Trimipramin
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- CAS-Nr.
- 739-71-9
- Bezeichnung:
- Trimipramin
- Englisch Name:
- TRIMIPRAMINE
- Synonyma:
- 7162rp;il6001;7162 RP;FI 6120;IL 6001;RP-7162;Stangyl;Sapilent;Surmontil;Rhotrimine
- CBNumber:
- CB4490399
- Summenformel:
- C20H26N2
- Molgewicht:
- 294.43
- MOL-Datei:
- 739-71-9.mol
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Trimipramin Eigenschaften
- Schmelzpunkt:
- 45°
- Siedepunkt:
- 426.2°C (rough estimate)
- Dichte
- 0.9912 (rough estimate)
- Brechungsindex
- 1.6450 (estimate)
- Flammpunkt:
- 9℃
- storage temp.
- 2-8°C
- pka
- pKa 8.0 (Uncertain)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
F,T |
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| R-S?tze: |
11-23/24/25-39/23/24/25 |
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| S-S?tze: |
16-36/37-45 |
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| RIDADR |
3249 |
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| WGK Germany |
1 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| Toxizit?t |
LD50 oral in mouse: 250mg/kg |
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| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P311 |
GIFTINFORMATIONSZENTRUM/Arzt anrufen. |
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Trimipramin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Antidepressant.
Definition
ChEBI: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)-2-methylpropyl group at the nitrogen atom. It is used as an antidepressant.
Weltgesundheitsorganisation (WHO)
Trimipramine, a tricyclic antidepressant was introduced in 1961
for the management of endogenous depression. Much of the adverse effects are
caused by its antimuscarinic actions. These include dry mouth, cardiac
arrhythmias, central nervous system disturbances, blood disorders and risk of
suicide. The risk of suicide and dangers related to overdosage led Norwegian
Medicines Control Authority to put the higher strength formulation under
prescribing restriction in 1992. The risk of death following overdosage is
apparently higher for products containing tricyclic compounds as compared with
nontricyclic products.
Pharmakokinetik
Trimipramine is one of the antidepressants with the most pronounced differences in pharmacokinetics caused
by the CYP2D6 genetic polymorphism. Its bioavailability and systemic clearance depended
significantly on the CYP2D6 isoform with a linear dose relationship. Its mean bioavailability was 44% in
individuals without CYP2D6 (poor metabolizers) but 16 and 12% in those individuals with two and three active
genes of CYP2D6 (fast and ultrafast metabolizers), respectively. Consequently, the mean total clearances of
the oral dose were 27, 151, and 253 L/hour in poor, extensive, and ultrarapid metabolizers, respectively. The
44% bioavailability combined with low systemic clearance of trimipramine in poor metabolizers of CYP2D6
substrates results in a very high exposure to trimipramine with the risk of adverse drug reactions. On the
other hand, the presystemic elimination may result in subtherapeutic drug concentrations in carriers of
CYP2D6 gene duplications with a high risk of poor therapeutic response
Clinical Use
Although trimipramine has the weakest binding affinity for the monoamine transporters, it shares the pharmacological and toxicity actions of the other TCAs and is used primarily in the
treatment of depression.
Trimipramin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Trimipramin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 43)Lieferanten
739-71-9(Trimipramin)Verwandte Suche:
- 2’-metil-3’-dimetilamino-propil-5-iminodibenzile
- 2'-Metil-3'-dimetilamino-propil-5-iminodibenzile
- 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethyl-1-propanamine
- 5-(3-(Dimethylamino)-2-methylpropyl)-10,11-dihydro-5H-dibenz(b,f)azepine
- 5-(gamma-dimethylamino-beta-methylpropyl)-10,11-dihydro-5h-dibenzo(b,f)azepi
- 5-(gamma-Dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
- 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-
- 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-
- 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-
- 7162 RP
- 7162rp
- beta-Methylimipramine
- f)azepine,10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-5h-dibenz(
- f)azepine,5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-5h-dibenz(
- TRIMIPRAMINE
- 1-(3-Dimethylamino-2-methylpropyl)-4,5-dihydro-2,3:6,7-dibenzazepine
- 10,11-Dihydro-5-(3-dimethylamino-2-methylpropyl)-5H-dibenz(b,f)azepine
- f)azepine-5-propanamine,10,11-dihydro-n,n,beta-trimethyl-5h-dibenz(
- FI 6120
- IL 6001
- il6001
- Rhotrimine
- RP-7162
- Sapilent
- Surmontil
- Surmontil 315695
- surmontil315695
- Trimeprimina
- Trimeprimine
- Trimeproprimine
- TRIMIDRAMINE
- TRIMIPRAMINE,1.0MG/MLINMETHANOL
- 5-(g-Dimethylamino-b-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
- 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro- (6CI, 7CI, 8CI)
- 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,b-trimethyl- (9CI)
- b-Methylimipramine
- Trimipramine (base and/or unspecified salts)
- Trimipramine solution
- 5-(3-dimethylamino-2-methylpropyl)-10,11-dihydrodibenz(b,f)azepine
- Trimipramine Solution, 100ppm
- 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,β-trimethyl-
- TRIMIPRAMINE USP/EP/BP
- 5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N,b-trimethyl-
- Stangyl
- 739-71-9
