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Cinmetacin

cinmetacin  Struktur
20168-99-4
CAS-Nr.
20168-99-4
Bezeichnung:
Cinmetacin
Englisch Name:
cinmetacin
Synonyma:
Cindomet;Indolacin;cinmetacin;cinmethacin;cinmetacin USP/EP/BP;5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid;1-(1-Oxo-3-phenyl-2-propenyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid;1H-Indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
CBNumber:
CB5899153
Summenformel:
C21H19NO4
Molgewicht:
349.38
MOL-Datei:
20168-99-4.mol

Cinmetacin Eigenschaften

Schmelzpunkt:
170-172°; mp 164-165°
Siedepunkt:
483.57°C (rough estimate)
Dichte
1.2520 (rough estimate)
Brechungsindex
1.5614 (estimate)
pka
4.00±0.30(Predicted)
Wasserl?slichkeit
<1mg/L(25 ºC)

Sicherheit

Toxizit?t LD50 in mice, rats (mg/kg): 360, 590 i.p.; 750, 1020 orally (Komatsu)

Cinmetacin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Cindomet,Chiesi

Manufacturing Process

6.0 g of cinnamoyl chloride was dropwise added to a mixture of 8.7 g of pmethoxyphenylhydrazine hydrochloride, 10.1 g of triethylamine and 200 ml of toluene under cooling at -5° to 0°C. The reaction mixture was stirred at 20°- 25°C for 1 h. The separated precipitates were filtered off and dry gaseous hydrogen chloride was introduced into the filtrate. As a result a large amount of crystals of N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride were produced. These crystals were collected by filtration and washed with 20 ml of ether and dried to yield N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride of melting point 183°-185°C.
A mixture of N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride and
acetonylmalonic acid was heated in acetic acid at heating with stirring. Thereafter, the reaction mixture was allowed to cool, and was poured into cold water, and then crystals were produced. They were collected by filtration, and dried to give crude product. The recrystallization from acetone-water gave fine white needle crystals of 1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid, melting point 164°-165°C.

Therapeutic Function

Antiinflammatory

Cinmetacin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cinmetacin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 7)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22787 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
PT CHEM GROUP LIMITED
+86-85511178; +86-85511178;
peter68@ptchemgroup.com China 35425 58

20168-99-4(Cinmetacin)Verwandte Suche:


  • cinmetacin
  • Indolacin
  • cinmethacin
  • 1-(1-Oxo-3-phenyl-2-propenyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
  • 5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid
  • Cindomet
  • 1H-Indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
  • cinmetacin USP/EP/BP
  • 20168-99-4
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