Dapoxetine hydrochloride
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- CAS-Nr.
- 129938-20-1
- Englisch Name:
- Dapoxetine hydrochloride
- Synonyma:
- DAPOXETINE HCL;Dapoxetin HCl;Priligy;DL-Dapoxteine HCL;Dapoxetine HCL (Priligy);LY-21044;LY-210448;Dapoxetine HCI;Rimonabant 75000;Dapoxetine HCL-IHS
- CBNumber:
- CB7104314
- Summenformel:
- C21H24ClNO
- Molgewicht:
- 341.88
- MOL-Datei:
- 129938-20-1.mol
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Dapoxetine hydrochloride Eigenschaften
- Schmelzpunkt:
- 175-1790C
- alpha
- D +135.78° (c = 2.18 in methanol)
- storage temp.
- room temp
- L?slichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- Farbe
- white
- Optische Aktivit?t
- [α]/D +125 to +135°, c = 1 in methanol
- Merck
- 14,2821
- InChI
- InChI=1/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/s3
- InChIKey
- IHWDIQRWYNMKFM-OZYVVJTJNA-N
- SMILES
- O(C1=CC=CC2C=CC=CC1=2)CC[C@@H](C1C=CC=CC=1)N(C)C.Cl |&1:13,r|
- CAS Datenbank
- 129938-20-1(CAS DataBase Reference)
Dapoxetine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Dapoxetine hydrochloride, belonging to the class of SSRIs, was the first drug originally approved for the on-demand treatment of men with PE by seven European countries in 2008.
Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine is a short-acting SSRI. It is differentiated from the existing SSRI treatments for PE by the fact that it can be administered on an as-needed basis. In healthy subjects, dapoxetine is rapidly absorbed after oral administration with a peak plasma concentration (Tmax) occurring between 1.4 and 2h.
Chemische Eigenschaften
Dapoxetine hydrochloride is a white to slightly yellow powder. It is freely soluble in methanol, propylene glycol, some organic solvents (eg. N,N-dimethylformamide) , slightly soluble in ethanol and almost insoluble in water. It is a BCSI class II compound, and poor solubility is a key factor affecting the difference in clinical efficacy. Dapoxetine hydrochloride exists in various crystal forms, the solubility of different crystal forms is quite different, and there is a phenomenon of phase and transformation between crystal forms.
Verwenden
Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men.
Allgemeine Beschreibung
Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.
Mode of action
The mechanism of action of dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre- and post-synaptic receptors. Dapoxetine is a centrally-acting SSRI that modulates serotonin levels in relevant areas such as the lateral paragigantocellular nucleus through inhibition of the serotonin transporter (SERT). This compound also decreases peak amplitude and accelerates the decay rate of current inactivation in a variety of voltage-gated K+ channels.
Dapoxetine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dapoxetine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 633)Lieferanten
129938-20-1()Verwandte Suche:
- Dapoxetine hydrochloride
(1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
- S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride
- Mixed spin Dapoxetine
- (1s)-n,n-dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
- Rimonabant 75000
- (aS)-N,N-Dimethyl-a-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
- LY-21044
- ((S)-(+)-N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride)
- (S)-(+)--N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine
- Dapoxetine hydrochloride
- (aS)-N,N-Dimethyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
- LY-210448
- Dapoxetine hcl for R&D
- naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
- (S)-Dapoxetine hydrochloride
- (αS)-N,N-DiMethyl-α-[2-(1-naphthalenyloxy)ethyl]benzeneMethanaMine
- Dapoxetine hydrochloride|S1869
- Dapoxetine hydrochloride(Priligy)
- N,N-DiMethyl-1-phenyl-3-(1-naphthalenyloxy)propanaMinehydrochloride
- (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride
- D-(+)N,N-diMethyl-3-(naphthalen-1-yloxy)
- (αS)- N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-benzenemethanamine, hydrochloride (1:1)
- (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidDapoxetine hydrochloride
- Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, hydrochloride, (S)-
- (S)-N,N-DIMETHYL-Α-[2-(1-NAPHTHALENY-LOXY)ETHYL]BENZENEMETHANAMINE HYDROCHLORIDE
- Dapoxetine hydrochloride, 98%, a short-acting novel selective serotonin reuptake inhibitor
- DapoxetineHydrochloride>
- Dapoxetine hydrochloride,>98%
- Dapoxetine Hydrochlorid Salt
- (S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropylamine Hydrochloride
- (S)-N,N-Dimethyl-alpha-[2-(1-naphthyloxy)ethyl]benzylamine Hydrochloride
- Dapoxetine hydrochloride USP/EP/BP
- Hydrochloride Dapoxetine
- Right-handed poxetine
- Dapoxetine HCI
- Dapoxetine HCL-IHS
- Dapoxetine HCl (LY-210448 HCl)
- Dapoxetine HydrochlorideQ: What is
Dapoxetine Hydrochloride Q: What is the CAS Number of
Dapoxetine Hydrochloride Q: What is the storage condition of
Dapoxetine Hydrochloride Q: What are the applications of
Dapoxetine Hydrochloride
- Dapoxetine/Dapoxetine HCl/Dapoxetine hydrochloride
- LY-210448 hydrochloride
- PRILIGY;LY-210448 HYDROCHLORIDE
- (S)-N,N-dimethyl-3-
- D-Dapoxetine Hydrochloride
- DAPOXETINE HCL
- Dapoxetin HCl
- Dapoxetine HCL (Priligy)
- DAPOXETINE HYDROCHLORIDE CHEMISTRY PURE 98.5% HPLC
- DL-Dapoxteine HCL
- Priligy
- Dapoxetine / Priligy
- Dapoxetine HCl Powder
- Dapoxetine Hydrochloride, ≥ 98.0%
- Dapoxetine hydrochloride
- LY-210448|||LY-210448 hydrochloride|||Dapoxetine HCl|||Priligy
- Dapoxetine Hydrochloride B
- Dapoxetine Hydrochloride C
- 129938-20-1
- 1299-20-1
