Foscarnet Chemische Eigenschaften,Einsatz,Produktion Methoden
Definition
ChEBI: Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to bl
ndness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Enzyminhibitor
This pyrophosphate analogue (FWtrisodium salt = 191.95 g/mol; CAS 4428-95-
9), also called foscarnet, exhibits antiherpetic activity. It is a stro+ng inhibitor
of viral reverse transcriptases and viral replication as well as Na/phosphate
cotransporters. Target (s) : adenylyl cyclase; avian myeloblastosis virus
reverse transcriptase; cytomegalovirus DNA polymerase (4-6); DNA-
directed DNA polymerase; DNA polymerase b; DNA
polymerases, viral; duck hepatitis B virus reverse transcriptase
; Epstein-Barr virus DNA polymerase; equine infectious
anemia virus reverse transcriptase; exoribonuclease H; feline
immunodeficiency virus reverse transcriptase; geranyl-diphosphate
cyclase, or bornyl-diphosphate synthase; guanylyl cyclase; HIV-1
reverse transcriptase; human T-lymphotropic
virus type III reverse transcriptase; herpes virus reverse transcriptase
; human hepatitis B virus reverse transcripta+se;
Moloney murine leukemia virus reverse transcriptase; Na-dependent
phosphate transport (32-38); phosphoenolpyruvate carboxylase;
phosphoenolpyruvate mutase; phosphonoacetate hydrolase;
phosphonopyruvate hydrolase; ribonuclease H; RNA-directed
DNA polymerase; simian immunodeficiency virus
reverse transcriptase; and woodchuck hepatitis virus reverse
transcriptase.
Foscarnet Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
