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ChemicalBook >> CAS DataBase List >>TYRPHOSTIN B46

TYRPHOSTIN B46

CAS No.
133550-34-2
Chemical Name:
TYRPHOSTIN B46
Synonyms
AG 555;AG 555, >98%;TYRPHOSTIN B46;TYRPHOSTIN AG 555;TyrphostinB46 AG 555;TyrphostinB46 A 555;AG555（Tyrphostin B46）;TYRPHOSTIN AG 555, >98%;AG 555 (Tyrphostin AG 555);TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555
CBNumber:
CB5469835
Molecular Formula:
C19H18N2O3
Molecular Weight:
322.36
MDL Number:
MFCD00209865
MOL File:
133550-34-2.mol
Last updated:2024-11-14 14:09:35

TYRPHOSTIN B46 Properties

Boiling point 621.1±55.0 °C(Predicted)
Density 1.273±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO or ethanol: soluble
form Powder
pka 8.82±0.10(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3

TYRPHOSTIN B46 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J61704 Tyrphostin B46, 98+% 133550-34-2 10mg $152.65 2024-03-01 Buy
Alfa Aesar J61704 Tyrphostin B46, 98+% 133550-34-2 50mg $644 2021-12-16 Buy
Cayman Chemical 23247 AG-555 ≥95% 133550-34-2 5mg $48 2024-03-01 Buy
Cayman Chemical 23247 AG-555 ≥95% 133550-34-2 10mg $85 2024-03-01 Buy
Cayman Chemical 23247 AG-555 ≥95% 133550-34-2 25mg $198 2024-03-01 Buy
Product number Packaging Price Buy
J61704 10mg $152.65 Buy
J61704 50mg $644 Buy
23247 5mg $48 Buy
23247 10mg $85 Buy
23247 25mg $198 Buy

TYRPHOSTIN B46 Chemical Properties,Uses,Production

Description

AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC50 = 0.7 μM). It selectively inhibits EFGR over ErbB2 (IC50 = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM. It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC50 = 210 μM).

Uses

Inhibitor of EGF receptor kinase activity

Biological Activity

Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.7 μ M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G 1 growth arrest selectively in transformed cells (IC 50 values are 6.4 and 9.4 μ M in HPV16-immortalized and normal keratinocytes respectively).

References

[1]. ben-bassat h, rosenbaum-mitrani s, hartzstark z, et al. inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. cancer res, 1997, 57(17): 3741-3750.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. sion-vardy n, vardy d, rodeck u, et al. antiproliferative effects of tyrosine kinase inhibitors (tyrphostins) on human bladder and renal carcinoma cells. j surg res, 1995, 59(6): 675-680.
[4]. seri i, aflalo e, gazit a, et al. tyrphostin ag-555 inhibits early and late stages of moloney murine leukemia virus replication cycle. int j oncol, 1997, 10(6): 1185-1189.

TYRPHOSTIN B46 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 83)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32080 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38470 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64

View Lastest Price from TYRPHOSTIN B46 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AG 555 pictures 2024-11-16 AG 555
133550-34-2
 US $39.00-113.00 / mg 99.51% 10g TargetMol Chemicals Inc.
  • AG 555 pictures
  • AG 555
    133550-34-2
  • US $39.00-113.00 / mg
  • 99.51%
  • TargetMol Chemicals Inc.

TYRPHOSTIN B46 Spectrum

N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE TYRPHOSTIN AG 555 TYRPHOSTIN B46 (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(3-PHENYLPROPYL)-2-PROPENAMIDE AG 555 ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE Tyrphostin B46, N-(3μ-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide AG 555 (Tyrphostin AG 555) 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-, (2E)- TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555 AG 555, >98% TYRPHOSTIN AG 555, >98% AG555（Tyrphostin B46） (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)acrylamide Tyrphostin AG-555,EGFR,Reverse Transcriptase,Bovine,Tyrphostin AG555,HER1,BPV,ErbB-1,Inhibitor,AG 555,Epidermal growth factor receptor,AG-555,AG555,inhibit,antiretroviral,Papillomavirus TyrphostinB46 AG 555 TyrphostinB46 A 555 133550-34-2 BioChemical Cell Biology Cell Signaling and Neuroscience Kinase/Phosphatase Biology Epidermal Growth Factor Receptor (EGFR) Receptor Tyrosine Kinase Inhibitors Protein Kinase Intracellular Signaling