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Dolutegravir Impurity 3

化學(xué)構(gòu)造式
1973402-05-9
CAS番號(hào).
1973402-05-9
化學(xué)名:
別名:
英語(yǔ)名:
Dolutegravir Impurity 3
英語(yǔ)別名:
Dotiravir Impurity 3;Dolutegravir Impurity 3;Dolutegravir impurity A;Dolutegravir Impurity 51;DolutegravirImpurity9SodiumSalt;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide;N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide;2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-;Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
CBNumber:
CB53154305
化學(xué)式:
C20H19F2N3O5
分子量:
419.38
MOL File:
1973402-05-9.mol

Dolutegravir Impurity 3 物理性質(zhì)

融點(diǎn) :
95-100°C
沸點(diǎn) :
662.3±55.0 °C(Predicted)
比重(密度) :
1.51±0.1 g/cm3(Predicted)
貯蔵溫度 :
-20°C Freezer, Under inert atmosphere
溶解性:
DMSO（微量）、メタノール（微量）
外見(jiàn) :
個(gè)體
酸解離定數(shù)(Pka):
4.50±1.00(Predicted)
色:
黃色

安全性情報(bào)

Dolutegravir Impurity 3 価格

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購(gòu)入

Dolutegravir Impurity 3 化學(xué)特性,用途語(yǔ),生産方法

使用

(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir Impurity 3 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

Dolutegravir Impurity 3 生産企業(yè)

Global( 32)Suppliers
名前 電話(huà)番號(hào) 電子メール 國(guó)籍 製品カタログ 優(yōu)位度
Standardpharm Co. Ltd. 		86-714-3992388
overseasales1@yongstandards.com United States 14332 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551
sales@afinechem.com China 15352 58
CR Corporation Limited 		+8613062833949
 fred.wen@crcorporation.cn China 8647 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522
 overseasales@yongstandards.com China 11922 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Moxin Chemicals 		+8617320513646
 mike@molcoo.com China 9683 58
Aurisco Pharmaceutical (Tianjin) Inc. 022-59885855
China 96 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412
 3001272453@qq.com China 5047 50
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
 sales@chem-strong.com China 18101 56
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656
 greensnown@163.com China 9906 50

1973402-05-9()キーワード:

  • 1973402-05-9
  • Dolutegravir Impurity 3
  • (R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
  • (R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p
  • Dolutegravir Impurity 51
  • N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
  • Dolutegravir impurity A
  • 2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
  • Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
  • DolutegravirImpurity9SodiumSalt
  • Dotiravir Impurity 3
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