2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid
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- CAS-Nr.
- 14919-77-8
- Bezeichnung:
- 2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid
- Englisch Name:
- Benserazide hydrochloride
- Synonyma:
- BENSERAZIDE HCL;RO 4-4602;BENPARIZDE;31796-68-6;Ro 4-4602/001;NCGC00093698-03;SPECTRUM1500137;Benserazide hydrochlo;Benserazid hydrochloride;BENSERAZIDE HYDROCHLORIDE
- CBNumber:
- CB4229025
- Summenformel:
- C10H16ClN3O5
- Molgewicht:
- 293.7
- MOL-Datei:
- 14919-77-8.mol
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2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid Eigenschaften
- Schmelzpunkt:
- 146°C
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: 10 mg/mL
- Aggregatzustand
- solid
- Farbe
- White to Off-White
- PH
- pH(10g/L, 25℃) : 4.0～5.0
- Biologische Quelle
- synthetic
- Wasserl?slichkeit
- Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.
- Sensitive
- Light Sensitive
- maximale Wellenl?nge (λmax)
- 272nm(HCl aq.)(lit.)
- Merck
- 14,1050
- InChIKey
- ULFCBIUXQQYDEI-UHFFFAOYSA-N
- CAS Datenbank
- 14919-77-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
VT9632300 |
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| HS Code |
29280000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park
nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe
given alone.
Allgemeine Beschreibung
Benserazide is a peripheral decarboxylase inhibitor.
2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 445)Lieferanten
14919-77-8(2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid)Verwandte Suche:
- RO 4-4602
- BENSERAZIDE HYDROCHLORIDE
- DL-SERINE 2[(2,3,4-TRIHYDROXYPHENYL)-METHYL] HYDRAZIDE HYDROCHLORIDE
- DL-SERINE 2-[(2,3,4-TRIHYDROXYPHENYL)METHYL]HYDRAZIDE HCL
- 2'-(2,3,4-trihydroxybenzyl)-dl-serinohydrazide monohydrochloride
- 2-(2,3,4-trihydroxybenzyl)hydrazide,monohydrochloride,dl-serin
- dl-serine,2-((2,3,4-trihydroxyphenyl)methyl)hydrazide,monohydrochloride
- dl-serine2-(2,3,4-trihydroxybenzyl)hydrazinehydrochloride
- BENSERAZIDE HYDROCHLORIDE EP2000
- BENSERAZIDE HYDROCHLORIDE \ PERIPHERAL D
- Benserazide HCl (Serazide)
- Benserazide HCl (Ro 4-4602)
- dl-serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
- BENPARIZDE
- DL-Serine N2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
- N'-(DL-Seryl)-N''-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
- N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
- Ro 4-4602/001
- Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, monohydrochloride (8CI)
- Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, monohydrochloride
- 2-(2,3,4-TRIHYDROXYBENZYL)HYDRAZIDE
- Benserazide hydrochloride(Benserazide HCl)
- Benserazide hydrochloride (Serazide)
- 2-AMino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
- N'-(2,3,4-trihydroxybenzyl)-2-amino-3-hydroxypropanehydrazide, hydrochloride(1:1)
- (S)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
- 31796-68-6
- Benserazide hydrochlo
- Madopa (Hoffmann-LaRoche)
- NCGC00093698-03
- SPECTRUM1500137
- Benserazide hydrochioride
- 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanohydrazide hydrochloride
- (2RS)-2-Amino-3-hydroxy-2′-(2,3,4-trihydroxybenzyl)propanohydrazide hydrochloride
- Benserazide hydrochloride, 98%, peripherally acting DOPA decarboxylase inhibitor
- Benserazide Hydrochloride >
- Benserazide hydrochloride CRS
- Benserazide for peak identification CRS
- Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, hydrochloride (1:1)
- Benserazide hydrochloride USP/EP/BP
- Benserazide D3 HydrochlorideQ: What is
Benserazide D3 Hydrochloride Q: What is the CAS Number of
Benserazide D3 Hydrochloride Q: What is the storage condition of
Benserazide D3 Hydrochloride Q: What are the applications of
Benserazide D3 Hydrochloride
- Benserazide HydrochlorideQ: What is
Benserazide Hydrochloride Q: What is the CAS Number of
Benserazide Hydrochloride Q: What is the storage condition of
Benserazide Hydrochloride Q: What are the applications of
Benserazide Hydrochloride
- BENSERAZIDE HCL
- Benserazid hydrochloride
- Benserazide Hydrochloride, ≥ 97.0%
- 2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
- N'-(2,3,4-Trihydroxybenzyl)-(2S)-Benserazide-d3
- Benzhydrazine hydrochloride
- Benzyserazine hydrochloride
- 14919-77-8
- 14064-64-1
- 4919-77-8
- C10H16ClN3O5
- BioChemical
- Biochemicals and Reagents
- Aromatic amino acid decarboxylase, peripheral L-
- A to C
- Enzymes, Inhibitors, and Substrates
