1,2-Methylendioxybenzol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
R22:Gesundheitssch?dlich beim Verschlucken.
R10:Entzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.
Chemische Eigenschaften
clear colourless to light yellow liquid. Insoluble in acids.
Verwenden
1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.
Vorbereitung Methode
1,3-Benzodioxole is a colorless liquid. This compound is prepared by the reaction of catechol and dihalomethanes, for example, by use of concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.
Application
1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.
Definition
ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.
Allgemeine Beschreibung
Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.
1,2-Methylendioxybenzol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Chlor-1,3-benzodioxol
3,4-METHYLENEDIOXYPHENYL ISOTHIOCYANATE
3,4-(Methylendioxy)phenylacetonitril
1,2-(Methylendioxy)-4-nitrobenzol
Piperonal
4-Nitrobrenzcatechin
PIPERONYL FORMALDEHYDE
3-Ethoxy-4-hydroxybenzaldehyd
Benzo-1,3-dioxol-5-ethylamin
(+/-)-1-(1,3-Benzodioxol-5-yl)-2-broMo-1-pentanone
5-CHLORO-1,3-BENZODIOXOLE
N,N,N',N'-Tetraethylmethylendiamin
3,4-(METHYLENEDIOXY)BUTYROPHENONE
1,3-BENZODIOXOLE-4-CARBOXYLIC ACID
