Apamin
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- CAS-Nr.
- 24345-16-2
- Bezeichnung:
- Apamin
- Englisch Name:
- APAMIN
- Synonyma:
- APAMIN;apamine;APAMIN, BEE VENOM;Apamin, ≥97% (HPLC);APAMIN FROM BEE VENOM;CNCKAPETALCARRCQQH-NH2;APAMIN FROM HONEY BEE VENOM;Apamin (trifluoroacetate salt);M.W. 2027.34 C79H131N31O24S4;APAMIN (HONEY BEE, APIS MELIFERA)
- CBNumber:
- CB4342708
- Summenformel:
- C79H131N31O24S4
- Molgewicht:
- 2027.34
- MOL-Datei:
- 24345-16-2.mol
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Apamin Eigenschaften
- Siedepunkt:
- 847.17°C (rough estimate)
- Dichte
- 1.63
- Brechungsindex
- 1.5530 (estimate)
- storage temp.
- -20°C
- L?slichkeit
- 0.05 M acetic acid: 5 mg/mL, clear, colorless to faintly yellow
- Aggregatzustand
- White solid with dark tan
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble to 1 mg/ml in water
- Merck
- 13,732
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
22-24/25 |
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| RIDADR |
2811 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
CD6899900 |
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| F |
3-10 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| Toxizit?t |
LD50 i.v. in mice: 4 mg/kg (Habermann, Reiz); LD50 intracerebroventricularly in mice: 12 ng/animal (Labbé-Jullié) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P342+P311 |
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Apamin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Small, highly potent, highly basic polypeptide.
Verwenden
Apamin has been used:
- As a selective inhibitor of small conductance (SKCa) channels in HEK cells.
- To inhibit endothelium-derived relaxing factor (EDHF) mediated responses.
- To block small-conductance Ca2-activated K current (ISK) in electrophysiological studies in hyperstriatum ventrale, pars caudalis (HVc) neurons.
Definition
Occurs in the venom of the honey bee, Apis mellifera; molecular weight of 2027.38.
Allgemeine Beschreibung
Apamin is a bee venom component and is strongly basic in nature. It has 18 amino acid residues and two disulphide bonds.
Hazard
Central nervous system poison able to cross the blood–brain barrier; neurotoxic; poison.
Sicherheitsprofil
Poison by intravenous, parenteral,intracerebral, and intraperitoneal routes. When heated todecomposition it emits toxic fumes of SOx and NOx.
Enzyminhibitor
This bee venom octadecapeptide toxin (FW = 2027.34 g/mol; CAS 24345- 16-2; NCBI Reference Sequence: NP_001011612.1) potently blocks the small-conductance Ca 2+ -activated potassium ion (or SK) channels hSK1 as well as rSK2, with IC50 values of 3.3 nM and 83 pM. It shows greater effectiveness at the SK2 channel (IC50 = 0.06-0.4 nM) than SK1 (IC50 = 1- 12 nM). SK3 (IC50 = 1-13 nM), and SK4 (IC50 = 1 μM) channels, and is active against channels within neurons, vascular endothelium, bladder smooth muscle, and certain cancers. Apamin does not inhibit human cardiac Na + current, L-type Ca 2+ current or other major K+ currents. Structurally, apamin forms a stable structure, consisting of a C-terminal a- helix and two reverse turns, that is stabilized by two disulfide bonds connecting Cys-1 to Cys-11 and Cys-3 to Cys-15. A minor constituent of venom of the bee (Apis mellifera), apamin amounts to only 2-3% (w/w) of its dry venom. The smallest known neurotoxic polypeptide, apamin is derived by proteolytic processing of the 48-residue pre-pro-protein. The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3'-exon.
Apamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Apamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 150)Lieferanten
24345-16-2(Apamin)Verwandte Suche:
- APAMIN, BEE VENOM
- APAMIN (HONEY BEE, APIS MELIFERA)
- apamine
- APAMIN FROM BEE VENOM
- APAMIN FROM HONEY BEE VENOM
- M.W. 2027.34 C79H131N31O24S4
- L-Cys-L-Asn-L-Cys-L-Lys-L-Ala-L-Pro-L-Glu-L-Thr-L-Ala-L-Leu-L-Cys-L-Ala-L-Arg-L-Arg-L-Cys-L-Gln-L-Gln-L-His-NH2
- CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG- ARG-CYS-GLN-GLN-HIS-NH2(DISULFIDE BRIDGE:CYS1-CYS11, CYS3-CYS15)
- L-Cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide cyclic (1-11) (3-15)-bis(disulfide) = Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-leu-Cyc-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
- APAMIN (HONEYBEE, APIS MELLIFERA)
- H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15)
- H-+CYS-ASN-++CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-+CYS-ALA-ARG-ARG-++CYS-GLN-GLN- HIS-NH2
- H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2
- H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2 (DISULFIDE BRIDGE: 1-11, 3-15)
- CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2
- CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-CYS-GLN-GLN-HIS-NH2
- [CYS-ASN-(CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS]CYCL-ALA-ARG-ARG-CYS)CYCL-GLN-GLN-HIS-NH2
- CNCKAPETALCARRCQQH-NH2
- CNCKAPETALCARRCQQH-NH2 (DISULFIDE BRIDGE: 1-11,3-15)
- APAMIN
- Apamin, ≥97% (HPLC)
- Apamin (trifluoroacetate salt)
- Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem
- 24345-16-2
- C79H131N31O24S4
- BioChemical
- Amino Acids and Peptides
- Biochemicals and Reagents
- Cell Biology
- Cell Signaling and Neuroscience
- Monovalent Ion Channels
- Other Peptides
- Potassium Channel Modulators
- Peptides
- Ion Channels
- Voltage-gated Ion Channels
- Ion Channels
- BeeVoltage-gated Ion Channels
- Cell Signaling and Neuroscience
- Ion Channel Modulating Peptides
- Monovalent Ion Channels
- Potassium Channel Modulators
- Potassium Channel ModulatorsPeptides for Cell Biology
- Toxins and Venoms
- Potassium channel
- Peptide
