TYRPHOSTIN B46
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- CAS-Nr.
- 133550-34-2
- Englisch Name:
- TYRPHOSTIN B46
- Synonyma:
- AG 555;AG 555, >98%;TYRPHOSTIN B46;TYRPHOSTIN AG 555;TyrphostinB46 AG 555;TyrphostinB46 A 555;AG555（Tyrphostin B46）;TYRPHOSTIN AG 555, >98%;AG 555 (Tyrphostin AG 555);TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555
- CBNumber:
- CB5469835
- Summenformel:
- C19H18N2O3
- Molgewicht:
- 322.36
- MOL-Datei:
- 133550-34-2.mol
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TYRPHOSTIN B46 Eigenschaften
- Siedepunkt:
- 621.1±55.0 °C(Predicted)
- Dichte
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO or ethanol: soluble
- Aggregatzustand
- Powder
- pka
- 8.82±0.10(Predicted)
- Farbe
- Light yellow to yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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TYRPHOSTIN B46 Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC
50 = 0.7 μM). It selectively inhibits EFGR over ErbB2 (IC
50 = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC
50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM. It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC
50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC
50 = 210 μM).
Verwenden
Inhibitor of EGF receptor kinase activity
Biologische Aktivit?t
Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.7 μ M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G 1 growth arrest selectively in transformed cells (IC 50 values are 6.4 and 9.4 μ M in HPV16-immortalized and normal keratinocytes respectively).
TYRPHOSTIN B46 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TYRPHOSTIN B46 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 83)Lieferanten
- N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE
- N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE
- TYRPHOSTIN AG 555
- TYRPHOSTIN B46
- (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(3-PHENYLPROPYL)-2-PROPENAMIDE
- AG 555
- ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE
- Tyrphostin B46, N-(3μ-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide
- AG 555 (Tyrphostin AG 555)
- 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-, (2E)-
- TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555
- AG 555, >98%
- TYRPHOSTIN AG 555, >98%
- AG555（Tyrphostin B46）
- (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)acrylamide
- Tyrphostin AG-555,EGFR,Reverse Transcriptase,Bovine,Tyrphostin AG555,HER1,BPV,ErbB-1,Inhibitor,AG 555,Epidermal growth factor receptor,AG-555,AG555,inhibit,antiretroviral,Papillomavirus
- TyrphostinB46 AG 555
- TyrphostinB46 A 555
- 133550-34-2
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Kinase/Phosphatase Biology
- Epidermal Growth Factor Receptor (EGFR)
- Receptor Tyrosine Kinase Inhibitors
- Protein Kinase
- Intracellular Signaling
