(Cobamamid)Verwandte Suche:


  • DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-
  • DMBC COENZYME
  • COBAMAMIDE/DIBENCOZIDE
  • COBAMIDE
  • 5'-deoxyadenosylcobalamin
  • 5'-DEOXYADENOSYLCOBALAMINE
  • ADENOSYL COBALAMINE
  • 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME
  • ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz
  • coenzyme B12 crystalline
  • Cobamamide/VitaminB12
  • Coenzyme B12
  • ADENOSYLCOBALAMINE(COENZYME B12)(RG)
  • COBAMAMIDE (PYROGEN FREE)
  • 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
  • cobalaminecoenzyme
  • cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e
  • dbccoenzyme
  • deoxyadenosylcobalamin
  • funacomide
  • lm176
  • ADENOSYLCOBALAMINE(COENZYME B12)(P)
  • Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
  • ADENOSYLCOBALAMINE(COENZYME B12)(AS)
  • CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI)
  • COENZYME B12, >=97.0%
  • 5’-deoxyadenosylvitaminb12
  • calomide
  • Cobamamide (Dibencozide, Coenzyme B12)
  • Cyanocobalamin Impurity 14
  • AdoCbl
  • Cobamamide, DMBC coenzyme
  • Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate),inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3)
  • 5'-Deoxyadenosylcobalamin USP/EP/BP
  • COENZYME B12
  • COBAMAMIDE
  • dibencozide
  • adenosylcobalamin
  • (2S,3S,4R,5R)-2-(6-Aminopurin-9-yl)-5-methanidyloxolane-3,4-diol
  • enzyme B12
  • [(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] hydrogen phosphate
  • ADENOSYLCOBALAMINE(COENZYME B12)
  • Cobamamide (Active Vitamin B12)
  • Cobamamide|||Coenzyme B12|||AdoCbl
  • 5'-Deoxyadenosylcobalamin
  • Vitamin B12 Cobamamide
  • Cyanocobalamin Impurity K
  • 13870-90-1
  • C72Co1H100N18O17P1
  • C72H100CoN18O17P
  • Other Cofactors
  • Enzymes, Inhibitors, and Substrates
  • Cofactors
  • Biochemicals and Reagents
  • BioChemical
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • PHARMACEUTICALS
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