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2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion

CUCURBITACIN I Struktur
2222-07-3
CAS-Nr.
2222-07-3
Bezeichnung:
2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion
Englisch Name:
CUCURBITACIN I
Synonyma:
JSI-124;Ibamarin;ELATERIN B;NSC 521777;ELATERICIN B;CUCURBITACIN I;5-tetrahydroxy-;cucurbitacine(i);Cucurbitacin I-RM;CUCURBITACIN I(SH)
CBNumber:
CB6480840
Summenformel:
C30H42O7
Molgewicht:
514.65
MOL-Datei:
2222-07-3.mol

2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Eigenschaften

Schmelzpunkt:
148-150°C
Siedepunkt:
698.3±55.0 °C(Predicted)
Dichte
1.26±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
pka
8.51±0.70(Predicted)
Aggregatzustand
solid
Farbe
white to off-white
LogP
2.330 (est)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,T+
R-S?tze: 25-28
S-S?tze: 1-22-45-36/37-28
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS-Nr. RC6200000
Toxizit?t LD50 oral in mouse: 5mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit

2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R28:Sehr giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S1:Unter Verschluss aufbewahren.
S22:Staub nicht einatmen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).

Definition

ChEBI: Cucurbitacin I is a cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. It has a role as a plant metabolite and an antineoplastic agent. It is a cucurbitacin and a tertiary alpha-hydroxy ketone.

Biologische Aktivit?t

Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Biochem/physiol Actions

Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.

2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 118)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd. 		18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897
 sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Shaanxi Pioneer Biotech Co., Ltd . 		+8613259417953
 sales@pioneerbiotech.com China 3000 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Aktin Chemicals, Inc. 		028-85159085
info@aktinchem.com CHINA 1025 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38460 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52925 58

2222-07-3(2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion)Verwandte Suche:

  • ELATERICIN B
  • ELATERIN B
  • CUCURBITACIN I WITH HPLC
  • Cucurbitacin I hydrate
  • Elatericin B, JSI-124, NSC 521777, 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
  • (9β,10α,23E)-2,16α,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
  • Ibamarin
  • 2,16a,20,25-Tetrahydroxy-9b-methyl-10a-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
  • 2,16α,20,25-tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
  • 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9b,10a,16a,23E)-
  • CUCURBITACIN I(SH)
  • CUCURBITACIN I hplc
  • (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
  • 2,16α,20,25-tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
  • NSC 521777
  • Cucurbitacin I (JSI-124)
  • calebassine/cucurbitacin
  • CUCURBITACIN I
  • 1,2-dehydroelatericina
  • 19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,9-methyl-2,16,20,2
  • JSI-124
  • 2,16alpha,20,25-tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
  • 5-tetrahydroxy-
  • cucurbitacine(i)
  • Cucurbitacin I (Elatericin B
  • 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9β,10α,16α,23E)-
  • Cucurbitacin I-RM
  • Cucurbitacin I(AS)
  • 2222-07-3
  • 2222-7-3
  • Inhibitor
  • Herb extract
  • API
  • Tri-Terpenoids
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