3,4-Diaminopyridin
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3,4-Diaminopyridin Eigenschaften
- Schmelzpunkt:
- 216-218 °C (lit.)
- Siedepunkt:
- 194.6°C (rough estimate)
- Dichte
- 1.1118 (rough estimate)
- Brechungsindex
- 1.5340 (estimate)
- Flammpunkt:
- 240 °C
- storage temp.
- Store below +30°C.
- L?slichkeit
- 30g/l
- pka
- 9.17±0.12(Predicted)
- Aggregatzustand
- Crystalline Powder
- Farbe
- Brownish to brown-gray
- Wasserl?slichkeit
- 24 g/L (20 ºC)
- Merck
- 14,2986
- BRN
- 110232
- InChI
- InChI=1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)
- InChIKey
- OYTKINVCDFNREN-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(N)=C1N
- CAS Datenbank
- 54-96-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T+,T,Xi | ||
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R-S?tze: | 25-26-36/37/38 | ||
S-S?tze: | 26-28-36/37/39-45-37/39-28A-36 | ||
RIDADR | UN 2811 6.1/PG 2 | ||
WGK Germany | 3 | ||
RTECS-Nr. | US7600000 | ||
F | 10-23 | ||
Selbstentzündungstemperatur | 480 °C | ||
Hazard Note | Irritant | ||
HazardClass | 6.1 | ||
PackingGroup | I | ||
HS Code | 29333999 | ||
Toxizit?t | LD50 orally in Rabbit: 47 mg/kg LD50 dermal Rabbit > 200 mg/kg |
Bildanzeige (GHS) |
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Alarmwort | Achtung | |||||||||||||||||||||
Gefahrenhinweise |
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Sicherheit |
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3,4-Diaminopyridin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.R26:Sehr giftig beim Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
brownish to brown-grey crystalline powderVerwenden
It is a potassium channel blocker in nerve terminals. It inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.Indications
3,4-diaminopyridine has been used to treat Lambert Eaton myasthenia (LEM) for thirty years despite the lack of conclusive evidence of efficacy.Lambert–Eaton myasthenic syndrome is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction, which result from impaired release of acetylcholine from cholinergic nerve terminals. It is frequently associated with cancer, it is autoimmune-mediated, and treatment has been unsatisfactory.
The drug 3,4-diaminopyridine (3,4-DAP) increases neurotransmitter release and also the action potential (by blocking potassium conductance); these actions lead to a nonspecific excitatory effect on the cholinergic system, and provide benefit. It should be taken orally, 4-5 times per day. Adverse effects due to CNS excitation (insomnia, seizures) can occur.
l?uterung methode
It crystallises from *benzene and is stored under N2 because it is deliquescent and absorbs CO2. [Beilstein 22/11 V 266.]3,4-Diaminopyridin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
FUMING SULFURIC ACID
Ammoniak, wssrige Lsung
Palladium
Pyridin-4-ol
4-Amino-3-nitropyridine
Pentachlorphosphoran
Salpetersure
Methanol
Ammoniumacetat
Downstream Produkte
3,4-Diaminopyridin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 432)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Jinan Dexinjia Bio&Tech Co., Ltd | +86-0531-82375818 +86-15064153060 |
sales@jndxj.com | China | 1267 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8805 | 58 |
Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12830 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20263 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +8613288715578 |
angelia@hbmojin.com | China | 1175 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29793 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21632 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
FandaChem@Gmail.com | China | 8753 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29871 | 58 |
54-96-6(3,4-Diaminopyridin)Verwandte Suche:
N,N-Dimethylpyridin-4-amin
Pyridin-2,6-diyldiamin
3-Pyridylamin
Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat
Iminodiacetonitril
2-Pyridylamin
2,5-Diaminopyridine
Pyridin-2,3-diyldiamin
PYRIDINE-2,4-DIAMINE
Pyridin-2,5-diamindihydrochlorid
4-Methylpyridin-2,6-diamin
3-(Phenylazo)-2,6-pyridindiamin-monohydrochlorid
3,4-Diaminopyridin
- 3,4-pyridinediamine
- Pyridine, 3,4-diamino-
- WLN: T6NJ CZ DZ
- 4,5-diaminopyridine
- diamino-3,4pyridine
- TIMTEC-BB SBB004341
- DIAMINOPYRIDINE(3,4-)
- ASINEX-REAG BAS 01447204
- 3-AMINO-4-PYRIDINYLAMINE
- 3,4-DIAMINOPYRIDINE
- 3,4-DIAMINOPYRIDINE 98+%
- 3,4-DIAMINE-PYRIDINE
- 3,4-Pyridinedramine
- NSC 521760
- pyridin-3,4-diaMine
- 3,4-DIAMINOPYRIDINE FOR SYNTHESIS
- Pyridine-4,5-diaMine
- 3,4- twoaMinopyridine
- (3-amino-4-pyridyl)amine
- 3,4-DAP
- 3,4-Pyridinediamine (9CI)
- 3,4-Diaminopyridine C5H7N3
- 3,4-Diaminopyridine >
- 3,4-Diaminopyridine, 98%, for synthesis
- 3,4-Diaminopyridine ISO 9001:2015 REACH
- TIANFU-CHEM - 3,4-Diaminopyridine
- 3,4-diamino-pyridin
- PYRIDINE-3,4-DIAMINE
- Amifampridine
- 3,4-Diamino[3,4-b]pyridine
- Fampridine Impurity 20
- Amipyridine
- Amifampridin, (3,4-Diaminopyridin)
- Amifampridine, 10 mM in DMSO
- 54-96-6
- Building Blocks
- C5
- Heterocyclic Building Blocks
- Pyridines
- Boronic Acid
- pyridine series
- Building Blocks
- C5
- Chemical Synthesis
- Heterocyclic Building Blocks
- Pyridine
- Pyridines, Pyrimidines, Purines and Pteredines
- Amines
- Pyridines
- bc0001