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Sodium 4-phenylbutyrate

Sodium 4-phenylbutyrate Struktur
1716-12-7
CAS-Nr.
1716-12-7
Englisch Name:
Sodium 4-phenylbutyrate
Synonyma:
SODIUM PHENYLBUTYRATE;PBNA;4PBA;Tributyrate;Ammonaps;Nsc657802;4PBA SODIUM;4-PHENYLBUTYRATE;4-PHENYLBUTYRATE, NA;Sodium 4-Phenylbutyr
CBNumber:
CB5213148
Summenformel:
C10H13NaO2
Molgewicht:
188.2
MOL-Datei:
1716-12-7.mol

Sodium 4-phenylbutyrate Eigenschaften

Schmelzpunkt:
224-226°C (dec.)
storage temp. 
room temp
L?slichkeit
H2O: ≥5mg/mL
Aggregatzustand
White to slightly yellow solid
Farbe
white to beige
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
InChI
InChI=1S/C10H12O2.Na.H/c11-10(12)8-4-7-9-5-2-1-3-6-9;;/h1-3,5-6H,4,7-8H2,(H,11,12);;
InChIKey
OBKXEAXTFZPCHS-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1)CCC(=O)O.[NaH]
CAS Datenbank
1716-12-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36
S-S?tze: 26
WGK Germany  3
RTECS-Nr. CY9057220
HS Code  29163990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Sodium 4-phenylbutyrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.
Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Chemische Eigenschaften

White or yellowish-white powder.

Verwenden

ACE inhibitor, antihypertensive, Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.

Definition

ChEBI: The organic sodium salt of 4-phenylbutyric acid. A prodrug for phenylacetate, it is used to treat urea cycle disorders.

Allgemeine Beschreibung

An antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of δF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo.

Biologische Aktivit?t

Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.

Nebenwirkungen

Loss of appetite or menstrual changes (delayed/irregular/absent periods) may occur. Serious side effects including: drowsiness/lightheadedness, easy bruising/bleeding, fast/pounding heartbeat, mental/mood changes, tiredness, signs of metabolic imbalance (such as rapid breathing, muscle twitching/spasms).

Sodium 4-phenylbutyrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sodium 4-phenylbutyrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 291)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changzhou uniringchem Co., Ltd.
+undefined13585446801
sales@uniringchem.com China 68 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 18829239519
sales06@tgybio.com China 901 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20283 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9083 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272
info@edengenechem.com China 2158 58

1716-12-7()Verwandte Suche:


  • SODIUM 4-PHENYLBUTYRATE
  • PHENYL N-BUTYRATE SODIUM SALT
  • 4-PHENYLBUTYRATE, NA
  • 4-PHENYLBUTYRIC ACID SODIUM
  • 4-PHENYLBUTYRIC ACID SODIUM SALT
  • 4PBA SODIUM
  • Nsc657802
  • SodiuM 4-Phenylbutanoate
  • 4-PHENYLBUTYRATE
  • Benzenebutanoic acid,sodiuM salt (1:1)
  • Sodium Phenylbutyrate (200 mg)
  • Sodium phenylbutyrate, >=98%
  • Sodium phenylbutyrate, 98%, a histone deacetylase inhibitor
  • Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem
  • Benzenebutyric acid sodium
  • Sodium phenylbutyrate CRS
  • Sodium 4-phenylbutyrate USP/EP/BP
  • Sodium 4-Phenylbutyr
  • Ammonaps
  • Sodium Phenylbutyrate (4-PBA sodium)
  • Sodium Phenylbutyrate (1614512)
  • SODIUM PHENYLBUTYRATE
  • PBNA
  • 4PBA
  • Tributyrate
  • 4-Phenylbutyric acid sodium in Acetonitrile:Water=9:1
  • 1716-12-7
  • 716-12-7
  • C10H11O2Na
  • C10H11NaO2
  • VASOTEC
  • 1716-12-7
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