2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion
|
|
- CAS-Nr.
- 2222-07-3
- Bezeichnung:
- 2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion
- Englisch Name:
- CUCURBITACIN I
- Synonyma:
- JSI-124;Ibamarin;ELATERIN B;NSC 521777;ELATERICIN B;CUCURBITACIN I;5-tetrahydroxy-;cucurbitacine(i);Cucurbitacin I-RM;CUCURBITACIN I(SH)
- CBNumber:
- CB6480840
- Summenformel:
- C30H42O7
- Molgewicht:
- 514.65
- MOL-Datei:
- 2222-07-3.mol
|
2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Eigenschaften
- Schmelzpunkt:
- 148-150°C
- Siedepunkt:
- 698.3±55.0 °C(Predicted)
- Dichte
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- ≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
- pka
- 8.51±0.70(Predicted)
- Aggregatzustand
- solid
- Farbe
- white to off-white
- LogP
- 2.330 (est)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher |
Xi,T+ |
|
|
R-S?tze: |
25-28 |
|
|
S-S?tze: |
1-22-45-36/37-28 |
|
|
RIDADR |
UN 2811 6.1/PG 1 |
|
|
WGK Germany |
3 |
|
|
RTECS-Nr. |
RC6200000 |
|
|
Toxizit?t |
LD50 oral in mouse: 5mg/kg |
|
|
Bildanzeige (GHS) |
|
Alarmwort |
Achtung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
|
Sicherheit |
|
2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R28:Sehr giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S1:Unter Verschluss aufbewahren.
S22:Staub nicht einatmen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
Definition
ChEBI: Cucurbitacin I is a cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. It has a role as a plant metabolite and an antineoplastic agent. It is a cucurbitacin and a tertiary alpha-hydroxy ketone.
Biologische Aktivit?t
Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
Biochem/physiol Actions
Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.
2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 117)Lieferanten
2222-07-3(2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion)Verwandte Suche:
2,16α,20,25-Tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-trien-3,11,22-trion-25-acetat
2-Allylcyclohexan-1-on
Cyclohexan-1,2-dion
p-Menthan-3-on
2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion
2,6,8-Trimethylnonan-4-on
2,6,10-Trimethylundec-9-enal
6,10,14-Trimethylpentadecan-2-on
2-Hydroxyadipaldehyd
2,6-Dimethylhept-5-enal
1-(Cyclohexenyl)aceton
Dodec-3-en-1-al
2,7-Dimethyloct-5-en-4-on
- ELATERICIN B
- ELATERIN B
- CUCURBITACIN I WITH HPLC
- Cucurbitacin I hydrate
- Elatericin B, JSI-124, NSC 521777, 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
- (9β,10α,23E)-2,16α,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
- Ibamarin
- 2,16a,20,25-Tetrahydroxy-9b-methyl-10a-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
- 2,16α,20,25-tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
- 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9b,10a,16a,23E)-
- CUCURBITACIN I(SH)
- CUCURBITACIN I hplc
- (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
- 2,16α,20,25-tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
- NSC 521777
- Cucurbitacin I (JSI-124)
- calebassine/cucurbitacin
- CUCURBITACIN I
- 1,2-dehydroelatericina
- 19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,9-methyl-2,16,20,2
- JSI-124
- 2,16alpha,20,25-tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
- 5-tetrahydroxy-
- cucurbitacine(i)
- Cucurbitacin I (Elatericin B
- 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9β,10α,16α,23E)-
- Cucurbitacin I-RM
- Cucurbitacin I(AS)
- 2222-07-3
- 2222-7-3
- Inhibitor
- Herb extract
- API
- Tri-Terpenoids