Methylmalonsaeure
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- CAS-Nr.
- 516-05-2
- Bezeichnung:
- Methylmalonsaeure
- Englisch Name:
- 2-Methylpropanedioic acid
- Synonyma:
- METHYLMALONIC ACID;2-Methylmalonic acid;AI315327;NSC 25201;onic acid;AI3 15327;AI3-15327;Methylmalonic;isosuccinicacid;Isosuccinic acid
- CBNumber:
- CB5713714
- Summenformel:
- C4H6O4
- Molgewicht:
- 118.09
- MOL-Datei:
- 516-05-2.mol
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Methylmalonsaeure Eigenschaften
- Schmelzpunkt:
- 128-130 °C (lit.)
- Siedepunkt:
- 272.71°C (rough estimate)
- Dichte
- 1.45
- Brechungsindex
- 1.4304 (estimate)
- Flammpunkt:
- 2℃
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Crystalline Powder
- pka
- 3.07, 5.76(at 25℃)
- Farbe
- White
- Wichte
- 1.455
- PH
- 3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution)
- Wasserl?slichkeit
- soluble
- BRN
- 1756084
- CAS Datenbank
- 516-05-2(CAS DataBase Reference)
- NIST chemische Informationen
- Methylmalonic acid(516-05-2)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Methylmalonsaeure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white crystalline powder
Verwenden
2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
Definition
ChEBI:
Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).
Biologische Funktion
Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
Allgemeine Beschreibung
Methylmalonic acid is an indicator of vitamin B
12 deficiency and methylmalonic acidemia. This Certified Spiking Solution
? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
l?uterung methode
The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]
Methylmalonsaeure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-p-Cumenyl-2-methylpropionaldehyd
5-hydroxy-3-Methyl-2(5H)-furanone
2-Propenoic acid, 3-(2,6-dichlorophenyl)-2-methyl-
Benzenepropanoic acid, β-amino-α-methyl-, (αR,βS)-rel-
2H-Pyrano[3,2-c]pyridine-2,5(6H)-dione, 4-hydroxy-3,6,7-trimethyl- (9CI)
Methylmalonsaeure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 306)Lieferanten
516-05-2(Methylmalonsaeure)Verwandte Suche:
Diethylmethylmalonat
1,3-Difluor-4-nitrobenzol
1-(2-Fluor[1,1'-biphenyl]-4-yl)ethan-1-on
2,4-Difluor-1,1'-biphenyl
Diethyl-(3-fluor-4-nitrophenyl)methylmalonat
Diethyl-(4-amino-3-fluorphenyl)methylmalonat
2,4-Difluoranilin
Flurbiprofen
4-Brom-2-fluor-1,1'-biphenyl
Ethyl-2-chlorpropionat
Diethyl-(2-cyanethyl)malonat
Ethylmalonsure
Diethylbis(hydroxymethyl)malonat
Dimethyldiethylmalonat
Tetraethylethan-1,1,2,2-tetracarboxylat
2,2,5-Trimethyl-1,3-dioxan-4,6-dion
Diethylallylmalonat
Triethylmethantricarboxylat
- 1,1-Ethanedicarboxylic acid
- 1,1-ethanedicarboxylicacid
- 2-methylmalonicacid
- Isosuccinic acid
- isosuccinicacid
- Malonic acid, methyl-
- methyl-malonicaci
- Methylmalonic acid,96%
- Methylmalonic acid,2-Methylpropanedioic acid
- Methyl (Ethoxy Methylene) Cyanoacetate
- Methylmalonicacid,98%
- Methylmalonic
- MethylMalonic acid, 96% 5GR
- NSC 25201
- Methylmalonic acid solution
- METHYLPROPANEDIOIC ACID
- 2-METHYLPROPANEDIOIC ACID
- PROPANEDIOIC ACID, METHYL-
- onic acid
- MethylmalonicAcid>
- Propanedioic acid, 2-methyl-
- Flurbiprofen Impurity 28
- 516-05-2 2-Methylpropanedioic acid C4H6O4
- AI3 15327
- AI315327
- AI3-15327
- METHYLMALONIC ACID
- 2-Methylmalonic acid
- NSC 25201|||MMA|||Isosuccinic acid|||Methylpropanedioic acid|||Methylmalonate
- Methylmalonic acid in methanol
- Methylmalonic Acid in Acetonitrile
- Methyl Malonic Acid / 2-Methylpropanedioc acid
- 516-05-2
- HOOCCHCH3COOH
- CH3CHCO2H2
- Carboxylic Acids
- Carbonyl Compounds
- C1 to C5
- Building Blocks
- Organic Building Blocks
- Building Blocks
- C1 to C5
- Carbonyl Compounds
- Carboxylic Acids
- Chemical Synthesis
- Organic Building Blocks
- Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
- API intermediates
- Aliphatics
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
