Methylisothiocyanat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R23/25:Giftig beim Einatmen und Verschlucken.
R34:Verursacht Ver?tzungen.
R43:Sensibilisierung durch Hautkontakt m?glich.
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S38:Bei unzureichender Belüftung Atemschutzger?t anlegen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Methyl iso thio cyanate is the organo sulfur compound with the formula CH
3N = C = S . This low melting colorless solid is a powerful lachrymator. As a precursor to a variety of valuable bioactive compounds, it is the most important organic iso thio cyanate in industry.
Chemische Eigenschaften
Methyl isothiocyanate is a crystalline solid.
Horseradish, acrid odor.
Occurrence
Reported found in horseradish.
Verwenden
Usually used to study the effect of pesticide Metam (methyl isothiocyanate is its active ingredient) in the streamside microbial communities of the upper Sacramento river
Definition
ChEBI: An isothiocyanate having a methyl group attached to the nitrogen.
Application
Solutions of MITC are used in agriculture as soil fumigants, mainly for protection against fungi and nematodes.
MITC is a building block for the synthesis of 1,3,4 - thiadiazoles, which are heterocyclic compounds used as herbicides. Commercial products include "Spike", "Ustilan," and "Erbotan." Well known pharmaceuticals prepared using MITC include Zantac and Tagamet.
Reaktionen
A characteristic reaction is with amines to give methyl thioureas:
CH
3NCS + R
2NH → R
2NC(S)NHCH
3 Other nucleophiles add similarly.
Allgemeine Beschreibung
A colorless liquid with a sharp odor. Lethal by inhalation of even small quantities of vapor. Does not have odor warning characteristics at low concentrations. Do not rely on the sense of smell to warn about the presence of vapors. Denser than water. Flash point below 20°F. May cause tearing and irritate the eyes, skin, nose and throat.
Air & Water Reaktionen
Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases.
Reaktivit?t anzeigen
Isocyanates and thioisocyanates, such as Methyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.
Hazard
Toxic by ingestion, strong irritant to eyesand skin.
Health Hazard
Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg.
Brandgefahr
(Non-Specific -- Pesticide, Solid, n.o.s.) Methyl isothiocyanate may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated Methyl isothiocyanate emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks.
Sicherheit(Safety)
MITC is a dangerous lachrymator as well as being poisonous.
m?gliche Exposition
It is used as a soil fumigant. A mixture of methyl isothiocyanate and chlorinated C-3 hydrocarbons is used as a soil fumigant for control of weeds, fungi,
insects, and nematodes.
Environmental Fate
Soil. Though no products were reported, the reported half-life in soil is <14 days
(Worthing and Hance, 1991).
Chemical/Physical. Emits toxic fumes of nitrogen and sulfur oxides when heated to
decomposition (Sax and Lewis, 1987).
Stoffwechselwegen
Methyl isothiocyanate is slowly decomposed in pure water, forming
methylamine. It is metabolised in rats to the mercapturate via the glutathione
conjugate which serves as a potential source of methyl isothiocyanate.
Methyl isothiocyanate is reactive with cellular thiols and amines
and its toxicity is associated with these reactions.
Versand/Shipping
UN2477 Methyl isothiocyanate, Hazard class:
6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable
liquid, Inhalation Hazard Zone B.
Inkompatibilit?ten
Dust may form explosive mixture with
air. Reacts with water, releasing carbon dioxide and
methylamine gases. Unstable and reactive; sensitive to oxygen and to light. Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, alcohols, strong bases,
amines, water, heat and cold. Attacks iron, zinc and other
metals
Waste disposal
In accordance with 40CFR
165 recommendations for the disposal of pesticides and
pesticide containers. Must be disposed properly by following package label directions or by contacting your local or
federal environmental control agency, or by contacting
your regional EPA office
Methylisothiocyanat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte