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21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat

Clobetasol propionate Struktur
25122-46-7
CAS-Nr.
25122-46-7
Bezeichnung:
21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
Englisch Name:
Clobetasol propionate
Synonyma:
CLOBETASOLE PROPIONATE;Olux;Clobex;Temovate;CLOBETASOL-17-PROPIONATE;Psorex;Olux-E;cgp9555;GR-2/92;Karison
CBNumber:
CB6274337
Summenformel:
C25H32ClFO5
Molgewicht:
466.97
MOL-Datei:
25122-46-7.mol

21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Eigenschaften

Schmelzpunkt:
195.5-1970C
alpha 
D +103.8° (c = 1.04 in dioxane)
Siedepunkt:
569.0±50.0 °C(Predicted)
Dichte
1.1653 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
L?slichkeit
Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
pka
12.88±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
CBGUOGMQLZIXBE-XGQKBEPLSA-N
SMILES
O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS Datenbank
25122-46-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,T
R-S?tze: 36/37/38-62-53-48/20/21-61
S-S?tze: 26-36-45-36/37-53
WGK Germany  2
RTECS-Nr. TU3725000
HS Code  29372290
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P273 Freisetzung in die Umwelt vermeiden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White or almost white, crystalline powder.

Verwenden

Topical corticosteroid. Glucocorticoid; anti-inflammatory.
Clobetasol Propionate
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Indications

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Definition

ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.

21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 762)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050
sean.lv@synzest.com China 323 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8816 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20288 58
Sigma Audley
+86-15937194204 +86-18126314766
nova@sh-teruiop.com China 493 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58

25122-46-7(21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat)Verwandte Suche:


  • 17-propionate
  • cgp9555
  • Clobetasol 17- propionate solution,100ppm
  • Cloβsol propionate
  • 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate
  • CLOBETASOL 17-PROPIONATE USP
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
  • Dermovate
  • GR-2/92
  • Psorex
  • CLOBETASOLPROPIONATE,MICRONIZED
  • CLOBETASOLPROPIONATE,MICRONIZED,USP
  • 21-Chloro-21-deoxybetamethasone 17-propionate
  • CCl 4725
  • Clobederm
  • Dermoval
  • Dermoxinale
  • GR 2/925
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate (8CI)
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione=17-propionate
  • 21-Chloro-9α-fluoro-11β-hydroxy-16β-methyl-17α-propionyloxy-1,4-pregnadiene-3,20-dione
  • Propionic acid clobetasol
  • Clobetasol Propionate (200 mg)
  • clobesol
  • pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-me
  • CLOBESTASOL PROPIONATE
  • CLOBETASOL PROPIONATE
  • 21-chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • Pregna-1,4-Diene-3,20-Dione,21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-,(11Beta,16Beta)-
  • Clobetasolpropionatmikron.
  • 21-Chloro-9-fluoro-11b
  • Clobetasol Propionate (200 mg)F2C309980ug/mg(ai)
  • Clobetasol Propionate-d5
  • 21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate
  • Karison
  • Olux-E
  • Skin Cap
  • (11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
  • 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-d
  • propanoic acid [(9R,17R)-17-(2-chloro-1-oxoethyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • Clobetasol Propionate 25122-46-7
  • Skin Disease Corticosteroids Raw Powder Clobetasol Propionate 25122-46-7
  • Clobetasol propionate CRS
  • Clobetasol Propionate RS
  • Cloβsol17-Propionate>
  • Clobetasol for peak identification CRS
  • obetasoL
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-Methylpregn-4-ene-3,20-dione 17-Propionate
  • Clobetasol-[d5] 17-propionate
  • Clobetasol propionate USP/EP/BP
  • Clobetazole propionate
  • Clobetasol propionate (Y0000559)Q: What is Clobetasol propionate (Y0000559) Q: What is the CAS Number of Clobetasol propionate (Y0000559)
  • Clobetasol for peak identification (Y0000570)
  • Clobetasol PropionateQ: What is Clobetasol Propionate Q: What is the CAS Number of Clobetasol Propionate Q: What is the storage condition of Clobetasol Propionate Q: What are the applications of Clobetasol Propionate
  • Cloβsol 17-propionate D3
  • Clobetasol Propionate (1138405)
  • Olux
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