21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
|
|
|
- CAS-Nr.
- 25122-46-7
- Bezeichnung:
- 21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
- Englisch Name:
- Clobetasol propionate
- Synonyma:
- CLOBETASOLE PROPIONATE;Olux;Clobex;Temovate;CLOBETASOL-17-PROPIONATE;Psorex;Olux-E;cgp9555;GR-2/92;Karison
- CBNumber:
- CB6274337
- Summenformel:
- C25H32ClFO5
- Molgewicht:
- 466.97
- MOL-Datei:
- 25122-46-7.mol
|
21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Eigenschaften
- Schmelzpunkt:
- 195.5-1970C
- alpha
- D +103.8° (c = 1.04 in dioxane)
- Siedepunkt:
- 569.0±50.0 °C(Predicted)
- Dichte
- 1.1653 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
- pka
- 12.88±0.70(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- InChIKey
- CBGUOGMQLZIXBE-XGQKBEPLSA-N
- SMILES
- O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,16,18,20,23,r|
- CAS Datenbank
- 25122-46-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H373 |
Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 2 |
Warnung |
|
P260, P314, P501 |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
|
|
|
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
|
21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Topical corticosteroid. Glucocorticoid; anti-inflammatory.
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.
Indications
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most
potent of the currently available agents and is indicated for short-term treatment of
inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid.
It may cause a more rapid or prolonged response than other topical corticosteroids.
It is recommended that clobetasol have a maximum application of 60 g/week for
no longer than 14 days without occlusion and that it should not be used in children
below age 12.
Definition
ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 762)Lieferanten
25122-46-7(21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat)Verwandte Suche:
- 17-propionate
- cgp9555
- Clobetasol 17- propionate solution,100ppm
- Cloβsol propionate
- 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate
- CLOBETASOL 17-PROPIONATE USP
- [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
- Dermovate
- GR-2/92
- Psorex
- CLOBETASOLPROPIONATE,MICRONIZED
- CLOBETASOLPROPIONATE,MICRONIZED,USP
- 21-Chloro-21-deoxybetamethasone 17-propionate
- CCl 4725
- Clobederm
- Dermoval
- Dermoxinale
- GR 2/925
- Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
- Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate (8CI)
- 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione=17-propionate
- 21-Chloro-9α-fluoro-11β-hydroxy-16β-methyl-17α-propionyloxy-1,4-pregnadiene-3,20-dione
- Propionic acid clobetasol
- Clobetasol Propionate (200 mg)
- clobesol
- pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-me
- CLOBESTASOL PROPIONATE
- CLOBETASOL PROPIONATE
- 21-chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
- Pregna-1,4-Diene-3,20-Dione,21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-,(11Beta,16Beta)-
- Clobetasolpropionatmikron.
- 21-Chloro-9-fluoro-11b
- Clobetasol Propionate (200 mg)F2C309980ug/mg(ai)
- Clobetasol Propionate-d5
- 21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate
- Karison
- Olux-E
- Skin Cap
- (11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
- 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-d
- propanoic acid [(9R,17R)-17-(2-chloro-1-oxoethyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
- Clobetasol Propionate 25122-46-7
- Skin Disease Corticosteroids Raw Powder Clobetasol Propionate 25122-46-7
- Clobetasol propionate CRS
- Clobetasol Propionate RS
- Cloβsol17-Propionate>
- Clobetasol for peak identification CRS
- obetasoL
- 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-Methylpregn-4-ene-3,20-dione 17-Propionate
- Clobetasol-[d5] 17-propionate
- Clobetasol propionate USP/EP/BP
- Clobetazole propionate
- Clobetasol propionate (Y0000559)Q: What is
Clobetasol propionate (Y0000559) Q: What is the CAS Number of
Clobetasol propionate (Y0000559)
- Clobetasol for peak identification (Y0000570)
- Clobetasol PropionateQ: What is
Clobetasol Propionate Q: What is the CAS Number of
Clobetasol Propionate Q: What is the storage condition of
Clobetasol Propionate Q: What are the applications of
Clobetasol Propionate
- Cloβsol 17-propionate D3
- Clobetasol Propionate (1138405)
- Olux
