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10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin

IMIPRAMINE Struktur
50-49-7
CAS-Nr.
50-49-7
Bezeichnung:
10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin
Englisch Name:
IMIPRAMINE
Synonyma:
IM;DPID;Irmin;Iramil;Imizin;Imiprin;Imizine;Surplix;Timolet;Censtim
CBNumber:
CB1727489
Summenformel:
C19H24N2
Molgewicht:
280.41
MOL-Datei:
50-49-7.mol

10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Eigenschaften

Schmelzpunkt:
174°C
Siedepunkt:
bp0.1 160°
Dichte
0.9935 (rough estimate)
Brechungsindex
1.5640 (estimate)
pka
pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
Aggregatzustand
Liquid
Farbe
Colorless to light yellow
Wasserl?slichkeit
18.23mg/L(24 ºC)
Solvent
Ethanol under nitrogen
Concentration
1 mCi/ml
Specific Activity
60-90 Ci/mmol
BCS Class
1
EPA chemische Informationen
Imipramine (50-49-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Giftige Stoffe Daten 50-49-7(Hazardous Substances Data)
Toxizit?t A tertiary amine tricyclic antidepressant that is thought to exert its therapeutic effect by inhibiting the reuptake of serotonin and norepinephrine centrally. A major metabolite is N-desmethylimipramine (desipramine), also used as an antidepressant drug. Desipramine differs from imipramine in being a better blocker of norepinephrine, rather than serotonin, uptake. Side effects, including sedation and drowsiness, dry mouth, urinary retention, constipation, and orthostatic hypotension, are probably due to the anticholinergic, anti-α-adrenergic, and antihistaminergic receptor-blocking properties. Imipramine should not be used in conjunction with a monoamine oxidase inhibitor or other treatment that increases catecholamine concentrations (e.g., drugs containing sympathomimetic amines). Imipramine should be avoided in patients with cardiovascular disease or seizure disorder, or in those who may abuse alcohol, as imipramine lowers seizure threshold, can produce cardiovascular toxicity and may potentiate the effects of alcohol. Imipramine intoxication can include CNS abnormalities (e.g., drowsiness, stupor, coma, and extrapyramidal symptoms), cardiac arrhythmia, and respiratory depression. Children appear to be particularly vulnerable to the cardiotoxic and seizure-inducing effects of high doses of imipramine. The oral LD50 in female rats is 305 mg/kg.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H370 Sch?digt die Organe. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P307+P311, P321,P405, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P307+P311 BEI Exposition: GIFTINFORMATIONSZENTRUM oder Arzt anrufen.
P312 Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P321 Besondere Behandlung
P403+P233 An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Imipramine is used in depression of various etiology accompanied by motor clumsiness and enuresis in children and Parkinson’s disease.

Mechanism of action

Besides being used in the clinical treatment of depression, imipramine also has been used for the treatment of functional enuresis in children who are at least 6 years of age (25 mg daily administered 1 hour before bedtime, not to exceed 2.5 mg/kg daily).

Clinical Use

Imipramine is a 10,11-dihydrodibenzazepine tertiary amine TCA that is marketed as hydrochloride and pamoate salts, both of which are administered orally. Although the hydrochloride salt may be administered in divided daily doses, imipramine's long duration of action suggests that the entire oral daily dose may be administered at one time.On the other hand, imipramine pamoate usually is administered as a single daily oral dose.

10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 71)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Hong Kong Tiansheng New Material Trading Co., Ltd
+8617320695765
zxx@hktiansheng.com China 973 58
Hebei baicao biology science and technology co., ltd
+86-19131911055 +8617824879454
zhang@hbbocao.com China 1029 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24727 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58

50-49-7(10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin)Verwandte Suche:


  • IM
  • Imidobenzyle
  • Imipramina
  • Imiprin
  • Imizin
  • Imizine
  • Imizinum
  • Impramine
  • Intalpram
  • Iramil
  • Irmin
  • Melipramin
  • Melipramine
  • N-(3-Dimethylaminopropyl)-o-iminodibenzyl
  • N-(gamma-Dimethylaminopropyl)iminodibenzyl
  • Nelipramin
  • Prazepine
  • Promiben
  • Psychoforin
  • SK-Pramine
  • Surplix
  • Timolet
  • Tofranil (free base)
  • Tofranil, base
  • Tofraniln A
  • 3-(10,11-dihydrodibenz(b,f)azepin-5-yl)propyldimethylamine
  • N-[γ-Dimethylaminopropyl] iminodibenzyl
  • IMIPRAMINE,1.0MG/MLINMETHANOL
  • IMIPRAMINE
  • AURORA KA-7708
  • 1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine
  • 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine
  • 2,2'-(3-Dimethylaminopropylimino)bibenzyl
  • 2,2'-(3-Dimethylaminopropylimino)dibenzyl
  • 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
  • 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
  • 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
  • 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-
  • 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
  • 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-
  • Antideprin
  • Berkomine
  • Censtim
  • Censtin
  • Declomipramine
  • Dimipressin
  • DPID
  • Dynaprin
  • Eupramin
  • Imipramine (base and/or unspecified salts)
  • N-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine
  • 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-(1-propanamine)
  • 3-(4a,5-dihydro-4H-dibenzo[b,f]azepin-10-yl)-N,N-diMethylpropan-1-aMine
  • 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
  • Clomipramine HCl EP Impurity B
  • Trimipramine BP Impurity D
  • Imipramine for system suitability CRS
  • Imipramine (Clomipramine EP Impurity B)
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