5-Methyl-2-pyridon
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- CAS-Nr.
- 1003-68-5
- Bezeichnung:
- 5-Methyl-2-pyridon
- Englisch Name:
- 2-Hydroxy-5-methylpyridine
- Synonyma:
- 5-Methylpyridin-2(1H)-one;2(1H)-Pyridinone, 5-methyl-;5-methyl-2-pyridone;2-HYDROXY-5-PICOLINE;AKOS BBS-00002970;2-Hydroxy-5-methyL;5-METHYL-2-PYRIDINOL;6-HYDROXY-3-PICOLINE;5-METHYL-PYRIDIN-2-OL;2-Hydroxy-5-Piocoline
- CBNumber:
- CB5114924
- Summenformel:
- C6H7NO
- Molgewicht:
- 109.13
- MOL-Datei:
- 1003-68-5.mol
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5-Methyl-2-pyridon Eigenschaften
- Schmelzpunkt:
- 183-187 °C (lit.)
- Siedepunkt:
- 304.2±15.0 °C(Predicted)
- Dichte
- 1.053±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 12.43±0.10(Predicted)
- Farbe
- Pale Yellow to Light Yellow
- BRN
- 107074
- InChI
- InChI=1S/C6H7NO/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8)
- InChIKey
- SOHMZGMHXUQHGE-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(C)C=C1
- CAS Datenbank
- 1003-68-5(CAS DataBase Reference)
- NIST chemische Informationen
- 2(1H)-pyridinone, 5-methyl-(1003-68-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
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5-Methyl-2-pyridon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augensch?den.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Solid
Verwenden
2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. 2-hydroxy-5-methylpyridine and Iodobenzene were the impurities present in Pirfenidone (PFD) drug substance. PFD is a novel antifibrotic agent approved for mild to moderate Idiopathic pulmonary fibrosis (IPF) as orphan drug[1].
Synthese
3-cyano-6-hydroxypyridine and sodium lauryl sulfate were added to a mixed solvent of n-butanol and water. Subsequently, the temperature was raised to 50 °C., and sulfuric acid water obtained by dissolving 98% sulfuric acid in water was added dropwise at the temperature. After stirring for about 20 minutes, the mixture was cooled to room temperature, and 5% Pd / C was added. The system was replaced with hydrogen, and hydrogenation was carried out at atmospheric pressure for 6 hours. After the reaction was completed, the catalyst was removed by filtration, and the solution was washed with 10% sodium hydroxide aqueous solution. After partially neutralizing to H = 5 and extraction with n-butanol, a solution of crude 3-methyl-6-hydroxypyridine in butanol was obtained. When this solution was quantified by liquid chromatography, the pass-through rate was 99.2%, and the yield of 2-hydroxy-5-methylpyridine was 83%.
5-Methyl-2-pyridon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Methyl-2-pyridon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 466)Lieferanten
1003-68-5(5-Methyl-2-pyridon)Verwandte Suche:
- 6-HYDROXY-3-PICOLINE
- 5-METHYL-2(1H)PYPRIDINONE
- 5-METHYL-2(1H)-PYRIDINONE
- 5-METHYL-2(1H)PYRIDONE
- 5-METHYL-2-PYRIDINOL
- 5-METHYL-PYRIDIN-2-OL
- 5-METHYLPYRIDINE-2-ONE
- AKOS BBS-00002970
- 2-HYDROXY-5-METHYLPYRIDINE
- 2-Hydroxy-5-Picoline 2-Hydroxy-5-Methyl Pyridine
- 2-HYDROXY-5-METHYLPYRIDINE 98%
- 2-Hydroxy-5-Piocoline
- 2(1H)-Pyridone, 5-methyl-
- 2-Methyl-6-hydroxypyridine
- 5-Methyl-1,2-dihydropyridine-2-one
- 5-Methylpyridine-2-ol
- 2-Hydroxy-5-methylpyridine
5-Methyl-2(1H)pypridinone
2-Hydroxy-5-picoline
- 2-Hydroxy-5-methylpyridine ,98%
- 1,2-Dihydro-5-methyl-2-oxopyridine
- 5-Methyl-2-oxopyridine
- 6-Hydroxy-3-picoline
5-Methyl-2-pyridinol
5-Methyl-2(1H)-pyridinone
- Hydroxy-5-Methylpyrid
- 5-methyl-(1H)pyridinone
- Pirfenidone Impurity 2（Pirfenidone EP Impurity B）
- 2-Hydroxy-5-methyL
- (91914-06-6) 2-hydroxy-5-methylpyridine
- Perfenidone Impurity 1
- 5-Methylpyridin-2(1H)-one 98%
- 2-Hydroxy-5-methylpyridine>
- 2-Hydro-5-methylpyridine
- 2-Hydroxy-5-methylpyridine ISO 9001：2015 REACH
- Big Discount Purity 99% 2-Hydroxy-5-Methylpyridine CAS 1003-68-5 with Best Quality
- 5-methyl-1,2-dihydropyridin-2-one
- 5-Methylpyridin-2(1H)-one
- 2(1H)-Pyridinone, 5-methyl-
- 5-methyl-2-pyridone
- 2-HYDROXY-5-PICOLINE
- 2-HYDROXY-5-METHYLPYRIDINEE
- Pirfenidone EP Impurity B
5-methylpyridin-2(1H)-one
- 1003-68-5
- Building Blocks
- C6
- Heterocyclic Building Blocks
- Pyridines
- Imidazoles
- Heterocycle-Pyridine series
- alcohol
- Pyridine
- Pyridines
- Chemical Amines
- Amines
- Aromatics
- Heterocycles
- C6
- Heterocyclic Building Blocks
