Carnosic acid
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- CAS-Nr.
- 3650-09-7
- Englisch Name:
- Carnosic acid
- Synonyma:
- (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid;salvin;639426;carnosicaci;carosic acid;CARNOSIC ACID;CARNOSOLIC ACID;CARNOSIC ACID(P);CARNOSIC ACID(RG);Carnosic Acid >
- CBNumber:
- CB4367749
- Summenformel:
- C20H28O4
- Molgewicht:
- 332.43
- MOL-Datei:
- 3650-09-7.mol
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Carnosic acid Eigenschaften
- Schmelzpunkt:
- 190°C(lit.)
- Siedepunkt:
- 506.4±50.0 °C(Predicted)
- Dichte
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- powder
- pka
- 4.14±0.40(Predicted)
- Farbe
- yellow
- BRN
- 2707918
- InChIKey
- QRYRORQUOLYVBU-VBKZILBWSA-N
- LogP
- 5.405 (est)
- CAS Datenbank
- 3650-09-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
S-S?tze: |
22-24/25 |
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WGK Germany |
3 |
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HS Code |
29182900 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Carnosic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Yellow powder
Verwenden
Carnosic Acid is a phenolic component of rosemary. It acts as a potent antioxdant and also has UV protective activity. Specifically protection for UV-A radiation and damage. Carnosic Acid also inhibits the free-radical chain reaction that leads to the oxidation of fats and oils, thereby stabilizing and increasing the shelf life of meats.
Definition
ChEBI: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from Rosmarinus officinalis and exhibits anti-angiogenic, antineoplastic, antioxidant
and anti-HIV activity.
Anticancer Research
Carnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.
The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).
Carnosic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Carnosic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 367)Lieferanten
3650-09-7()Verwandte Suche:
- CARNOSOLIC ACID
- CARNOSIC ACID
- 4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-
- (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
- CARNOSIC ACID(P)
- CARNOSIC ACID(P)(NOW AVAILABLE IN GRAM SIZES)(P)
- salvin
- (4aR-trans)-1,3,4,9,10,10a-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4a(2H)-phenanthrenecarboxylic acid
- Carnosic acid from Rosmarinus officinalis
- CARNOSIC ACID(RG)
- Carnosic Acid, Free Acid, >99%
- Deoxypicrosalvinic acid
- 1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4aR(2H)-phenanthrenecarboxylic acid Carnosic acid
- Carnosic acid, >=95%
- Carnosic acid, 99%, from Rosmarinus officinalis L.
- Carnosic Acid (Synthetic)
- Soluble CARNOSIC ACID, Liposomal CARNOSIC ACID, CARNOSIC ACID NanoEmulsion, NanoActive CARNOSIC ACID, BETA- CARNOSIC ACID
- Carnosic acid, 99%, from Rosmarinus officinalis
- Carnosic acid 5-95%
- Carnosic Acid >
- carnosicaci
- hot selling Carnosic acid
- Carnosic acid USP/EP/BP
- (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid
- carnosic acid oil
- carosic acid
- Murine tail oxalic acid
- Rosemary Extract Carnosic Acid Powder
- Miltiorrhiza Extract Tanshinone
- CARNOSIC ACID(RG) 10mg
- CARNOSIC ACID(RG) 1g
- CARNOSIC ACID(RG) 250mg
- CARNOSIC ACID(RG) 25mg
- 639426
- Carnosic acid, 10 mM in DMSO
- 3650-09-7
- 3650-9-7
- 6537-80-8
- 360-09-7
- 9005-64-6
- 8604-14-8
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Plant extracts
- Miscellaneous Natural Products
- chemical reagent
- pharmaceutical intermediate
- phytochemical