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(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid

Pivampicillin Hydrochloride Struktur
26309-95-5
CAS-Nr.
26309-95-5
Bezeichnung:
(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid
Englisch Name:
Pivampicillin Hydrochloride
Synonyma:
Devonium;Centurina;Alphacillin;Alphacilina;Sanguicillin;PIVAMPICILLINHYDROCHLORIDE;AMpicillin PivaloxyoxyMethyl Ester Hydrochloride;6β-((R)-2-amino-2-phenyl-acetylamino)-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester;(pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride;(pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
CBNumber:
CB4934172
Summenformel:
C22H30ClN3O6S
Molgewicht:
500.0081
MOL-Datei:
26309-95-5.mol

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Eigenschaften

Schmelzpunkt:
155-156° (decomp)
alpha 
D20 +196° (c = 1 in water)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
L?slichkeit
DMSO (Slightly), Water (Slightly, Sonicated)
pka
pKa ~7.0(at 25℃)
Aggregatzustand
Solid
Farbe
White

Sicherheit

Toxizit?t LD50 in mice, rats (g/kg): 3.34, 5.00 orally; 3.60, 4.50 s.c. (von Daehne)

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Semi-synthetic antibiotic related to Penicillin (P223500). Antibacterial.

Kontakt-Allergie

Pivampicillin is a prodrug of ampicillin. It caused sensitization in 56 workers at a penicillin factory. Pivampicillin and pivmecillinam were responsible for contact dermatitis in pharmaceutical production workers. Ampicillin, mecillinam or amdinocillin, penicillin V and penicillin G were also implicated in cross-reactions.

Sicherheitsprofil

Moderately toxic by ingestion andsubcutaneous routes. When heated todecomposition it emits very toxic fumes of NOx, SOx, andHCl.

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Wasserstoff Chlormethylpivalat

Downstream Produkte

(Pivaloyloxy)methyl-[2S-[2α,5α,6β(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylatmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 13)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15402 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
 sales@rrkchem.com China 57423 58
Energy Chemical 021-58432009 400-005-6266
 marketing1@energy-chemical.com China 44806 58
Guangzhou Austine Biotechnology Co., LTD 17727342298
 2781109436@qq.com China 2003 58
4008-099-669
 23419001name@qq.com CHINA 73043 58
United States Biological --
 sales@advtechind.com United States 6075 58
  • (pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
  • PIVAMPICILLINHYDROCHLORIDE
  • (2S,5R,6R)-6-[[(2R)-2-AMino-2-phenylacetyl]aMino]-3,3-diMethyl-7-oxo-4-thia- 1-azabicyclo[3.2.0]heptane-2-carboxylic Acid (2,2-DiMethyl-1-oxopropoxy)Methyl Ester Hydrochloride
  • Alphacilina
  • Alphacillin
  • AMpicillin PivaloxyoxyMethyl Ester Hydrochloride
  • 6β-((R)-2-amino-2-phenyl-acetylamino)-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester
  • Centurina
  • Devonium
  • Sanguicillin
  • (pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
  • 26309-95-5
  • C22H30ClN3O6S
  • C22H29N3O6SClH
  • Sulfur & Selenium Compounds
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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