CUCURBITACIN B
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- CAS-Nr.
- 6199-67-3
- Englisch Name:
- CUCURBITACIN B
- Synonyma:
- Cuc B;AMARINE;HSDB 3476;DATISCACIN;NSC-144154;heMsecin A;Cucurbitacin;cucuritacin B;CUCURBITACIN B;cucurbitacineb
- CBNumber:
- CB5113260
- Summenformel:
- C32H46O8
- Molgewicht:
- 558.7
- MOL-Datei:
- 6199-67-3.mol
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CUCURBITACIN B Eigenschaften
- Schmelzpunkt:
- 184-186°
- alpha
- D25 +88° (c = 1.55 in ethanol)
- Siedepunkt:
- 546.74°C (rough estimate)
- Dichte
- 1.0953 (rough estimate)
- Brechungsindex
- 1.4900 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- pka
- 12.60±0.29(Predicted)
- Farbe
- white to beige
- maximale Wellenl?nge (λmax)
- 290nm(EtOH)(lit.)
- Merck
- 14,2614
- Stabilit?t:
- Hygroscopic
- InChIKey
- IXQKXEUSCPEQRD-ALLWXVAWSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45-24/25 |
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| RIDADR |
UN 2811 6.1 / PGI |
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| WGK Germany |
3 |
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| RTECS-Nr. |
RC6190000 |
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| HazardClass |
6.1 |
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| PackingGroup |
II |
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| HS Code |
29153900 |
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| Giftige Stoffe Daten |
6199-67-3(Hazardous Substances Data) |
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| Toxizit?t |
LD10 orally in mice: 5 mg/kg (LeMen) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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CUCURBITACIN B Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White solid
Verwenden
Cucurbitacin B hydrate has been used:
- as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
- as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
- to determine its effect on the cell viability of pancreatic cancer cell lines.
Definition
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
CUCURBITACIN B Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CUCURBITACIN B Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 274)Lieferanten
6199-67-3()Verwandte Suche:
2,16α,20,25-Tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-trien-3,11,22-trion-25-acetat
2,16α,20,25-Tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-trien-3,11,22-trion
4-tert-Butylcyclohexanon
- (2beta,9beta,10alpha,16alpha,23e)-thyl
- 19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25
- 19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet
- 19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me
- 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr
- Cucurbitacin B hydrate
- cucurbitacineb
- AMARINE
- 1,2-DIHYDRO-ALPHA-ELATERIN
- CUCURBITACIN B
- DATISCACIN
- Dihydrocucurbitacin F-25-acetate
- Cucurbitacin
- HSDB 3476
- CUCURBITACIN B(RG)
- (23E)-25-(Acetyloxy)-2β,16α,20-trihydroxycucurbita-5,23-diene-3,11,22-trione
- (9β,10α,23E)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
- NSC-144154
- Cucurbitacin B ,97%
- CUCURBITACIN B(P)
- heMsecin A
- Cucurbitacin B, froM CucuMis Melo
- (2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione
- Cucurbitacin B, 98%, from Cucumis melo L.
- Cucurbitacin B, >99%
- Cucurbitacin B, 98%, from Cucumis melo
- BCucurbitacin B
- Cuc B
- 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-
- CUCURBITACIN B USP/EP/BP
- CAS?6199-67-3?Combretastatin A4 (Z) -Combretastatin A4 CAS 117048-59-6
- cucuritacin B
- (+)-Cucurbitacin B
- (R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate
- 1,2-Dihydro-a-elaterin
- Cucurbitacin B-RM
- Cucurbitacin B, 10 mM in DMSO
- 6199-67-3
- C32H46O8
- Tri-Terpenoids
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
