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2,2'-(Piperazin-1,4-diyl)bis(ethansulfonsaeure)

PIPES Struktur
5625-37-6
CAS-Nr.
5625-37-6
Bezeichnung:
2,2'-(Piperazin-1,4-diyl)bis(ethansulfonsaeure)
Englisch Name:
PIPES
Synonyma:
PIPES FREE ACID;1,4-Piperazinebis(ethanesulphonic acid);PIPES;PIPES,98%;PIPES0215;Pipes AR 98%;PIPES【Dotite】;Pipes(Buffer);PIPES solution;MOLYBDENE STAND
CBNumber:
CB4435134
Summenformel:
C8H18N2O6S2
Molgewicht:
302.37
MOL-Datei:
5625-37-6.mol

2,2'-(Piperazin-1,4-diyl)bis(ethansulfonsaeure) Eigenschaften

Schmelzpunkt:
>300 °C (lit.)
Dichte
1.4983 (rough estimate)
Brechungsindex
1.6300 (estimate)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
0.1 M NaOH: 0.25 g/mL, clear, colorless
Aggregatzustand
Micro-Crystalline Powder
Farbe
White
pka
6.8(at 25℃)
S?ure-Base-Indikators(pH-Indikatoren)
6.1 - 7.5
Wasserl?slichkeit
Soluble in water.
maximale Wellenl?nge (λmax)
λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.040
Merck 
14,7479
BRN 
817713
InChIKey
XWGRYGKFRRLUQQ-UHFFFAOYSA-N
LogP
-2.7 at 20℃
CAS Datenbank
5625-37-6(CAS DataBase Reference)
EPA chemische Informationen
1,4-Piperazinediethanesulfonic acid (5625-37-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 22-24/25-37/39-26
WGK Germany  3
TSCA  Yes
HS Code  29335995
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

2,2'-(Piperazin-1,4-diyl)bis(ethansulfonsaeure) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

PIPES is a member of the ethanesulfonic acid buffer series, first introduced by Good et al., developed to meet certain criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range and easily synthesized. Since its pKa at 37 °C is near physiological pH, PIPES has applications in cell culture work.

Chemische Eigenschaften

White/clear crystalline powder

Verwenden

A buffering agent with a pKa near physiological pH.PIPES [piperazine-N,N′-bis(2-ethanesulfonic acid)] is frequently used as a buffering agent in biochemistry. It is an ethanesulfonic acid buffer developed by Good et al. in the 1960s. PIPES has a pKa near the physiological pH which makes it useful in cell culture work. It has been documented to minimize lipid loss when buffering glutaraldehyde histology in plant and animal tissues.
Additional forms available: PIPES, Sesquisodium Salt ; PIPES dipotassium salt; PIPES disodium salt; PIPES, Sodium Salt. Buffers can be prepared by adding a solution of base to PIPES free acid, titrating to the appropriate pH, or by mixing equimolar solutions of the monosodium salt and the disodium salt, titrating to the appropriate pH.

Application

Glutaraldehyde fixation of plant and animal tissue samples can cause loss of lipid, leading to apparent morphological changes. Lipid loss and artifacts were minimized when PIPES was used to buffer the glutaraldehyde fixative.
Alkaline phosphatase activity is lost selectively from certain rat hepatocyte organelles when fixed for ultracytochemistry with cacodylate-buffered glutaraldehyde. When PIPES was used as buffer, retention of activity was 60% greater.
Fixation of fungal zoospores for fluorescence microscopy and electron microscopy was optimal with a combination of glutaraldehyde and formaldehyde in PIPES buffer.

Allgemeine Beschreibung

PIPES is a member of the ethanesulfonic acid buffer series, first introduced by Good et al., developed to meet certain criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range and easily synthesized. Since its pKa at 37 °C is near physiological pH, PIPES has applications in cell culture work.

l?uterung methode

Purify PIPES from boiling water (maximum solubility is about 1g/L) or as described for ADA [N-(2-acetamido)iminodiacetic acid above]. [Good et al. Biochemistry 5 469 1966, Beilstein 23/12 V 380.]

2,2'-(Piperazin-1,4-diyl)bis(ethansulfonsaeure) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2,2'-(Piperazin-1,4-diyl)bis(ethansulfonsaeure) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 438)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Tangshan Moneide Trading Co., Ltd.
+86-315-8309571 +8615633399667
sales@moneidechem.com China 574 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24727 58
Jiangsu Boquan Biotechnology Co., Ltd.
+86-18168774353
boquanshengwu003@boquansw.com China 248 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Hebei Fengjia New Material Co., Ltd
+86-0311-87836622 +86-17333973358
sales06@hbduling.cn China 8054 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18754 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21637 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075
jack.li@time-chemicals.com China 1803 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29885 58

5625-37-6(2,2'-(Piperazin-1,4-diyl)bis(ethansulfonsaeure))Verwandte Suche:


  • PIPES,98%
  • PIPES Piperazine-1,4-bisethanesulfonic acid
  • PIPES Vetec(TM) reagent grade, >=99%
  • ABTS DIAMMONIUM SALT ULTRA PURE GRADE
  • MOLYBDENE STAND
  • MOLYBDENUM STAND
  • PIPES BIOXTRA, FOR MOLECULAR BIOLOGY
  • PIPES, BIOPERFORMANCE CERTIFIED&
  • LABOTEST-BB LT00138111
  • 1,4-PIPERAZINEBIS(ETHANESULFONIC ACID)
  • 1,4-PIPERAZINEDIETHANESULFONIC ACID
  • PIPERAZINE-1,4-BIS(2-ETHANESULFONIC ACID)
  • PIPERAZINE-NN'-BIS-2-ETHANESULPHONIC ACID
  • PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
  • PIPES
  • TIMTEC-BB SBB008973
  • 2,2-(piperazine-1,4-diyl)bis(ethanesulphonic) acid
  • PIPES Piperazine-N,N-bis(2-ethanesulfonic acid)
  • PIPES, Free Acid, MB Grade (1.12030)
  • PIPES, Free Acid, ULTROL Grade
  • PIPES, Molecular Biology Grade Piperazine-N,N-bis(2-ethanesulfonic acid), Molecular Biology Grade
  • Piperazine-1,4-bis(ethanesulfonic acid)
  • PIPERAZINE-1 4-BIS(2-ETHANESULFONIC ACI&
  • PIPES FREE ACID SIGMAULTRA
  • PIPES FREE ACID, BIOTECHNOLOGY PERFORMAN CE CERTIFIE
  • PIPERAZINE-1,4-BIS(2-ETHANESULFONIC ACID ), F. MOL.BIOLOGY
  • SODIUM BIS(TRIMETHYLSILYL)AMIDE SOLUTION, WACKER QUALITY
  • Pipes(Buffer)-(Piperazine-N,N-Bis-2-EtheneSulfonicAcid)
  • 1,4-Piperazinediethanesulfonic acid(PIPES)
  • Piperazine-1,4-diethyl acid
  • PIPES (Piperazin-1,4-bis(2-ethansulfonic acid)
  • Piperazine-N,N'-bis-2-ethanesulphonic acid ,99%
  • PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID) ANALYTICAL GRADE
  • PIPERAZINE-N,N'-BIS(2-ETHANE SULFONIC ACID)MOLECULAR BIOLOGY GRADE
  • PIPES,1,4-Piperazinediethanesulfonic acid, Piperazine-1,4-bis(2-ethanesulfonic acid), Piperazine-N,N′-bis(2-ethanesulfonic acid)
  • PIPES free acid, molecular biology grade
  • 1,4-Piperazinedietha
  • PIPES, Free Acid, ULTROL
  • PIPES (PIPERAZINE-1,4-BIS(2-ETHANESULFONIC ACID))
  • PIPES ULTRAPURE
  • PIPERAZINE-N,N-BIS(2-ETHANESULFONICACID)(PIPES)
  • Piperazine-N,N'-bis-(2-ethanesulphonic acid) ultrapure >99.5%
  • 1,4-Piperazinediethanesulfonic acid, Piperazine-1,4-bis(2-ethanesulfonic acid), Piperazine-N,Nμ-bis(2-ethanesulfonic acid)
  • 1,4-Piperazinebis(ethansulfonic acid)
  • 2,2'-(Piperazine-1,4-diyl)bis(ethanesulfonic) acid
  • 2-[4-(2-Sulfoethyl)piperazin-1-yl]ethanesulfonic acid
  • Pipes, 98.5+%, for biochemistry
  • PIPES, for biochemistry
  • 2,2'-(1,4-Piperazinediyl)bis(ethanesulfonic acid)
  • 2,2'-(1,4-Piperazinediyl)bisethanesulfonic acid
  • PIPES【Dotite】
  • 2,2'-(Piperazine-1,4-diyl)diethanesulfonic acid
  • Pipes(Buffer)
  • PIPES, for biochemistry, 98.5+%
  • Piperazine-1,4-bis(2-ethanesulfonic acid)(PIPES)
  • 1,4-Piperazinediethanesulfonic
  • PIPES,BIOLOGICALBUFFER
  • 1;4-PIPERAZINEDIETHANESULFONIC ACID;PIPERAZINE-N;N'-BIS(2-ETHANESULFONIC ACID);2;2'-(PIPERAZINE-1;4-DIYL)DIETHANESULFONIC ACID
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