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Pimobendan

Pimobendan Struktur
74150-27-9
CAS-Nr.
74150-27-9
Englisch Name:
Pimobendan
Synonyma:
VetMedin;(5RS)-6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5- methyl-4,5-dihydropyridazin-3(2H)-one;Acardi;UD-CG 115;PIMOBENDAN;Pimobendam;Pimobendane;UD-CG 115BS;Pimobendanum;PiMobendan EP
CBNumber:
CB6472876
Summenformel:
C19H18N4O2
Molgewicht:
334.37
MOL-Datei:
74150-27-9.mol

Pimobendan Eigenschaften

Schmelzpunkt:
approximate 243℃ (dec.)
Dichte
1.36
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble5mg/mL, clear (warmed)
Aggregatzustand
powder
pka
10.55±0.10(Predicted)
Farbe
white to beige
InChI
InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
InChIKey
GLBJJMFZWDBELO-UHFFFAOYSA-N
SMILES
C1(=O)NN=C(C2C=C3NC(C4=CC=C(OC)C=C4)=NC3=CC=2)C(C)C1
CAS Datenbank
74150-27-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  UN 2811 6.1 / PGIII
HS Code  2933995300
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit

Pimobendan Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pimobendan, a novel cardiotonic vasodilator, was introduced in Japan for the treatment of acute and mild to moderate chronic heart failure. It is a phosphodiesterase Ⅲ inhibitor and is able to enhance sensitization of myocardial contractile regulatory protein to calcium ions. The combination of these effects contribute to its inotropic activity. In patients with severe congestive heart failure, orally administered pimobendan improves cardiac index, stroke volume index, pulmonary wedge pressure, and systemic and pulmonary vascular resistance. Pimobendan is reported to be well tolerated and largely devoid of the proarrhythmic effects of classical phosphodiesterase Ill inhibitors. Studies also suggested that combination of the inotropic agent pimobendan with an ACE inhibitor such as enalapril may be superior to monotherapy for heart failure patients.

Chemische Eigenschaften

White Solid

Verwenden

Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.

Definition

ChEBI: Pimobendan is a pyridazinone and a member of benzimidazoles. It has a role as a cardiotonic drug, a vasodilator agent and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

Biologische Aktivit?t

Pimobendan is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 0.32 μM for guinea pig cardiac enzyme) that is selective for PDE3 over PDE1, PDE2, and PDE4 (IC50s = >30 μM). It is also a calcium sensitizer, decreasing the concentration of calcium required for half-maximal contractile force in isolated, skinned porcine ventricular fibers. Pimobendan increases the force of contraction in electrically-stimulated isolated guinea pig papillary muscles with an EC50 value of 6 μM, indicating positive inotropic effects. It increases survival time in dogs with congestive heart failure due to myxomatous mitral valve disease when administered in combination with angiotensin-converting enzyme inhibitors and furosemide . Formulations containing pimobendan have been used in the treatment of heart failure in dogs.

Mechanism of action

The mechanism of mild mitral regurgitation (MR) in dogs treated with Pimobendan is a dual mechanism of action, which enhances myocardial contractility by increasing calcium sensitisation of troponin C and promotes vasodilatation by inhibiting PDEIII.

Nebenwirkungen

The most common side effects include gastrointestinal effects such as decreased appetite, and diarrhea. Other possible side effects include lethargy and difficulty breathing This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.

Pimobendan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pimobendan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 314)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hpets Biotech Company (Chongqing) Co.,ltd
+8613340353813
info@hanpets.com China 26 58
Liaoning Pharmaceutical Innovation Co., Ltd
+8616588669988
sales@pipharma.com.cn China 151 58
Taizhou Creating Bio-pharm co., ltd.
+8613586099526
post@creatingbiopharm.com China 217 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
S&Y Biochem Co.,Ltd
+8617774091612
marketing@sybiochem.com China 126 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12825 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20288 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
sales@frappschem.com China 880 50
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55

  • 4,5-dihydro-6-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-5-methyl-3(2h)-pyridazinone
  • 6-(2-(4-methoxyphenyl)-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
  • 6-(2-(4-Methoxyphenyl)-4,5-dihydro-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone
  • Pimobendan [inn-spanish]
  • Pimobendane
  • Pimobendane [inn-french]
  • Pimobendanum
  • PiMobendan(VetMedin)
  • 4,5-Dihydro-6-[2-(4-Methoxyphenyl)-1H-benziMidazol-6-yl]-5-Methyl- 3(2H)-pyridazinone
  • Acardi
  • rac PiMobendan
  • PiMobendan EP
  • 6-[2-(4-Methoxy-phenyl)-1H-benzoiMidazol-5-yl]-5-Methyl-4,5-dihydro-2H-pyridazin-3-one
  • 6-(2-(4-Methoxyphenyl)-1H-benzo[d]iMidazol-5-yl)-5-Methyl-4,5-dihydropyridazin-3(2H)-one
  • PIMOBENDAN
  • 3(2H)-Pyridazinone,4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-
  • 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-y1]-5-methyl-3(2H)-pyridazinone
  • PIMOBENDANE HCL
  • Pimobendam
  • 3(2H)-Pyridazinone, 4,5-dihydro-6-2-(4-methoxyphenyl)-1H-benzimidazol-5-yl-5-methyl-
  • 3(2H)-Pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- (9CI)
  • dl-Pimobendan
  • Racemic pimobendan
  • UD-CG 115
  • UD-CG 115BS
  • VETMEDIN; ACARDI; PIMOBENDANE
  • 2-(2-Methyl-1-oxopropyl)isoindole-1,3-dione
  • Pimobendan CRS
  • Pimobendan for system suitability CRS
  • 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
  • Pimobendan USP/EP/BP
  • Pimobendan 13CD3Q: What is Pimobendan 13CD3 Q: What is the CAS Number of Pimobendan 13CD3
  • Pimobendan D3Q: What is Pimobendan D3 Q: What is the CAS Number of Pimobendan D3
  • Pimobendan-D4
  • Pimobendan (1569315)
  • (5RS)-6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5- methyl-4,5-dihydropyridazin-3(2H)-one
  • VetMedin
  • Pimobendan/UD-CG115
  • Acardi|||Pimobendane|||UD-CG 115 BS|||UD-CG115
  • Pimobendan in Acetonitrile
  • 74150-27-9
  • 7415-27-9
  • C19H18N4O2
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitor
  • Acardi, pimobendane
  • API
  • 74150-27-9
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