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Dolutegravir Impurity 3

Dolutegravir Impurity 3 Struktur
1973402-05-9
CAS-Nr.
1973402-05-9
Englisch Name:
Dolutegravir Impurity 3
Synonyma:
Dotiravir Impurity 3;Dolutegravir Impurity 3;Dolutegravir impurity A;Dolutegravir Impurity 51;DolutegravirImpurity9SodiumSalt;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide;N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide;2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-;Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
CBNumber:
CB53154305
Summenformel:
C20H19F2N3O5
Molgewicht:
419.38
MOL-Datei:
1973402-05-9.mol

Dolutegravir Impurity 3 Eigenschaften

Schmelzpunkt:
95-100°C
Siedepunkt:
662.3±55.0 °C(Predicted)
Dichte
1.51±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
4.50±1.00(Predicted)
Farbe
Yellow

Sicherheit

Dolutegravir Impurity 3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir Impurity 3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Dolutegravir Impurity 3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 33)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Standardpharm Co. Ltd. 		86-714-3992388
overseasales1@yongstandards.com United States 14332 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551
sales@afinechem.com China 15352 58
CR Corporation Limited 		+8613062833949
 fred.wen@crcorporation.cn China 8647 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522
 overseasales@yongstandards.com China 11922 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Guangzhou CATO Research Chemicals Inc. 		+86-020-81960175-617 +8615602392859
 Intermediate@cato-chem.com China 8322 58
Moxin Chemicals 		+8617320513646
 mike@molcoo.com China 9511 58
Aurisco Pharmaceutical (Tianjin) Inc. 022-59885855
China 96 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412
 3001272453@qq.com China 5047 50
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
 sales@chem-strong.com China 18070 56
  • Dolutegravir Impurity 3
  • (R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
  • (R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p
  • Dolutegravir Impurity 51
  • N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
  • Dolutegravir impurity A
  • 2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
  • Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
  • DolutegravirImpurity9SodiumSalt
  • Dotiravir Impurity 3
  • 1973402-05-9
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